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Gene · 923

CD6: CD6 molecule

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CD6: CD6 molecule. Genes, record 923. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/923

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Gene

Symbol
CD6
HGNC
Name
CD6 molecule
HGNC
NCBI Gene ID
923
NCBI Gene
HGNC ID
HGNC:1691
HGNC
Ensembl
ENSG00000013725
NCBI Gene
Aliases
TP120, Tp120
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P30203T-cell differentiation antigen CD66681Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440601P30203Espacenet
EP 4650780 A22025-11-195484P30203Espacenet
EP 4640849 A22025-10-29775P30203Espacenet
EP 4641201 A22025-10-295096P30203Espacenet
JP 2025147176 A2025-10-062397P30203Espacenet
JP 2025531671 A2025-09-256P30203Espacenet
JP 2025529142 A2025-09-04828P30203Espacenet
JP 2025529142 A2025-09-045787P30203Espacenet
US 12371689 B22025-07-295787P30203Espacenet
US 12371689 B22025-07-29828P30203Espacenet

1 to 10 of 54

See all 54 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ITOLIZUMABCHEMBL1743033T-cell differentiation antigen CD6 inhibitorINHIBITORChEMBL
ONCOLYSIN CD6CHEMBL2109485T-cell differentiation antigen CD6 binding agentBINDING AGENTChEMBL

Trials9

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05986162ITOLIZUMABPHASE1ClinicalTrials.gov
NCT05978544ITOLIZUMABPHASE1ClinicalTrials.gov
NCT05823675ITOLIZUMABPHASE1ClinicalTrials.gov
NCT05263999ITOLIZUMABPHASE3ClinicalTrials.gov
NCT04605926ITOLIZUMABPHASE3ClinicalTrials.gov
NCT04475588ITOLIZUMABPHASE22021-05-20ClinicalTrials.gov
NCT04128579ITOLIZUMABPHASE12025-04-18ClinicalTrials.gov
NCT04007198ITOLIZUMABPHASE12025-04-18ClinicalTrials.gov
NCT03763318ITOLIZUMABPHASE1/PHASE22025-04-18ClinicalTrials.gov

NIH grants1,131

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCD6 papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
T32AR007080Scientist Training in Rheumatology Research52025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA016672Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
R01EY034077Role of CDCP1 in the pathogenesis of autoimmune uveitis42025
P01AI039671Costimulatory Mechanisms of Autoimmunity32025
P01CA018029Adult Leukemia Research Center32025
P30AI027763UCSF-Bay Area Center for AIDS Research32025
P30CA043703Case Comprehensive Cancer Center Support Grant32025

1 to 10 of 1,131Source NIH's project files

See all 1,131 nih grants

Papers1,942

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Association of Vitamin D Levels and Systemic Inflammation in Patients with Hashimoto's Thyroiditis.Diseases202642783242PubTator, text miningPubMed
FOXP1 Knockdown Reprograms Th9 CAR-T Cells to Overcome Antigen Escape.Adv Sci (Weinh)202642750117PubTator, text miningPubMed
Acute effects of high-dose corticosteroids on serum biomarker profiles in primary CNS demyelinating disease: A pilot study.Mult Scler J Exp Transl Clin202642719441PubTator, text miningPubMed
Inflammatory Serum Olink Proteomics in Cancer-Related Pain Treated with Opioids: A Pilot Cross-Sectional and Longitudinal Study.J Proteome Res202642695881PubTator, text miningPubMed
Anti-CD6 monoclonal antibody UMCD6 induces CD6 internalization, remodels costimulatory receptor availability, and modulates CD4+ T-cell activation.Front Immunol202642688261PubTator, text miningPubMed
CD6-Directed Immunotherapy Targets Breast Cancer Stem Cell Function and Enhances Immune-Mediated Cytotoxicity in Triple-Negative Breast Cancer.Biomolecules202642650869PubTator, text miningPubMed
Immunotherapy of cancer without induction of autoimmunity - CD6 as a therapeutic target.Front Immunol202642643866PubTator, text miningPubMed
Impact of Gestational Maternal SARS-CoV-2 Infection on Neonatal Inflammatory Biomarkers.Am J Reprod Immunol202642640037PubTator, text miningPubMed
Genetic analysis of inflammatory proteins following BCG vaccination in Danish children.Biomed Pharmacother202642594746PubTator, text miningPubMed
[Bidirectional two-sample MR analysis of causal relationships between human inflammatory proteins and HS and keloids].Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi202642547441PubTator, text miningPubMed

1 to 10 of 1,942

See all 1,942 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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