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Gene · 9173

IL33R: interleukin 33 receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL33R: interleukin 33 receptor. Genes, record 9173. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9173

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Gene

Symbol
IL33R
HGNC
Name
interleukin 33 receptor
HGNC
NCBI Gene ID
9173
NCBI Gene
HGNC ID
HGNC:5998
HGNC
Ensembl
ENSG00000115602
NCBI Gene
Aliases
DER4, FIT-1, IL-33R, IL1RL1, ST2, ST2L, ST2V, T1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q01638Interleukin-1 receptor-like 15561Ensembl, GeneID, HGNC

Source UniProt

Patents120

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4795154 A12026-08-26125Q01638Espacenet
EP 4757832 A12026-06-173Q01638Espacenet
US 12624114 B22026-05-12352Q01638Espacenet
US 12612462 B22026-04-28352Q01638Espacenet
JP 2026016421 A2026-02-03352Q01638Espacenet
JP 2026004568 A2026-01-1450139Q01638Espacenet
JP 2025172069 A2025-11-20226Q01638Espacenet
EP 4650780 A22025-11-19871Q01638Espacenet
EP 4641201 A22025-10-29613Q01638Espacenet
JP 2025147176 A2025-10-066984Q01638Espacenet

1 to 10 of 120

See all 120 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ASTEGOLIMABCHEMBL4594385IL-33 receptor (ST2) inhibitorINHIBITOR

Source ChEMBL

Trials6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05878769ASTEGOLIMABPHASE3ClinicalTrials.gov
NCT05595642ASTEGOLIMABPHASE3ClinicalTrials.gov
NCT05037929ASTEGOLIMABPHASE2ClinicalTrials.gov
NCT03747575ASTEGOLIMABPHASE22023-05-06ClinicalTrials.gov
NCT03615040ASTEGOLIMABPHASE22022-05-24ClinicalTrials.gov
NCT02918019ASTEGOLIMABPHASE22022-12-28ClinicalTrials.gov

NIH grants2,721

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL33R papersNewest fiscal year
U01AI095608Regulation of mucosal immunity by neuronal pathways122025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease112025
P30CA008748Cancer Center Support Grant92025
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma92025
UL1TR001863Yale Clinical and Translational Science Award92025
R01AI124355Genetic and Immunological Dissection of Eosinophilic Esophagitis82025
U19AI070235Epithelial Genes in Allergic Inflammation82025
T32HL007427SYSTEMS APPROACHES TO THE EPIDEMIOLOGY, GENETICS AND GENOMICS OF LUNG DISEASES72025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition72025
P30CA068485Cancer Center Support Grant62025

1 to 10 of 2,721Source NIH's project files

See all 2,721 nih grants

Papers3,690

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-Ancestry Genome-wide Association Analyses Identify Shared and Specific Genetic Architecture in Mild and Moderate-to-Severe Asthma.medRxiv202642818167PubTator, text miningPubMed
Clinical and Proteomic Biomarkers of Trifluridine/Tipiracil in Fluoropyrimidine-Refractory Advanced Pancreatic Adenocarcinoma: A Single-Arm Phase II Trial.JCO Precis Oncol202642777178PubTator, text miningPubMed
Intracellular Ca2+ balances the anti-inflammatory potential of IL-33-activated mast cells (MCs).Cell Calcium202642753352PubTator, text miningPubMed
Genome-wide association study of asthma with high treatment burden and/or worse outcomes defined using electronic healthcare data in UK Biobank.ERJ Open Res202642682922PubTator, text miningPubMed
IL-33/IL1RL1 (ST2) signalling drives immune suppression in squamous intraepithelial hyperplasia.Tumour Virus Res202642679897PubTator, text miningPubMed
Structural and functional consequences of IL33 and IL1RL1 coding variants on IL-33/ST2 signaling.Genes Immun202642552443PubTator, text miningPubMed
Multimodal gene prioritization reveals nonlinear regulatory architecture in childhood-onset asthma.medRxiv202642523538PubTator, text miningPubMed
Mendelian Randomization Analysis of the IL-1 Cytokine Family Proteins Identifies IL1RL1 as a Potential Causal Contributor to Traumatic Brain Injury Prognosis.Neurocrit Care202642521903PubTator, text miningPubMed
Elevated IL1RL1 expression is correlated with the persistence of childhood allergies.J Asthma202642427164PubTator, text miningPubMed
AI-based prediction of aspirin-exacerbated respiratory disease using nasal epithelial mRNA expression profiles.J Allergy Clin Immunol Glob202642405352PubTator, text miningPubMed

1 to 10 of 3,690

See all 3,690 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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