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Gene · 91662

NLRP12: NLR family pyrin domain containing 12

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NLRP12: NLR family pyrin domain containing 12. Genes, record 91662. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/91662

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Gene

Symbol
NLRP12
HGNC
Name
NLR family pyrin domain containing 12
HGNC
NCBI Gene ID
91662
NCBI Gene
HGNC ID
HGNC:22938
HGNC
Ensembl
ENSG00000142405
NCBI Gene
Aliases
CLR19.3, FCAS2, Monarch1, NALP12, PAN6, PYPAF7, RNO, RNO2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P59046NACHT, LRR and PYD domains-containing protein 121,0613Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-294837P59046Espacenet
JP 2025517969 A2025-06-124837P59046Espacenet
JP 2024522216 A2024-06-11104P59046Espacenet
KR 1020240022540 A2024-02-20104P59046Espacenet
US 11564998 B22023-01-315464P59046Espacenet
US 11446398 B22022-09-2057239P59046Espacenet
JP 2022524081 A2022-04-27160210P59046Espacenet
US 10918740 B22021-02-169039P59046Espacenet
US 10869935 B22020-12-229039P59046Espacenet
US 10463751 B22019-11-055464P59046Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants910

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNLRP12 papersNewest fiscal year
P30CA016086Cancer Center Support Grant102025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation82025
R01AI124346Innate immune signaling and stress response62025
R01AI160179Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases52025
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer52025
T32AI007485Predoctoral Training Program in Immunology52025
P30ES005605Environmental Health Sciences Research Center42025
R01AI029564Molecular and Functional Analysis of Innate Immune Receptors42025
P30CA016672Cancer Center Support Grant32025
P30CA021765Cancer Center Support Grant (CCSG)32025

1 to 10 of 910Source NIH's project files

See all 910 nih grants

Papers1,632

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Identification of genetic variants associated with monogenic autoinflammatory diseases in patients with Still's disease using next-generation sequencing.Immunol Res202642821198PubTator, text miningPubMed
Beyond NLRP3: expanding the spectrum of NLR-associated autoinflammatory diseases.Rheumatology (Oxford)202642755046PubTator, text miningPubMed
Expression of the NLRP12/NF-κB/iNOS axis in lung tissues across stages of non-small cell lung cancer and its mechanism in mediating immune cell regulation.Transl Cancer Res202642724414PubTator, text miningPubMed
The role of PANoptosis in diabetes and its complications: mechanisms and therapeutic prospects.Front Immunol202642688959PubTator, text miningPubMed
Expression, Regulation and Therapeutic Implications of Nod-Like Receptors in Endodontics: A Narrative Review.Int Endod J202642677679PubTator, text miningPubMed
The NLRP12 Osteoimmune Checkpoint: Coordinating Inflammatory Signaling and Bone Remodeling.Biomedicines202642652098PubTator, text miningPubMed
Transcriptomic Markers of Immunosenescence in Cynomolgus Macaques: A Pilot Study.Genes (Basel)202642650137PubTator, text miningPubMed
NLRP12 in cancer: a context-dependent regulator of tumor progression, immunity, and metabolism.Front Oncol202642500290PubTator, text miningPubMed
PANoptosis and Immune Remodeling in the Tumor Microenvironment.FASEB J202642467537PubTator, text miningPubMed
Immune-stromal dysregulation and senescence in chronic spontaneous urticaria.J Allergy Clin Immunol Glob202642436760PubTator, text miningPubMed

1 to 10 of 1,632

See all 1,632 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/91662

GET https://conductscience.org/api/genes/v1/91662/patents?page=2