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Gene · 91937

TIMD4: T cell immunoglobulin and mucin domain containing 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TIMD4: T cell immunoglobulin and mucin domain containing 4. Genes, record 91937. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/91937

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Gene

Symbol
TIMD4
HGNC
Name
T cell immunoglobulin and mucin domain containing 4
HGNC
NCBI Gene ID
91937
NCBI Gene
HGNC ID
HGNC:25132
HGNC
Ensembl
ENSG00000145850
NCBI Gene
Aliases
SMUCKLER, TIM4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96H15T-cell immunoglobulin and mucin domain-containing protein 43783Ensembl, GeneID, HGNC

Source UniProt

Patents64

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4759327 A22026-06-171Q96H15Espacenet
US 12648964 B22026-06-091Q96H15Espacenet
EP 4650780 A22025-11-192912Q96H15Espacenet
EP 4640849 A22025-10-29359Q96H15Espacenet
EP 4641201 A22025-10-292473Q96H15Espacenet
JP 2025147176 A2025-10-0614661Q96H15Espacenet
JP 2025529142 A2025-09-044670Q96H15Espacenet
US 12384828 B22025-08-1286Q96H15Espacenet
US 12371689 B22025-07-294670Q96H15Espacenet
JP 2025519096 A2025-06-24359Q96H15Espacenet

1 to 10 of 64

See all 64 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,103

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTIMD4 papersNewest fiscal year
P01AI039671Costimulatory Mechanisms of Autoimmunity72025
P30CA008748Cancer Center Support Grant62025
P30DK063491Diabetes Research Center (DRC)62025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
R01DK062357HuR/HIF – SIRT1 Signaling Axis in Liver Transplant Rejuvenation42025
T32AI007533Training in Molecular Virology, Viral Pathogenesis and Viral Vectors42025
P01AI120944Innate-Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury32025
P30AI027767UAB Center for AIDS Research (CFAR)32025
P30CA014195Cancer Center Support Grant (CCSG)32025
R01CA187975Regulation of stem-like CD8+ T cells and their role in immunotherapy32025

1 to 10 of 1,103Source NIH's project files

See all 1,103 nih grants

Papers1,396

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Timd4+ cardiac resident macrophages promote neutrophil chemotaxis and exacerbate sepsis-associated myocardial injury.Int Immunopharmacol202642735472PubTator, text miningPubMed
Multi-omics integration reveals TIM-4 as a master regulatory hub of neuroinflammation and neuronal cell death.Front Cell Dev Biol202642698755PubTator, text miningPubMed
Efferocytosis failure in chronic rhinosinusitis with nasal polyps: receptor-level mechanisms of unresolved type 2 inflammation.Front Immunol202642662713PubTator, text miningPubMed
Flow Cytometry Analysis of Gangliosides Expressed on Extracellular Vesicles.Methods Mol Biol202642613537PubTator, text miningPubMed
[Study on Huanglian Jiedu Decoction improving ox-LDL-induced LC3-related phagocytosis dysfunction in RAW264.7 macrophages by activating ERK5].Zhongguo Zhong Yao Za Zhi202642543371PubTator, text miningPubMed
Short histological kaleidoscope - recent findings in histology. Part VI. Kupffer cells, hepatic stellate cells, enteroendocrine cells, and telocytes.Rom J Morphol Embryol202642402735PubTator, text miningPubMed
Multi-layered functional genomics prioritizes candidate effectors and regulatory mechanisms of ankylosing spondylitis.Front Immunol202642305533PubTator, text miningPubMed
Integrated multi-omics strategies for identifying novel therapies in psoriasis.Bioinformatics202642209436PubTator, text miningPubMed
The spleen-heart crosstalk in cardiovascular disease: integrating neural, immune, and secretory pathways.Acta Pharmacol Sin202642185683PubTator, text miningPubMed
Cellular composition of tissue-resident monocyte-lineage cells reveals transcriptional heterogeneity during inflammatory arthritis.J Immunol202642118107PubTator, text miningPubMed

1 to 10 of 1,396

See all 1,396 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/91937

GET https://conductscience.org/api/genes/v1/91937/patents?page=2