ConductScience.org, home

Library / Genes

AURKB: aurora kinase B

1 protein, 75 patents, 18 drugs, 60 trials, 3,987 NIH grants and 7,786 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolAURKBHGNC
Nameaurora kinase BHGNC
NCBI Gene ID9212NCBI Gene
HGNC IDHGNC:11390HGNC
EnsemblENSG00000178999NCBI Gene
AliasesAIK2, AIM-1, AIM1, ARK-2, ARK2, Aik2, AurB, IPL1, PPP1R48, STK-1, STK12, STK5, aurkb-sv1, aurkb-sv2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q96GD4Aurora kinase B3441Ensembl, GeneID, HGNCUniProt

Patents 75

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12661384 B22026-06-236Q96GD4Espacenet
EP 4641202 A22025-10-298913Q96GD4Espacenet
JP 2025062604 A2025-04-147920Q96GD4Espacenet
KR 1020250017231 A2025-02-048913Q96GD4Espacenet
EP 4487869 A22025-01-0815Q96GD4Espacenet
JP 2024123008 A2024-09-104974Q96GD4Espacenet
JP 2024123008 A2024-09-104976Q96GD4Espacenet
JP 2024523046 A2024-06-2522Q96GD4Espacenet
KR 1020240027895 A2024-03-04212Q96GD4Espacenet
US 11892452 B22024-02-062Q96GD4Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMG-900CHEMBL2140408Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
AT-9283CHEMBL495727Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORChEMBL
BARASERTIBCHEMBL415049Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORChEMBL
BI-811283CHEMBL3545395Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORChEMBL
CENISERTIBCHEMBL1967878Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
CYC-116CHEMBL482967Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
DANUSERTIBCHEMBL402548Serine/threonine-protein kinase Aurora inhibitorINHIBITORChEMBL
ENMD-2076CHEMBL482968Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORChEMBL
GSK-1070916CHEMBL1090479Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORChEMBL
IBCASERTIBCHEMBL5095033Serine/threonine-protein kinase Aurora-B inhibitorINHIBITORChEMBL

Trials 60

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07445295IBCASERTIBPHASE3ClinicalTrials.gov
NCT06492915IBCASERTIBPHASE2ClinicalTrials.gov
NCT05505825IBCASERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT05497843IBCASERTIBPHASE2ClinicalTrials.gov
NCT05371899IBCASERTIBClinicalTrials.gov
NCT05336721IBCASERTIBPHASE2ClinicalTrials.gov
NCT05271292IBCASERTIBPHASE1/PHASE2ClinicalTrials.gov
NCT04921527IBCASERTIBPHASE3ClinicalTrials.gov
NCT04830813IBCASERTIBPHASE3ClinicalTrials.gov
NCT04745689BARASERTIBPHASE22025-03-27ClinicalTrials.gov

NIH grants 3987

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant682,025NIH's project files
P30CA008748Cancer Center Support Grant352,025NIH's project files
P30CA016359Cancer Center Support Grant292,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase222,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant162,025NIH's project files
P30CA015704Cancer Center Support Grant152,025NIH's project files
P30CA016058Cancer Center Support Grant132,025NIH's project files
P30CA023108Cancer Center Support Grant122,025NIH's project files
P50CA116201Mayo Clinic Breast Cancer SPORE122,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center112,025NIH's project files

Papers 7786

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42775268PubTator, text miningPubMed
42763899PubTator, text miningPubMed
42749426PubTator, text miningPubMed
42749405PubTator, text miningPubMed
42711224PubTator, text miningPubMed
42685875PubTator, text miningPubMed
42681084PubTator, text miningPubMed
42648234PubTator, text miningPubMed
42636804PubTator, text miningPubMed
42634370PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license