Gene · 9184
BUB3: BUB3 mitotic checkpoint protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. BUB3: BUB3 mitotic checkpoint protein. Genes, record 9184. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9184
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43684 | Mitotic checkpoint protein BUB3 | 328 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 39299 | O43684 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8518 | O43684 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8518 | O43684 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10049 | O43684 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 10049 | O43684 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 113020 | O43684 | Espacenet |
| JP 2021018154 A | 2021-02-15 | 996 | O43684 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 219734 | O43684 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 219734 | O43684 | Espacenet |
| JP 2015516143 A | 2015-06-08 | 219734 | O43684 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants880
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | BUB3 papers | Newest fiscal year |
|---|---|---|---|
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 12 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| R35GM128855 | Spindle Assembly Checkpoint Silencing | 5 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 4 | 2025 |
| P50CA127001 | SPORE in Brain Cancer | 4 | 2025 |
| R01GM074215 | Kinetochore Specification and Function | 4 | 2025 |
| R01GM105755 | Timing and regulation of meiotic commitment | 4 | 2025 |
1 to 10 of 880Source NIH's project files
See all 880 nih grantsPapers1,385
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| RNA-binding protein RALYL-mediated BCL11B RNA stability promotes immune escape in small cell lung cancer through transcriptional activation of BUB3. | Cell Oncol (Dordr) | 2026 | 42455237 | PubTator, text mining | PubMed |
| hSpindly dynamics modulate spindle assembly checkpoint signaling, promoting resistance to mitotic inhibitors. | iScience | 2026 | 42338480 | PubTator, text mining | PubMed |
| NUF2 interacts with BUB3 and drives lung adenocarcinoma progression through activation of the NF-κB pathway. | World J Surg Oncol | 2026 | 41943078 | PubTator, text mining | PubMed |
| Mitotic error correction and the spindle assembly checkpoint: a tension-filled relationship. | Cell Cycle | 2026 | 41930946 | PubTator, text mining | PubMed |
| USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review). | Int J Mol Med | 2026 | 41891958 | PubTator, text mining | PubMed |
| Deubiquitinase USP8 regulates the spindle assembly checkpoint in oocytes. | Sci Adv | 2026 | 41824582 | PubTator, text mining | PubMed |
| Alterations in AR-FOXA1 signaling in prostate cancer progression and therapeutic resistance. | J Natl Cancer Cent | 2026 | 41738032 | PubTator, text mining | PubMed |
| Aneuploidy of chromosome 8 promotes the mesenchymal lineage during cell fate transitions. | Sci Adv | 2026 | 41706839 | PubTator, text mining | PubMed |
| Tumor cell cycle regulation: integrated perspective of stage characteristics, regulatory networks, and signaling pathway intervention strategies. | Mol Biomed | 2026 | 41692895 | PubTator, text mining | PubMed |
| The role of HMGA1 in genome stability: Implications in human cancer. | Cell Mol Life Sci | 2026 | 41586900 | PubTator, text mining | PubMed |
1 to 10 of 1,385
See all 1,385 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9184
GET https://conductscience.org/api/genes/v1/9184/patents?page=2