Gene · 9232
PTTG1: PTTG1 regulator of sister chromatid separation, securin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PTTG1: PTTG1 regulator of sister chromatid separation, securin. Genes, record 9232. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9232
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95997 | Securin | 202 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents108
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 58078 | O95997 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58079 | O95997 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 58080 | O95997 | Espacenet |
| WO 2025262108 A1 | 2025-12-26 | 14 | O95997 | Espacenet |
| JP 2025172069 A | 2025-11-20 | 767 | O95997 | Espacenet |
| JP 2025172069 A | 2025-11-20 | 769 | O95997 | Espacenet |
| JP 2025172069 A | 2025-11-20 | 770 | O95997 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6933 | O95997 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5196 | O95997 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6933 | O95997 | Espacenet |
1 to 10 of 108
See all 108 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,474
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PTTG1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 13 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 12 | 2025 |
| R35GM128855 | Spindle Assembly Checkpoint Silencing | 10 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 9 | 2025 |
| P50CA058223 | SPORE in Breast Cancer | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| R01ES027778 | Mechanism for arsenic induced carcinogenesis | 5 | 2025 |
| R01GM074215 | Kinetochore Specification and Function | 5 | 2025 |
| R35GM118053 | Regulatory Enzymes and Systems in Cell Cycle Control | 5 | 2025 |
| ZIABC011191 | Preclinical Mouse Models of Thyroid Cancer | 5 | 2025 |
1 to 10 of 1,474Source NIH's project files
See all 1,474 nih grantsPapers3,322
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Multimodal integration of pathomics and single-cell transcriptomics reveals CDC20 as a link between prostate cancer recurrence and benzo[a]pyrene-responsive phenotypes. | Front Cell Dev Biol | 2026 | 42787166 | PubTator, text mining | PubMed |
| The PTTG1/AURKA Axis Drives Acquired Anlotinib Resistance in Non-Small Cell Lung Cancer by Remodeling the Tumor Immune Microenvironment. | Biofactors | 2026 | 42765160 | PubTator, text mining | PubMed |
| Identification of functional genes and immune cell infiltration analysis in liposarcoma. | PLoS One | 2026 | 42726806 | PubTator, text mining | PubMed |
| An oxidative stress - and immunotherapy-related six-gene signature defines immune subtypes and predicts prognosis and immunotherapy response in hepatocellular carcinoma. | Gene | 2026 | 42551718 | PubTator, text mining | PubMed |
| Pandoomain, a scalable pipeline for genomic and protein domain context analysis, reveals widespread PT-TG domain architectural diversity and novel polymorphic toxins. | mSystems | 2026 | 42530337 | PubTator, text mining | PubMed |
| An Interpretable Four-Gene Cell-Cycle Signature Links Malignant Progression to Adverse Survival in Adult Primary Diffuse Glioma: A CGGA Transcriptome Study. | Genes (Basel) | 2026 | 42510873 | PubTator, text mining | PubMed |
| Clinical and prognostic implications of pituitary tumor-transforming gene 1 in solid tumors. | Front Oncol | 2026 | 42434759 | PubTator, text mining | PubMed |
| Multi-state modeling associates proliferation genes with early estrogen receptor-positive breast cancer recurrence and survival. | Res Sq | 2026 | 42427829 | PubTator, text mining | PubMed |
| Hyperlactataemia in lymphoma-associated haemophagocytic lymphohistiocytosis: Linked to monocytic glycolysis and adverse prognosis. | Br J Haematol | 2026 | 42384015 | PubTator, text mining | PubMed |
| A Telomere-Maintenance Three-Gene Model for the Prognostic Prediction in Intrahepatic Cholangiocarcinoma and Multi-Cohort Validation. | Curr Gene Ther | 2026 | 42220126 | PubTator, text mining | PubMed |
1 to 10 of 3,322
See all 3,322 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9232
GET https://conductscience.org/api/genes/v1/9232/patents?page=2