Gene · 9177
HTR3B: 5-hydroxytryptamine receptor 3B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HTR3B: 5-hydroxytryptamine receptor 3B. Genes, record 9177. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9177
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95264 | 5-hydroxytryptamine receptor 3B | 441 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents39
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026082870 A | 2026-05-19 | 57 | O95264 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 35774 | O95264 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1785 | O95264 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2009 | O95264 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2009 | O95264 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1785 | O95264 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 408 | O95264 | Espacenet |
| JP 2025508427 A | 2025-03-26 | 57 | O95264 | Espacenet |
| JP 2025508429 A | 2025-03-26 | 57 | O95264 | Espacenet |
| JP 2025004243 A | 2025-01-14 | 57 | O95264 | Espacenet |
1 to 10 of 39
See all 39 patentsDrugs16
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| AMISULPRIDE | CHEMBL243712 | Serotonin (5-HT) receptor antagonist | ANTAGONIST | ChEMBL |
| CILANSETRON | CHEMBL2103778 | Serotonin 3 (5-HT3) receptor antagonist | ANTAGONIST | ChEMBL |
| CLOTHIAPINE | CHEMBL304902 | Serotonin 3 (5-HT3) receptor antagonist | ANTAGONIST | ChEMBL |
| DEXFENFLURAMINE | CHEMBL248702 | Serotonin (5-HT) receptor agonist | AGONIST | ChEMBL |
| DEXFENFLURAMINE HYDROCHLORIDE | CHEMBL1887891 | Serotonin (5-HT) receptor agonist | AGONIST | ChEMBL |
| FACINICLINE | CHEMBL2151439 | Serotonin 3 (5-HT3) receptor antagonist | ANTAGONIST | ChEMBL |
| FACINICLINE HYDROCHLORIDE | CHEMBL5095032 | Serotonin 3 (5-HT3) receptor antagonist | ANTAGONIST | ChEMBL |
| MOSAPRIDE | CHEMBL60889 | Serotonin 3 (5-HT3) receptor antagonist | ANTAGONIST | ChEMBL |
| PUMOSETRAG | CHEMBL1643880 | Serotonin 3 (5-HT3) receptor partial agonist | PARTIAL AGONIST | ChEMBL |
| RAMOSETRON | CHEMBL1643895 | Serotonin 3 (5-HT3) receptor antagonist | ANTAGONIST | ChEMBL |
1 to 10 of 16
See all 16 drugsTrials67
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07152184 | AMISULPRIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06887621 | AMISULPRIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06585540 | AMISULPRIDE | PHASE3 | ClinicalTrials.gov | |
| NCT06581302 | AMISULPRIDE | ClinicalTrials.gov | ||
| NCT06166615 | RAMOSETRON | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT06040944 | AMISULPRIDE | ClinicalTrials.gov | ||
| NCT05956600 | AMISULPRIDE | ClinicalTrials.gov | ||
| NCT05347199 | AMISULPRIDE | PHASE1 | ClinicalTrials.gov | |
| NCT04954365 | AMISULPRIDE | ClinicalTrials.gov | ||
| NCT04533724 | AMISULPRIDE | EARLY_PHASE1 | ClinicalTrials.gov |
1 to 10 of 67
See all 67 trialsNIH grants381
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HTR3B papers | Newest fiscal year |
|---|---|---|---|
| ZIAAA000301 | Integrative genetics of behavior with high throughput technologies | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 2 | 2025 |
| P50AA012870 | Center for the Translational Neuroscience of Alcoholism | 2 | 2025 |
| P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 2 | 2025 |
| R01NS077114 | Probing the structure and function of the intracellular domain of cys-loop receptors | 2 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 2 | 2025 |
| UG1CA189974 | SWOG NCORP Research Base | 2 | 2025 |
| ZIAAA000407 | Synaptic Transmission: Modulation, Plasticity And Effects Of Drugs Of Abuse | 2 | 2025 |
| K12DA000167 | Clinician Scientist Training Program (CSTP) | 1 | 2025 |
1 to 10 of 381Source NIH's project files
See all 381 nih grantsPapers480
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Role of genetic polymorphisms on opioid safety and efficacy in cancer pain: A systematic review and meta-analysis. | Eur J Pharmacol | 2026 | 42492880 | PubTator, text mining | PubMed |
| Burden of rare genetic variants in genes associated with cancer among Malawian cervical cancer patients. | Afr J Lab Med | 2026 | 42266196 | PubTator, text mining | PubMed |
| Differential Expression of Endocannabinoid Receptors in Lesional and Non-Lesional Skin of Psoriasis Patients: Insights Into Pathogenesis and Potential Therapeutic Targets. | J Cutan Med Surg | 2026 | 41699832 | PubTator, text mining | PubMed |
| Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease. | Mov Disord | 2026 | 41618568 | PubTator, text mining | PubMed |
| Detecting suicide risk in bipolar disorder patients from lymphoblastoid cell lines genetic signatures. | Transl Psychiatry | 2025 | 40903457 | PubTator, text mining | PubMed |
| Personalized Prophylactic Antiemetic Regimens for Control of Chemotherapy-Induced Nausea and Vomiting by Pharmacogenetic Analysis of Three Receptor Genes: HTR3A, HTR3B, TACR1. | JCO Precis Oncol | 2025 | 40249884 | PubTator, text mining | PubMed |
| Association between 5-HTRs gene polymorphism and alcohol use disorder in Han males from Yunnan, China. | Alcohol | 2025 | 39889837 | PubTator, text mining | PubMed |
| Serotonin Receptors Polymorphisms Are Associated With Cyclic Vomiting Syndrome. | Neurogastroenterol Motil | 2025 | 39888244 | PubTator, text mining | PubMed |
| Identification of ion channel-related genes as diagnostic markers and potential therapeutic targets for osteoarthritis through bioinformatics and machine learning-based approaches. | Biomarkers | 2024 | 38767974 | PubTator, text mining | PubMed |
| Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample. | Sci Rep | 2024 | 38493193 | PubTator, text mining | PubMed |
1 to 10 of 480
See all 480 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9177
GET https://conductscience.org/api/genes/v1/9177/patents?page=2