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Gene · 91807

MYLK3: myosin light chain kinase 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MYLK3: myosin light chain kinase 3. Genes, record 91807. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/91807

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Gene

Symbol
MYLK3
HGNC
Name
myosin light chain kinase 3
HGNC
NCBI Gene ID
91807
NCBI Gene
HGNC ID
HGNC:29826
HGNC
Ensembl
ENSG00000140795
NCBI Gene
Aliases
MLCK, MLCK2, caMLCK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q32MK0Myosin light chain kinase 38190Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454622Q32MK0Espacenet
EP 4641201 A22025-10-2911658Q32MK0Espacenet
JP 2025529142 A2025-09-042764Q32MK0Espacenet
US 12371689 B22025-07-292764Q32MK0Espacenet
JP 2025517969 A2025-06-1211658Q32MK0Espacenet
JP 2023123507 A2023-09-0556Q32MK0Espacenet
JP 2023123507 A2023-09-0557Q32MK0Espacenet
US 11446398 B22022-09-2054358Q32MK0Espacenet
JP 2022524081 A2022-04-27157329Q32MK0Espacenet
US 11078247 B22021-08-037177Q32MK0Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,188

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMYLK3 papersNewest fiscal year
R01DK061931Mechanisms and pathophysiologic impact of claudin-2 modulation172025
R01DK068271Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.152025
P30CA014599Cancer Center Support Grant72025
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)62025
P30DK034854Integrated Epithelial and Muscosal Biology52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025
P01HL126609Cytoskeletal Regulation of Lung Endothelial Pathobiology in ARDS32025
P30CA008748Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30EY005722Center Core Grant for Vision Research32025

1 to 10 of 1,188Source NIH's project files

See all 1,188 nih grants

Papers1,557

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mechanisms related to increased susceptibility of the elderly lung to ventilator-induced lung injury: A scoping review.Exp Gerontol202642735803PubTator, text miningPubMed
An Updated Evidence Assessment of the Genetic Causes of Dilated Cardiomyopathy.Circulation202642708185PubTator, text miningPubMed
Osimertinib-Associated Cardiotoxicity in EGFR-Mutant Non-Small Cell Lung Cancer: Mechanisms, Phenotypes, and Surveillance.Cardiol Rev202642636333PubTator, text miningPubMed
Dysregulated bile acid metabolism impairs intestinal barrier integrity via defective GPBAR1 signaling in low-birth-weight suckling piglet.Anim Nutr202642602664PubTator, text miningPubMed
GPR56 regulates the expression of key androgen-target genes via G13-Rho-PKN1 axis and is overexpressed in prostate cancer.J Steroid Biochem Mol Biol202642498205PubTator, text miningPubMed
Coronary Artery Vasospasm: Cellular and Molecular Insights.Cells202642439622PubTator, text miningPubMed
Tamoxifen Modulates Actin Stress Fibre Dynamics Through c-Src-MLCK Signalling in Breast Cancer Cells.Cell Biol Int202642187620PubTator, text miningPubMed
Xylooligosaccharides ameliorate intestinal barrier injury by inhibiting apoptosis, RhoA/ROCK/MLCK signaling and NKG2DLs in intestinal epithelial cells.Food Res Int202642116516PubTator, text miningPubMed
Thrombin-mediated increased permeability of blood-brain barrier in diquat poisoning: Mechanistic insights and potential therapeutic targets.Ecotoxicol Environ Saf202641926806PubTator, text miningPubMed
Chaperonin in health and disease.Mol Biomed202641920440PubTator, text miningPubMed

1 to 10 of 1,557

See all 1,557 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/91807

GET https://conductscience.org/api/genes/v1/91807/patents?page=2