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CD4: CD4 molecule

1 protein, 331 patents, 10 drugs, 22 trials, 57,715 NIH grants and 324,266 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCD4HGNC
NameCD4 moleculeHGNC
NCBI Gene ID920NCBI Gene
HGNC IDHGNC:1678HGNC
EnsemblENSG00000010610NCBI Gene
AliasesCD4mut, IMD79, Leu-3, OKT4D, T4NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01730T-cell surface glycoprotein CD445884Ensembl, GeneID, HGNCUniProt

Patents 331

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4831196 A22026-10-2813P01730Espacenet
EP 4806462 A22026-09-1612P01730Espacenet
WO 2026167079 A12026-08-133P01730Espacenet
WO 2026167093 A12026-08-1348P01730Espacenet
WO 2026167100 A12026-08-13115P01730Espacenet
EP 4778530 A22026-07-221P01730Espacenet
WO 2026128487 A12026-06-18593P01730Espacenet
EP 4753741 A12026-06-10479P01730Espacenet
EP 4750486 A22026-06-03132P01730Espacenet
US 12624087 B22026-05-1213P01730Espacenet

Drugs 10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CEDELIZUMABCHEMBL2108266T-cell surface antigen CD4 inhibitorINHIBITORChEMBL
CLENOLIXIMABCHEMBL2108187T-cell surface antigen CD4 inhibitorINHIBITORChEMBL
IBALIZUMABCHEMBL1743029T-cell surface antigen CD4 inhibitorINHIBITORChEMBL
KELIXIMABCHEMBL2108489T-cell surface antigen CD4 negative modulatorNEGATIVE MODULATORChEMBL
PRILIXIMABCHEMBL2108475T-cell surface antigen CD4 negative modulatorNEGATIVE MODULATORChEMBL
SEMZUVOLIMABCHEMBL4297846T-cell surface antigen CD4 inhibitorINHIBITORChEMBL
TREGALIZUMABCHEMBL1743083T-cell surface antigen CD4 agonistAGONISTChEMBL
TRX-1CHEMBL2109474T-cell surface antigen CD4 inhibitorINHIBITORChEMBL
VRC-01LSCHEMBL4298127T-cell surface antigen CD4 binding agentBINDING AGENTChEMBL
ZANOLIMUMABCHEMBL2108063T-cell surface antigen CD4 otherOTHERChEMBL

Trials 22

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05495204IBALIZUMABClinicalTrials.gov
NCT04673591TREGALIZUMABPHASE2ClinicalTrials.gov
NCT04620291SEMZUVOLIMABPHASE1ClinicalTrials.gov
NCT03743376SEMZUVOLIMABPHASE2ClinicalTrials.gov
NCT03707977VRC-01LSPHASE1/PHASE22023-02-14ClinicalTrials.gov
NCT02840474VRC-01LSPHASE12021-02-23ClinicalTrials.gov
NCT02369146SEMZUVOLIMABPHASE2ClinicalTrials.gov
NCT02028819IBALIZUMABClinicalTrials.gov
NCT01999192TREGALIZUMABPHASE22017-08-24ClinicalTrials.gov
NCT01668043SEMZUVOLIMABPHASE2ClinicalTrials.gov

NIH grants 57715

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30AI050410The University of North Carolina Center for AIDS Research1,2002,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research1,0552,025NIH's project files
P30CA008748Cancer Center Support Grant9962,025NIH's project files
P30AI027757University of Washington/Fred Hutch Center for AIDS Research9322,025NIH's project files
P30CA016672Cancer Center Support Grant7172,025NIH's project files
P30AI060354Harvard University Center for AIDS Research6982,025NIH's project files
P30AI094189The Johns Hopkins Center for AIDS Research (JHU CFAR)6542,025NIH's project files
P30AI050409Center for AIDS Research at Emory University5982,025NIH's project files
P30AI027767UAB Center for AIDS Research (CFAR)5822,025NIH's project files
UM1AI068636Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections5812,025NIH's project files

Papers 324266

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827453PubTator, text miningPubMed
42827183PubTator, text miningPubMed
42826859PubTator, text miningPubMed
42826489PubTator, text miningPubMed
42826196PubTator, text miningPubMed
42826053PubTator, text miningPubMed
42826002PubTator, text miningPubMed
42825904PubTator, text miningPubMed
42825902PubTator, text miningPubMed
42825901PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license