Gene · 9173
IL33R: interleukin 33 receptor
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IL33R: interleukin 33 receptor. Genes, record 9173. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9173
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q01638 | Interleukin-1 receptor-like 1 | 556 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents120
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4795154 A1 | 2026-08-26 | 125 | Q01638 | Espacenet |
| EP 4757832 A1 | 2026-06-17 | 3 | Q01638 | Espacenet |
| US 12624114 B2 | 2026-05-12 | 352 | Q01638 | Espacenet |
| US 12612462 B2 | 2026-04-28 | 352 | Q01638 | Espacenet |
| JP 2026016421 A | 2026-02-03 | 352 | Q01638 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 50139 | Q01638 | Espacenet |
| JP 2025172069 A | 2025-11-20 | 226 | Q01638 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 871 | Q01638 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 613 | Q01638 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 6984 | Q01638 | Espacenet |
1 to 10 of 120
See all 120 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| ASTEGOLIMAB | CHEMBL4594385 | IL-33 receptor (ST2) inhibitor | INHIBITOR |
Source ChEMBL
Trials6
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05878769 | ASTEGOLIMAB | PHASE3 | ClinicalTrials.gov | |
| NCT05595642 | ASTEGOLIMAB | PHASE3 | ClinicalTrials.gov | |
| NCT05037929 | ASTEGOLIMAB | PHASE2 | ClinicalTrials.gov | |
| NCT03747575 | ASTEGOLIMAB | PHASE2 | 2023-05-06 | ClinicalTrials.gov |
| NCT03615040 | ASTEGOLIMAB | PHASE2 | 2022-05-24 | ClinicalTrials.gov |
| NCT02918019 | ASTEGOLIMAB | PHASE2 | 2022-12-28 | ClinicalTrials.gov |
NIH grants2,721
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IL33R papers | Newest fiscal year |
|---|---|---|---|
| U01AI095608 | Regulation of mucosal immunity by neuronal pathways | 12 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 11 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| U19AI070535 | Airway Inflammation and Airway Remodeling in Severe Asthma | 9 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 9 | 2025 |
| R01AI124355 | Genetic and Immunological Dissection of Eosinophilic Esophagitis | 8 | 2025 |
| U19AI070235 | Epithelial Genes in Allergic Inflammation | 8 | 2025 |
| T32HL007427 | SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES | 7 | 2025 |
| ZIAHD002400 | The Role Of Subclinical Infection And Cytokines In Preterm Parturition | 7 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 2,721Source NIH's project files
See all 2,721 nih grantsPapers3,690
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Multi-Ancestry Genome-wide Association Analyses Identify Shared and Specific Genetic Architecture in Mild and Moderate-to-Severe Asthma. | medRxiv | 2026 | 42818167 | PubTator, text mining | PubMed |
| Clinical and Proteomic Biomarkers of Trifluridine/Tipiracil in Fluoropyrimidine-Refractory Advanced Pancreatic Adenocarcinoma: A Single-Arm Phase II Trial. | JCO Precis Oncol | 2026 | 42777178 | PubTator, text mining | PubMed |
| Intracellular Ca2+ balances the anti-inflammatory potential of IL-33-activated mast cells (MCs). | Cell Calcium | 2026 | 42753352 | PubTator, text mining | PubMed |
| Genome-wide association study of asthma with high treatment burden and/or worse outcomes defined using electronic healthcare data in UK Biobank. | ERJ Open Res | 2026 | 42682922 | PubTator, text mining | PubMed |
| IL-33/IL1RL1 (ST2) signalling drives immune suppression in squamous intraepithelial hyperplasia. | Tumour Virus Res | 2026 | 42679897 | PubTator, text mining | PubMed |
| Structural and functional consequences of IL33 and IL1RL1 coding variants on IL-33/ST2 signaling. | Genes Immun | 2026 | 42552443 | PubTator, text mining | PubMed |
| Multimodal gene prioritization reveals nonlinear regulatory architecture in childhood-onset asthma. | medRxiv | 2026 | 42523538 | PubTator, text mining | PubMed |
| Mendelian Randomization Analysis of the IL-1 Cytokine Family Proteins Identifies IL1RL1 as a Potential Causal Contributor to Traumatic Brain Injury Prognosis. | Neurocrit Care | 2026 | 42521903 | PubTator, text mining | PubMed |
| Elevated IL1RL1 expression is correlated with the persistence of childhood allergies. | J Asthma | 2026 | 42427164 | PubTator, text mining | PubMed |
| AI-based prediction of aspirin-exacerbated respiratory disease using nasal epithelial mRNA expression profiles. | J Allergy Clin Immunol Glob | 2026 | 42405352 | PubTator, text mining | PubMed |
1 to 10 of 3,690
See all 3,690 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9173
GET https://conductscience.org/api/genes/v1/9173/patents?page=2