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Gene · 9211

LGI1: leucine rich glioma inactivated 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LGI1: leucine rich glioma inactivated 1. Genes, record 9211. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9211

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Gene

Symbol
LGI1
HGNC
Name
leucine rich glioma inactivated 1
HGNC
NCBI Gene ID
9211
NCBI Gene
HGNC ID
HGNC:6572
HGNC
Ensembl
ENSG00000108231
NCBI Gene
Aliases
ADLTE, ADPAEF, ADPEAF, DEE121, EPITEMPIN, EPT, ETL1, IB1099
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95970Leucine-rich glioma-inactivated protein 15579Ensembl, GeneID, HGNC

Source UniProt

Patents124

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451405O95970Espacenet
EP 4650780 A22025-11-198941O95970Espacenet
EP 4641201 A22025-10-299193O95970Espacenet
JP 2025147176 A2025-10-067817O95970Espacenet
JP 2025529142 A2025-09-046884O95970Espacenet
WO 2025166063 A12025-08-0716O95970Espacenet
US 12371689 B22025-07-296884O95970Espacenet
JP 2025517969 A2025-06-129193O95970Espacenet
JP 2025517970 A2025-06-128941O95970Espacenet
EP 4551941 A22025-05-1428O95970Espacenet

1 to 10 of 124

See all 124 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants526

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLGI1 papersNewest fiscal year
R01NS126227Seronegative Autoimmune Encephalopathies: Biomarker Discovery, Validation & Deep Phenotyping92025
UL1TR001863Yale Clinical and Translational Science Award72025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study32025
P30AG066444Alzheimer's Disease Research Center32025
R01NS029709Excitability and Plasticity of Developing Epileptic Brain32025
P01AI073693Anti-NMDA Receptor Antibodies in Adult Brain Dysfunction: Lessons from Lupus22025
P30AG062677Mayo Alzheimer's Disease Research Center22025
P30CA008748Cancer Center Support Grant22025
P30CA016056Roswell Park Cancer Center Support Grant22025
P30CA034196Cancer Center Support (CORE) Grant22025

1 to 10 of 526Source NIH's project files

See all 526 nih grants

Papers3,019

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Immune dysregulation and epileptogenesis.Neurol Sci202642820995PubTator, text miningPubMed
Beyond Nerve Hyperexcitability: Potential Implications of Cerebrospinal Fluid CASPR2 Antibodies for Central Pain Processing in Isaacs Syndrome: A Case-Based Systematic Review.Pain Ther202642809178PubTator, text miningPubMed
Autoimmune encephalitis and gastrointestinal inflammation: Building evidence for a gut-brain connection.J Neuroimmunol202642785101PubTator, text miningPubMed
Antibody-Dependent Cellular Phagocytosis and Cytotoxicity in Patients With LGI1 and CASPR2 Encephalitis.Neurol Neuroimmunol Neuroinflamm202642777167PubTator, text miningPubMed
Structural Brain Changes Are Linked to Clinical and Cognitive Outcomes in Anti-LGI1 Encephalitis.Neurol Neuroimmunol Neuroinflamm202642753224PubTator, text miningPubMed
Hippocampal texture asymmetry features on 18F-FDG PET differentiating anti-LGI1 and anti-GABABR encephalitis.Front Immunol202642712541PubTator, text miningPubMed
Autoimmune Encephalitis: A Case Series from a Tertiary Care Center in South India.Neurol India202642700126PubTator, text miningPubMed
Olfactory Hallucinations as the Initial Symptom of Anti-Leucine-Rich Glioma-Inactivated 1 Antibody Encephalitis: A Case Report and Review of the Literature.Cureus202642688849PubTator, text miningPubMed
Autoimmune-associated epilepsy: definitions and diagnosis - a narrative review.Arq Neuropsiquiatr202642674427PubTator, text miningPubMed
[Anti-LGI1 antibody encephalitis: A monocentric retrospective series of seven patients].Rev Med Interne202642660711PubTator, text miningPubMed

1 to 10 of 3,019

See all 3,019 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9211

GET https://conductscience.org/api/genes/v1/9211/patents?page=2