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Gene · 9188

DDX21: DExD-box helicase 21

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DDX21: DExD-box helicase 21. Genes, record 9188. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9188

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Gene

Symbol
DDX21
HGNC
Name
DExD-box helicase 21
HGNC
NCBI Gene ID
9188
NCBI Gene
HGNC ID
HGNC:2744
HGNC
Ensembl
ENSG00000165732
NCBI Gene
Aliases
GUA, GURDB, Gu-alpha, II/Gu, RH, RH II/Gu, RH-II/GU, RH-II/GuA, gu-alpha
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NR30Nucleolar RNA helicase 27835Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443130Q9NR30Espacenet
EP 4650780 A22025-11-197034Q9NR30Espacenet
EP 4641201 A22025-10-296915Q9NR30Espacenet
EP 4641202 A22025-10-295216Q9NR30Espacenet
JP 2025517969 A2025-06-126915Q9NR30Espacenet
JP 2025517970 A2025-06-127034Q9NR30Espacenet
KR 1020250017231 A2025-02-045216Q9NR30Espacenet
US 11446398 B22022-09-2022722Q9NR30Espacenet
JP 2022524081 A2022-04-27125693Q9NR30Espacenet
US 11078247 B22021-08-032960Q9NR30Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,004

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDDX21 papersNewest fiscal year
P30CA008748Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant72025
R01DK069710The Role of Nuclear PARPs in Signal-Regulated Transcription62025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center52025
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens32025
P01CA092584Structural Cell Biology of DNA Repair Machines32025
P30CA036727Buffett Cancer Center Support Grant32025
P30CA091842Cancer Center Support Grant32025
P30ES019776HERCULES: Exposome Research Center32025
T32AI060537Integrative Microbiology Program32025

1 to 10 of 1,004Source NIH's project files

See all 1,004 nih grants

Papers1,289

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genome-Wide CRISPR Screens Identify Genome Stability as Regulator of the Cellular Sensitivity to Environmentally Relevant Bisphenol A Exposure.Biomolecules202642793135PubTator, text miningPubMed
DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2-Mediated DNA Damage Response.Adv Sci (Weinh)202642750169PubTator, text miningPubMed
An ATP-Driven N Protein-DDX21 Molecular Switch Dynamically Controls SARS-CoV-2 RNA G-Quadruplex Heterogeneity.Adv Sci (Weinh)202642750138PubTator, text miningPubMed
KPNA1/importin α5 localizes to the nucleolus and associates with box C/D snoRNP complexes.Biochem Biophys Res Commun202642659866PubTator, text miningPubMed
Plakophilin 1 suppresses keratinocyte innate immune responses through DExD/H helicases.Cell Mol Immunol202642618693PubTator, text miningPubMed
R-loops in colorectal cancer: mechanisms, mapping strategies, and therapeutic opportunities.Mol Biol Rep202642593691PubTator, text miningPubMed
Histone Lactylation Mediated by circRNA-Facilitated FXR1 Phase Separation Promotes Colorectal Cancer Progression.Cancer Res202642554628PubTator, text miningPubMed
Human RPL7 and DDX21 function synergistically with HTLV-1 Gag to overcome genomic RNA structural barriers that block tRNAPro primer annealing.Nucleic Acids Res202642444604PubTator, text miningPubMed
The complete mitochondrial genome of the Boulenophrys xianjuensis (Anura: Megophryidae).Mitochondrial DNA B Resour202642370214PubTator, text miningPubMed
DDX21 Promotes Breast Cancer Growth and Metastasis via Stimulating RNAPII Elongation During Hypoxia.MedComm (2020)202642311859PubTator, text miningPubMed

1 to 10 of 1,289

See all 1,289 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9188

GET https://conductscience.org/api/genes/v1/9188/patents