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Gene · 9177

HTR3B: 5-hydroxytryptamine receptor 3B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HTR3B: 5-hydroxytryptamine receptor 3B. Genes, record 9177. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9177

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Gene

Symbol
HTR3B
HGNC
Name
5-hydroxytryptamine receptor 3B
HGNC
NCBI Gene ID
9177
NCBI Gene
HGNC ID
HGNC:5298
HGNC
Ensembl
ENSG00000149305
NCBI Gene
Aliases
5-HT3B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O952645-hydroxytryptamine receptor 3B4410Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082870 A2026-05-1957O95264Espacenet
JP 2026004568 A2026-01-1435774O95264Espacenet
EP 4650780 A22025-11-191785O95264Espacenet
JP 2025529142 A2025-09-042009O95264Espacenet
US 12371689 B22025-07-292009O95264Espacenet
JP 2025517970 A2025-06-121785O95264Espacenet
JP 2025062604 A2025-04-14408O95264Espacenet
JP 2025508427 A2025-03-2657O95264Espacenet
JP 2025508429 A2025-03-2657O95264Espacenet
JP 2025004243 A2025-01-1457O95264Espacenet

1 to 10 of 39

See all 39 patents

Drugs16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMISULPRIDECHEMBL243712Serotonin (5-HT) receptor antagonistANTAGONISTChEMBL
CILANSETRONCHEMBL2103778Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
CLOTHIAPINECHEMBL304902Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
DEXFENFLURAMINECHEMBL248702Serotonin (5-HT) receptor agonistAGONISTChEMBL
DEXFENFLURAMINE HYDROCHLORIDECHEMBL1887891Serotonin (5-HT) receptor agonistAGONISTChEMBL
FACINICLINECHEMBL2151439Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
FACINICLINE HYDROCHLORIDECHEMBL5095032Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
MOSAPRIDECHEMBL60889Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL
PUMOSETRAGCHEMBL1643880Serotonin 3 (5-HT3) receptor partial agonistPARTIAL AGONISTChEMBL
RAMOSETRONCHEMBL1643895Serotonin 3 (5-HT3) receptor antagonistANTAGONISTChEMBL

1 to 10 of 16

See all 16 drugs

Trials67

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07152184AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06887621AMISULPRIDEPHASE2ClinicalTrials.gov
NCT06585540AMISULPRIDEPHASE3ClinicalTrials.gov
NCT06581302AMISULPRIDEClinicalTrials.gov
NCT06166615RAMOSETRONPHASE2/PHASE3ClinicalTrials.gov
NCT06040944AMISULPRIDEClinicalTrials.gov
NCT05956600AMISULPRIDEClinicalTrials.gov
NCT05347199AMISULPRIDEPHASE1ClinicalTrials.gov
NCT04954365AMISULPRIDEClinicalTrials.gov
NCT04533724AMISULPRIDEEARLY_PHASE1ClinicalTrials.gov

1 to 10 of 67

See all 67 trials

NIH grants381

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHTR3B papersNewest fiscal year
ZIAAA000301Integrative genetics of behavior with high throughput technologies72025
P30CA016672Cancer Center Support Grant32025
P30CA076292Moffitt Cancer Center Support Grant22025
P50AA012870Center for the Translational Neuroscience of Alcoholism22025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology22025
R01NS077114Probing the structure and function of the intracellular domain of cys-loop receptors22025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).22025
UG1CA189974SWOG NCORP Research Base22025
ZIAAA000407Synaptic Transmission: Modulation, Plasticity And Effects Of Drugs Of Abuse22025
K12DA000167Clinician Scientist Training Program (CSTP)12025

1 to 10 of 381Source NIH's project files

See all 381 nih grants

Papers480

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Role of genetic polymorphisms on opioid safety and efficacy in cancer pain: A systematic review and meta-analysis.Eur J Pharmacol202642492880PubTator, text miningPubMed
Burden of rare genetic variants in genes associated with cancer among Malawian cervical cancer patients.Afr J Lab Med202642266196PubTator, text miningPubMed
Differential Expression of Endocannabinoid Receptors in Lesional and Non-Lesional Skin of Psoriasis Patients: Insights Into Pathogenesis and Potential Therapeutic Targets.J Cutan Med Surg202641699832PubTator, text miningPubMed
Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease.Mov Disord202641618568PubTator, text miningPubMed
Detecting suicide risk in bipolar disorder patients from lymphoblastoid cell lines genetic signatures.Transl Psychiatry202540903457PubTator, text miningPubMed
Personalized Prophylactic Antiemetic Regimens for Control of Chemotherapy-Induced Nausea and Vomiting by Pharmacogenetic Analysis of Three Receptor Genes: HTR3A, HTR3B, TACR1.JCO Precis Oncol202540249884PubTator, text miningPubMed
Association between 5-HTRs gene polymorphism and alcohol use disorder in Han males from Yunnan, China.Alcohol202539889837PubTator, text miningPubMed
Serotonin Receptors Polymorphisms Are Associated With Cyclic Vomiting Syndrome.Neurogastroenterol Motil202539888244PubTator, text miningPubMed
Identification of ion channel-related genes as diagnostic markers and potential therapeutic targets for osteoarthritis through bioinformatics and machine learning-based approaches.Biomarkers202438767974PubTator, text miningPubMed
Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample.Sci Rep202438493193PubTator, text miningPubMed

1 to 10 of 480

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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