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Gene · 9232

PTTG1: PTTG1 regulator of sister chromatid separation, securin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTTG1: PTTG1 regulator of sister chromatid separation, securin. Genes, record 9232. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9232

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Gene

Symbol
PTTG1
HGNC
Name
PTTG1 regulator of sister chromatid separation, securin
HGNC
NCBI Gene ID
9232
NCBI Gene
HGNC ID
HGNC:9690
HGNC
Ensembl
ENSG00000164611
NCBI Gene
Aliases
EAP1, ECRAR, HPTTG, PTTG, TUTR1, securin
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95997Securin2022Ensembl, GeneID, HGNC

Source UniProt

Patents108

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458078O95997Espacenet
JP 2026004568 A2026-01-1458079O95997Espacenet
JP 2026004568 A2026-01-1458080O95997Espacenet
WO 2025262108 A12025-12-2614O95997Espacenet
JP 2025172069 A2025-11-20767O95997Espacenet
JP 2025172069 A2025-11-20769O95997Espacenet
JP 2025172069 A2025-11-20770O95997Espacenet
EP 4650780 A22025-11-196933O95997Espacenet
EP 4641202 A22025-10-295196O95997Espacenet
JP 2025517970 A2025-06-126933O95997Espacenet

1 to 10 of 108

See all 108 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,474

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTTG1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant132025
P30CA016086Cancer Center Support Grant122025
R35GM128855Spindle Assembly Checkpoint Silencing102025
P30CA021765Cancer Center Support Grant (CCSG)92025
P50CA058223SPORE in Breast Cancer92025
P30CA008748Cancer Center Support Grant52025
R01ES027778Mechanism for arsenic induced carcinogenesis52025
R01GM074215Kinetochore Specification and Function52025
R35GM118053Regulatory Enzymes and Systems in Cell Cycle Control52025
ZIABC011191Preclinical Mouse Models of Thyroid Cancer52025

1 to 10 of 1,474Source NIH's project files

See all 1,474 nih grants

Papers3,322

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multimodal integration of pathomics and single-cell transcriptomics reveals CDC20 as a link between prostate cancer recurrence and benzo[a]pyrene-responsive phenotypes.Front Cell Dev Biol202642787166PubTator, text miningPubMed
The PTTG1/AURKA Axis Drives Acquired Anlotinib Resistance in Non-Small Cell Lung Cancer by Remodeling the Tumor Immune Microenvironment.Biofactors202642765160PubTator, text miningPubMed
Identification of functional genes and immune cell infiltration analysis in liposarcoma.PLoS One202642726806PubTator, text miningPubMed
An oxidative stress - and immunotherapy-related six-gene signature defines immune subtypes and predicts prognosis and immunotherapy response in hepatocellular carcinoma.Gene202642551718PubTator, text miningPubMed
Pandoomain, a scalable pipeline for genomic and protein domain context analysis, reveals widespread PT-TG domain architectural diversity and novel polymorphic toxins.mSystems202642530337PubTator, text miningPubMed
An Interpretable Four-Gene Cell-Cycle Signature Links Malignant Progression to Adverse Survival in Adult Primary Diffuse Glioma: A CGGA Transcriptome Study.Genes (Basel)202642510873PubTator, text miningPubMed
Clinical and prognostic implications of pituitary tumor-transforming gene 1 in solid tumors.Front Oncol202642434759PubTator, text miningPubMed
Multi-state modeling associates proliferation genes with early estrogen receptor-positive breast cancer recurrence and survival.Res Sq202642427829PubTator, text miningPubMed
Hyperlactataemia in lymphoma-associated haemophagocytic lymphohistiocytosis: Linked to monocytic glycolysis and adverse prognosis.Br J Haematol202642384015PubTator, text miningPubMed
A Telomere-Maintenance Three-Gene Model for the Prognostic Prediction in Intrahepatic Cholangiocarcinoma and Multi-Cohort Validation.Curr Gene Ther202642220126PubTator, text miningPubMed

1 to 10 of 3,322

See all 3,322 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9232

GET https://conductscience.org/api/genes/v1/9232/patents?page=2