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Gene · 9184

BUB3: BUB3 mitotic checkpoint protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BUB3: BUB3 mitotic checkpoint protein. Genes, record 9184. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9184

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Gene

Symbol
BUB3
HGNC
Name
BUB3 mitotic checkpoint protein
HGNC
NCBI Gene ID
9184
NCBI Gene
HGNC ID
HGNC:1151
HGNC
Ensembl
ENSG00000154473
NCBI Gene
Aliases
BUB3L, hBUB3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43684Mitotic checkpoint protein BUB33280Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439299O43684Espacenet
EP 4650780 A22025-11-198518O43684Espacenet
JP 2025517970 A2025-06-128518O43684Espacenet
JP 2025062604 A2025-04-1410049O43684Espacenet
US 11446398 B22022-09-2010049O43684Espacenet
JP 2022524081 A2022-04-27113020O43684Espacenet
JP 2021018154 A2021-02-15996O43684Espacenet
JP 2019054813 A2019-04-11219734O43684Espacenet
JP 2017121241 A2017-07-13219734O43684Espacenet
JP 2015516143 A2015-06-08219734O43684Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants880

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBUB3 papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase122025
P30CA021765Cancer Center Support Grant (CCSG)112025
P30CA016672Cancer Center Support Grant102025
P30CA023108Cancer Center Support Grant62025
P30CA008748Cancer Center Support Grant52025
R35GM128855Spindle Assembly Checkpoint Silencing52025
P30CA015704Cancer Center Support Grant42025
P50CA127001SPORE in Brain Cancer42025
R01GM074215Kinetochore Specification and Function42025
R01GM105755Timing and regulation of meiotic commitment42025

1 to 10 of 880Source NIH's project files

See all 880 nih grants

Papers1,385

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
RNA-binding protein RALYL-mediated BCL11B RNA stability promotes immune escape in small cell lung cancer through transcriptional activation of BUB3.Cell Oncol (Dordr)202642455237PubTator, text miningPubMed
hSpindly dynamics modulate spindle assembly checkpoint signaling, promoting resistance to mitotic inhibitors.iScience202642338480PubTator, text miningPubMed
NUF2 interacts with BUB3 and drives lung adenocarcinoma progression through activation of the NF-κB pathway.World J Surg Oncol202641943078PubTator, text miningPubMed
Mitotic error correction and the spindle assembly checkpoint: a tension-filled relationship.Cell Cycle202641930946PubTator, text miningPubMed
USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review).Int J Mol Med202641891958PubTator, text miningPubMed
Deubiquitinase USP8 regulates the spindle assembly checkpoint in oocytes.Sci Adv202641824582PubTator, text miningPubMed
Alterations in AR-FOXA1 signaling in prostate cancer progression and therapeutic resistance.J Natl Cancer Cent202641738032PubTator, text miningPubMed
Aneuploidy of chromosome 8 promotes the mesenchymal lineage during cell fate transitions.Sci Adv202641706839PubTator, text miningPubMed
Tumor cell cycle regulation: integrated perspective of stage characteristics, regulatory networks, and signaling pathway intervention strategies.Mol Biomed202641692895PubTator, text miningPubMed
The role of HMGA1 in genome stability: Implications in human cancer.Cell Mol Life Sci202641586900PubTator, text miningPubMed

1 to 10 of 1,385

See all 1,385 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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