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Gene · 92521

SPECC1: sperm antigen with calponin homology and coiled-coil domains 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SPECC1: sperm antigen with calponin homology and coiled-coil domains 1. Genes, record 92521. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/92521

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Gene

Symbol
SPECC1
HGNC
Name
sperm antigen with calponin homology and coiled-coil domains 1
HGNC
NCBI Gene ID
92521
NCBI Gene
HGNC ID
HGNC:30615
HGNC
Ensembl
ENSG00000128487
NCBI Gene
Aliases
CYTSB, FLJ36955, HCMOGT-1, HCMOGT1, NSP, NSP5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q5M775Cytospin-B1,0680Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465138Q5M775Espacenet
EP 4650780 A22025-11-191906Q5M775Espacenet
EP 4641201 A22025-10-291494Q5M775Espacenet
JP 2025517969 A2025-06-121494Q5M775Espacenet
JP 2025517970 A2025-06-121906Q5M775Espacenet
JP 2025032204 A2025-03-1136366Q5M775Espacenet
JP 2025032204 A2025-03-1136373Q5M775Espacenet
EP 4461818 A22024-11-1336366Q5M775Espacenet
EP 4461818 A22024-11-1336373Q5M775Espacenet
JP 2023058610 A2023-04-2536366Q5M775Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,071

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSPECC1 papersNewest fiscal year
R01AI080656Regulation of Rotavirus Replication152025
P30DK056338Texas Medical Center Digestive Diseases Center112025
R01AI158775Development of dual inhibitors targeting the viral main protease and the host cathepsin L as SARS-CoV-2 antivirals82025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant72025
U19AI135972SARS-CoV adaptations through a Systems Biology Lens (SYBIL)72025
P30CA023168Cancer Center Support Grant62025
P30GM133893Center for Biomolecular Structure (CBMS)62025
P30CA068485Cancer Center Support Grant52025
P30DK052574Host-environment interactions in the pathophysiology of digestive disease52025
R01AI036040STRUCTURAL STUDIES ON ROTAVIRUS52025

1 to 10 of 1,071Source NIH's project files

See all 1,071 nih grants

Papers3,158

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
HPLC-HRMS/MS Characterization, Molecular Docking, and Comparative Genotoxicity of Free and Liposome-Encapsulated Aesculus hippocastanum Seed Extract.Int J Mol Sci202642794799PubTator, text miningPubMed
Serine ubiquitination of the SARS-CoV-2 RdRp by the non-canonical E3 ligase MYCBP2.mSphere202642678169PubTator, text miningPubMed
Human Coronavirus Photodynamic Inactivation and In Silico Mechanisms Induced by Ga(III) vs. Zn(II) Phthalocyanines.Viruses202642655636PubTator, text miningPubMed
PRRSV suppresses ER-phagy through Nsp2- and Nsp5-mediated degradation of FAM134B.Front Cell Infect Microbiol202642620616PubTator, text miningPubMed
Highly potent antiviral drug candidates targeting SARS-CoV-2 nsp3 and nsp5.Biomed Pharmacother202642551189PubTator, text miningPubMed
Beyond the catalytic site: Structural characterization of MERS-CoV nsp5 and its druggable binding pockets.J Mol Graph Model202642520494PubTator, text miningPubMed
Molecular Epidemiological Survey of Porcine Rotavirus in the Guangxi Region from 2020 to 2025 and Isolation and Identification of the G9P[23] Strain CH-GXGL-PoRV-3151-2021.Vet Sci202642514641PubTator, text miningPubMed
Correction for Li et al., "PDCoV NSP5 cleaves the selective autophagy receptor CCDC50 to disrupt autophagic degradation of the viral envelope protein".mBio202642466866PubTator, text miningPubMed
Super-resolution atlas of SARS-CoV-2 infection reveals protease-dependent organelle maturation, dsRNA landscapes, and intracellular structural proteins.Nat Commun202642436145PubTator, text miningPubMed
A rotavirus vaccine candidate attenuated by codon deoptimization protects neonatal mice against wild-type virus infection.PLoS Pathog202642412727PubTator, text miningPubMed

1 to 10 of 3,158

See all 3,158 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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