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Gene · 9252

RPS6KA5: ribosomal protein S6 kinase A5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RPS6KA5: ribosomal protein S6 kinase A5. Genes, record 9252. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9252

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Gene

Symbol
RPS6KA5
HGNC
Name
ribosomal protein S6 kinase A5
HGNC
NCBI Gene ID
9252
NCBI Gene
HGNC ID
HGNC:10434
HGNC
Ensembl
ENSG00000100784
NCBI Gene
Aliases
MSK1, MSPK1, RLPK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75582Ribosomal protein S6 kinase alpha-58028Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025032204 A2025-03-1135051O75582Espacenet
EP 4463571 A12024-11-20245O75582Espacenet
EP 4461818 A22024-11-1335051O75582Espacenet
JP 2023058610 A2023-04-2535051O75582Espacenet
US 11446398 B22022-09-2074447O75582Espacenet
JP 2022524081 A2022-04-27177418O75582Espacenet
US 11078247 B22021-08-039808O75582Espacenet
JP 2020508652 A2020-03-2635051O75582Espacenet
US 9878056 B22018-01-301570O75582Espacenet
JP 2017141230 A2017-08-175638O75582Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,374

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRPS6KA5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant62025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
P30CA008748Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P30DK063491Diabetes Research Center (DRC)42025
R01NS027699Molecular Studies of Spinocerebellar Ataxia Type 142025
P01CA108671Myeloproliferative Neoplasms-Research Consortium32025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA044579University of Virginia Cancer Center Support Grant32025
P30CA076292Moffitt Cancer Center Support Grant32025

1 to 10 of 1,374Source NIH's project files

See all 1,374 nih grants

Papers1,701

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Stress- and mitosis-dependent phosphorylation of NIFK on Ser247.J Cell Sci202642504587PubTator, text miningPubMed
Neuroinflammation promotes the development of pharmacoresistant epilepsy by triggering the MSK1/CREB signaling pathway.Sci Rep202642031786PubTator, text miningPubMed
α-mangostin, a xanthone from garcinia mangostana fruit inhibits MEK1 kinase in prostate cancer.Nat Prod Res202641964468PubTator, text miningPubMed
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.Signal Transduct Target Ther202641881983PubTator, text miningPubMed
ERKed by too much signaling: from oncogenic driver to therapeutic vulnerability.Cell Mol Life Sci202641865130PubTator, text miningPubMed
ZDHHC9 palmitoylates LAMTOR1 to promote renal cell carcinoma malignant progression.Cell Death Dis202641856969PubTator, text miningPubMed
Brain Permeable SGK1 Inhibitors: A Promising Therapeutic Strategy for Neurodegenerative Diseases.J Med Chem202641837733PubTator, text miningPubMed
Folinic Acid Improves Healing of Diabetic Foot Ulcers.Wound Repair Regen202641795141PubTator, text miningPubMed
Exploitation of CREB signaling by HTLV-1 and BLV: A central axis in viral persistence and leukemogenesis.Med Oncol202641774334PubTator, text miningPubMed
Defining the Active Conformation of Typical Protein Kinase Domains from Substrate-Bound PDB Structures Enables Active-State AlphaFold2 Models for All 437 Human Catalytic Protein Kinases.bioRxiv202641757035PubTator, text miningPubMed

1 to 10 of 1,701

See all 1,701 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9252

GET https://conductscience.org/api/genes/v1/9252/patents?page=2