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Gene · 9156

EXO1: exonuclease 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EXO1: exonuclease 1. Genes, record 9156. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9156

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Gene

Symbol
EXO1
HGNC
Name
exonuclease 1
HGNC
NCBI Gene ID
9156
NCBI Gene
HGNC ID
HGNC:3511
HGNC
Ensembl
ENSG00000174371
NCBI Gene
Aliases
HEX1, hExoI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UQ84Exonuclease 184625Ensembl, GeneID, HGNC

Source UniProt

Patents82

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12624353 B22026-05-123869Q9UQ84Espacenet
US 12624354 B22026-05-123869Q9UQ84Espacenet
JP 2026062659 A2026-04-103869Q9UQ84Espacenet
US 12570972 B22026-03-103869Q9UQ84Espacenet
US 12509680 B22025-12-303869Q9UQ84Espacenet
EP 4640849 A22025-10-29653Q9UQ84Espacenet
EP 4641201 A22025-10-294360Q9UQ84Espacenet
EP 4641202 A22025-10-294870Q9UQ84Espacenet
JP 2025100656 A2025-07-0318Q9UQ84Espacenet
WO 2025137408 A12025-06-26135Q9UQ84Espacenet

1 to 10 of 82

See all 82 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,219

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEXO1 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines612025
P30CA008748Cancer Center Support Grant272025
P30CA016672Cancer Center Support Grant212025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability212025
R01GM050006Enzymology of Mismatch Repair in Yeast182025
ZIAAG000752Model Genetic Systems to Study DNA Repair142025
ZIAAG000753Fanconi Anemia Pathway112025
R01ES007061Mechanisms of DNA Double-strand Break End Resection and Repair Pathway Choice102025
R01GM098535Molecular mechanisms of DNA damage signaling and repair102025
P30CA033572Cancer Center Support Grant92025

1 to 10 of 2,219Source NIH's project files

See all 2,219 nih grants

Papers3,400

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
BUB1 and CDK4/6 Dual Inhibition Increases Radiation Sensitivity in Glioblastoma, Lung Cancer, and Triple-Negative Breast Cancer.Biomedicines202642792682PubTator, text miningPubMed
A phenotype- and potency-gated extracellular vesicle allocation hypothesis for autism.Front Child Adolesc Psychiatry202642729530PubTator, text miningPubMed
Suppression of transcription-replication conflicts by sequence-coordinated actions of TRDMT1 and MutLα.Nat Commun202642706250PubTator, text miningPubMed
DNA damage response genes in lung cancer: Diagnostic, prognostic, and therapeutic implications - A narrative review.Crit Rev Oncol Hematol202642603641PubTator, text miningPubMed
Experimental Investigation of Nanolayered Silver and MXene Coatings for Enhanced Energy Efficiency in Compact Heat Exchangers.ACS Omega202642597894PubTator, text miningPubMed
Bacterial and gut microbiota-derived extracellular vesicles as emerging sources of cancer biomarkers: molecular mechanisms, diagnostic approaches, and therapeutic applications.Front Cell Infect Microbiol202642564071PubTator, text miningPubMed
CTCF primes repressive chromatin for rapid BRCA1/BARD1 recruitment to drive homologous recombination repair of DNA double-strand breaks.Nucleic Acids Res202642475683PubTator, text miningPubMed
All-in-one exome sequencing approach for genetic testing of unexplained premature ovarian insufficiency.Hum Reprod Open202642465592PubTator, text miningPubMed
Integrative systematic review and transcriptomic -machine learning analysis of molecular signatures in metaplastic breast cancer.Ecancermedicalscience202642416235PubTator, text miningPubMed
Molecular effects of ovarian stimulation for fertility preservation in breast cancer: a paired-biopsy analysis.ESMO Open202642413327PubTator, text miningPubMed

1 to 10 of 3,400

See all 3,400 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9156

GET https://conductscience.org/api/genes/v1/9156/patents?page=2