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CD3E: CD3 epsilon subunit of T-cell receptor complex

1 protein, 1,108 patents, 23 drugs, 580 trials, 5,210 NIH grants and 6,940 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCD3EHGNC
NameCD3 epsilon subunit of T-cell receptor complexHGNC
NCBI Gene ID916NCBI Gene
HGNC IDHGNC:1674HGNC
EnsemblENSG00000198851NCBI Gene
AliasesCD3-epsilon, CD3epsilon, IMD18, T3E, TCRENCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P07766T-cell surface glycoprotein CD3 epsilon chain20744Ensembl, GeneID, HGNCUniProt

Patents 1108

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026222432 A12026-10-2260P07766Espacenet
WO 2026222444 A12026-10-221P07766Espacenet
EP 4820057 A12026-10-14282P07766Espacenet
WO 2026193010 A22026-09-1719P07766Espacenet
EP 4778587 A22026-07-221P07766Espacenet
EP 4774292 A12026-07-15271P07766Espacenet
EP 4758171 A12026-06-1748P07766Espacenet
JP 2026090249 A2026-06-0223P07766Espacenet
JP 2026516673 A2026-05-262P07766Espacenet
JP 2026516046 A2026-05-197P07766Espacenet

Drugs 23

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BLINATUMOMABCHEMBL1742992T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
CATUMAXOMABCHEMBL2108581T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
ELRANATAMABCHEMBL4297809T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
EPCORITAMABCHEMBL4650393T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
ERTUMAXOMABCHEMBL2108029T-cell surface glycoprotein CD3 epsilon chain cross-linking agentCROSS-LINKING AGENTChEMBL
FBT-A05CHEMBL2109351T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
FLOTETUZUMABCHEMBL3990038T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
FORALUMABCHEMBL1743020T cell surface glycoprotein CD3 inhibitorINHIBITORChEMBL
GLOFITAMABCHEMBL4298092T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
HOKT3CHEMBL2109253T-cell surface glycoprotein CD3 epsilon chain inhibitorINHIBITORChEMBL

Trials 580

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416TECLISTAMABPHASE2ClinicalTrials.gov
NCT07598396MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07588698EPCORITAMABPHASE2ClinicalTrials.gov
NCT07581704TECLISTAMABPHASE1ClinicalTrials.gov
NCT07573670BLINATUMOMABPHASE2ClinicalTrials.gov
NCT07566364MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07564453BLINATUMOMABPHASE2ClinicalTrials.gov
NCT07555470MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07548450MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07531095TARLATAMABPHASE1ClinicalTrials.gov

NIH grants 5210

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant592,025NIH's project files
P30CA016672Cancer Center Support Grant432,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant152,025NIH's project files
P30CA016087Cancer Center Support Grant142,025NIH's project files
P30CA091842Cancer Center Support Grant142,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro142,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award142,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program132,025NIH's project files
P30CA016042Cancer Center Support Grant132,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)132,025NIH's project files

Papers 6940

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42774267PubTator, text miningPubMed
42754734PubTator, text miningPubMed
42738839PubTator, text miningPubMed
42696650PubTator, text miningPubMed
42669719PubTator, text miningPubMed
42635043PubTator, text miningPubMed
42621184PubTator, text miningPubMed
42619737PubTator, text miningPubMed
42531433PubTator, text miningPubMed
42529928PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license