ConductScience.org, home

Gene · 917

CD3G: CD3 gamma subunit of T-cell receptor complex

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. CD3G: CD3 gamma subunit of T-cell receptor complex. Genes, record 917. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/917

On this page

Gene

Symbol
CD3G
HGNC
Name
CD3 gamma subunit of T-cell receptor complex
HGNC
NCBI Gene ID
917
NCBI Gene
HGNC ID
HGNC:1675
HGNC
Ensembl
ENSG00000160654
NCBI Gene
Aliases
CD3-GAMMA, CD3GAMMA, IMD17, T3G
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P09693T-cell surface glycoprotein CD3 gamma chain18238Ensembl, GeneID, HGNC

Source UniProt

Patents538

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026193010 A22026-09-1720P09693Espacenet
EP 4774292 A12026-07-15273P09693Espacenet
EP 4758171 A12026-06-1745P09693Espacenet
EP 4752227 A22026-06-0322P09693Espacenet
JP 2026516046 A2026-05-1921P09693Espacenet
JP 2026516052 A2026-05-1921P09693Espacenet
JP 2026054469 A2026-03-2638P09693Espacenet
EP 4704863 A22026-03-1121P09693Espacenet
EP 4705334 A12026-03-1121P09693Espacenet
EP 4694917 A12026-02-18562P09693Espacenet

1 to 10 of 538

See all 538 patents

Drugs16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BLINATUMOMABCHEMBL1742992T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
CATUMAXOMABCHEMBL2108581T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
ELRANATAMABCHEMBL4297809T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
EPCORITAMABCHEMBL4650393T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
FBT-A05CHEMBL2109351T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
FLOTETUZUMABCHEMBL3990038T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
FORALUMABCHEMBL1743020T cell surface glycoprotein CD3 inhibitorINHIBITORChEMBL
GLOFITAMABCHEMBL4298092T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
IMC-GP100CHEMBL2109434T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
MOSUNETUZUMABCHEMBL4297788T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL

1 to 10 of 16

See all 16 drugs

Trials532

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416TECLISTAMABPHASE2ClinicalTrials.gov
NCT07598396MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07588698EPCORITAMABPHASE2ClinicalTrials.gov
NCT07581704TECLISTAMABPHASE1ClinicalTrials.gov
NCT07573670BLINATUMOMABPHASE2ClinicalTrials.gov
NCT07566364MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07564453BLINATUMOMABPHASE2ClinicalTrials.gov
NCT07555470MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07548450MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07531095TARLATAMABPHASE1ClinicalTrials.gov

1 to 10 of 532

See all 532 trials

NIH grants1,403

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCD3G papersNewest fiscal year
P30CA008748Cancer Center Support Grant162025
P30CA016672Cancer Center Support Grant132025
P30CA014051Cancer Center Support (Core) Grant72025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies62025
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)62025
UL1TR001863Yale Clinical and Translational Science Award62025
R01CA155010Personal tumor neoantigens for immunity against chronic lymphocytic leukemia52025
T32HG002295Training in Bioinformatics and Integrative Genomics52025
UL1TR002345Washington University Institute of Clinical and Translational Sciences52025
K12CA090354Training Program in Nervous System Tumors42025

1 to 10 of 1,403Source NIH's project files

See all 1,403 nih grants

Papers1,874

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Expanding the clinical spectrum of CD3γ deficiency: comprehensive characterization of adult-onset disease and integrated reevaluation of all reported patients.Front Immunol202642661620PubTator, text miningPubMed
High-efficiency 14-plex cSNP SNaPshot assay for forensic peripheral blood identification.BMC Genomics202642436368PubTator, text miningPubMed
Decoding the human PBMC isonome: isoform-level resolution with single-cell long-read transcriptomics.Front Genet202642283034PubTator, text miningPubMed
Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells.Nat Immunol202642230957PubTator, text miningPubMed
Genetic Analysis of Patients With Common Variable Immunodeficiency Followed in the Pulmonology Department: A Report of Five Patients.Cureus202642220820PubTator, text miningPubMed
Exploration of CD2 and CD3D as potential immune-related biomarkers for IORT in breast cancer treatment.Medicine (Baltimore)202642065189PubTator, text miningPubMed
Integrated bioinformatics analysis of molecular signatures and therapeutic targets in early sepsis.Front Cell Infect Microbiol202641947789PubTator, text miningPubMed
A single-cell and spatial transcriptomic atlas of human tuberculous constrictive pericardium.EBioMedicine202641875497PubTator, text miningPubMed
Cytomegalovirus Drives the Development of Cytotoxic CD4+ T Cells in Patients With Multiple Sclerosis.Neurol Neuroimmunol Neuroinflamm202641871309PubTator, text miningPubMed
Human CD3 complex is required for the generation of T-cell receptor-like chimeric antigen receptor targeting WT1 in natural killer cells.Cancer Immunol Immunother202641843174PubTator, text miningPubMed

1 to 10 of 1,874

See all 1,874 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/917

GET https://conductscience.org/api/genes/v1/917/patents?page=2