Gene · 91662
NLRP12: NLR family pyrin domain containing 12
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NLRP12: NLR family pyrin domain containing 12. Genes, record 91662. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/91662
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P59046 | NACHT, LRR and PYD domains-containing protein 12 | 1,061 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents25
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 4837 | P59046 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4837 | P59046 | Espacenet |
| JP 2024522216 A | 2024-06-11 | 104 | P59046 | Espacenet |
| KR 1020240022540 A | 2024-02-20 | 104 | P59046 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 5464 | P59046 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 57239 | P59046 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 160210 | P59046 | Espacenet |
| US 10918740 B2 | 2021-02-16 | 9039 | P59046 | Espacenet |
| US 10869935 B2 | 2020-12-22 | 9039 | P59046 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 5464 | P59046 | Espacenet |
1 to 10 of 25
See all 25 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants910
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NLRP12 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016086 | Cancer Center Support Grant | 10 | 2025 |
| R37AI101935 | Inflammatory Caspases in Innate Immunity and Inflammation | 8 | 2025 |
| R01AI124346 | Innate immune signaling and stress response | 6 | 2025 |
| R01AI160179 | Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases | 5 | 2025 |
| R35CA253095 | Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer | 5 | 2025 |
| T32AI007485 | Predoctoral Training Program in Immunology | 5 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 4 | 2025 |
| R01AI029564 | Molecular and Functional Analysis of Innate Immune Receptors | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
1 to 10 of 910Source NIH's project files
See all 910 nih grantsPapers1,632
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of genetic variants associated with monogenic autoinflammatory diseases in patients with Still's disease using next-generation sequencing. | Immunol Res | 2026 | 42821198 | PubTator, text mining | PubMed |
| Beyond NLRP3: expanding the spectrum of NLR-associated autoinflammatory diseases. | Rheumatology (Oxford) | 2026 | 42755046 | PubTator, text mining | PubMed |
| Expression of the NLRP12/NF-κB/iNOS axis in lung tissues across stages of non-small cell lung cancer and its mechanism in mediating immune cell regulation. | Transl Cancer Res | 2026 | 42724414 | PubTator, text mining | PubMed |
| The role of PANoptosis in diabetes and its complications: mechanisms and therapeutic prospects. | Front Immunol | 2026 | 42688959 | PubTator, text mining | PubMed |
| Expression, Regulation and Therapeutic Implications of Nod-Like Receptors in Endodontics: A Narrative Review. | Int Endod J | 2026 | 42677679 | PubTator, text mining | PubMed |
| The NLRP12 Osteoimmune Checkpoint: Coordinating Inflammatory Signaling and Bone Remodeling. | Biomedicines | 2026 | 42652098 | PubTator, text mining | PubMed |
| Transcriptomic Markers of Immunosenescence in Cynomolgus Macaques: A Pilot Study. | Genes (Basel) | 2026 | 42650137 | PubTator, text mining | PubMed |
| NLRP12 in cancer: a context-dependent regulator of tumor progression, immunity, and metabolism. | Front Oncol | 2026 | 42500290 | PubTator, text mining | PubMed |
| PANoptosis and Immune Remodeling in the Tumor Microenvironment. | FASEB J | 2026 | 42467537 | PubTator, text mining | PubMed |
| Immune-stromal dysregulation and senescence in chronic spontaneous urticaria. | J Allergy Clin Immunol Glob | 2026 | 42436760 | PubTator, text mining | PubMed |
1 to 10 of 1,632
See all 1,632 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/91662
GET https://conductscience.org/api/genes/v1/91662/patents?page=2