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Gene · 9254

CACNA2D2: calcium voltage-gated channel auxiliary subunit alpha2delta 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CACNA2D2: calcium voltage-gated channel auxiliary subunit alpha2delta 2. Genes, record 9254. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9254

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Gene

Symbol
CACNA2D2
HGNC
Name
calcium voltage-gated channel auxiliary subunit alpha2delta 2
HGNC
NCBI Gene ID
9254
NCBI Gene
HGNC ID
HGNC:1400
HGNC
Ensembl
ENSG00000007402
NCBI Gene
Aliases
CACNA2D, CASVDD, KIAA0558, alpha2delta-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NY47Voltage-dependent calcium channel subunit alpha-2/delta-21,1500Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439572Q9NY47Espacenet
EP 4641201 A22025-10-2916532Q9NY47Espacenet
EP 4641202 A22025-10-297008Q9NY47Espacenet
JP 2025517969 A2025-06-1216532Q9NY47Espacenet
JP 2025062604 A2025-04-1410637Q9NY47Espacenet
JP 2025032204 A2025-03-1125551Q9NY47Espacenet
KR 1020250017231 A2025-02-047008Q9NY47Espacenet
EP 4461818 A22024-11-1325551Q9NY47Espacenet
JP 2023058610 A2023-04-2525551Q9NY47Espacenet
US 11446398 B22022-09-2010637Q9NY47Espacenet

1 to 10 of 19

See all 19 patents

Drugs13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL
BEPRIDIL HYDROCHLORIDECHEMBL1200382Voltage-gated calcium channel blockerBLOCKERChEMBL
GABAPENTINCHEMBL940Voltage-gated calcium channel modulatorMODULATORChEMBL
GABAPENTIN ENACARBILCHEMBL1628502Voltage-gated calcium channel modulatorMODULATORChEMBL
IMAGABALINCHEMBL2103836Voltage-gated calcium channel modulatorMODULATORChEMBL
MIROGABALINCHEMBL3545125Voltage-gated calcium channel alpha2/delta subunit 2 modulatorMODULATORChEMBL
MIROGABALIN BESYLATECHEMBL3545257Voltage-gated calcium channel alpha2/delta subunit 2 modulatorMODULATORChEMBL
PHLOROGLUCINOLCHEMBL473159Voltage-gated calcium channel blockerBLOCKERChEMBL
PREGABALINCHEMBL1059Voltage-gated calcium channel modulatorMODULATORChEMBL

1 to 10 of 13

See all 13 drugs

Trials385

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants423

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCACNA2D2 papersNewest fiscal year
P30AG066511Goizueta Alzheimer's Disease Research Center32025
P30CA016672Cancer Center Support Grant22025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors22025
R01NS126247Alpha2delta-mediated control of neuronal signaling22025
R35GM131760Computational Genomics of Signal Transduction22025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).22025
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro22025
F30OD031914MicroRNA-375 regulation of enteroendocrine cell biology in diet-induced obesity and bariatric surgery12025
IK4BX005219BLR&D Research Career Development Transition Award Application12025
K12HD028820Advancing Child Health Through Cellular and Molecular Biology12025

1 to 10 of 423Source NIH's project files

See all 423 nih grants

Papers536

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Calcium Channel Subunit Alpha2delta 2 Is Upregulated During Odontoblast-Like Differentiation and Exhibits Higher Basal Expression in Stem Cells From Exfoliated Deciduous Teeth Than in Dental Pulp Stem Cells.
Cureus202642669006PubTator, text miningPubMed
Calcium signaling pathway implicates a shared genetic basis between psychiatric and cardiovascular diseases.Transl Psychiatry202642436150PubTator, text miningPubMed
CSF proteome-wide study of neuropsychiatric symptoms of dementia.medRxiv202642428132PubTator, text miningPubMed
Ion Channel-Rho GTPase Coupling in Human Odontogenesis: Integrative Structural and Network Dissection of TRIO and CACNA2D2 Variants From Familial Tooth Agenesis.Cureus202642359198PubTator, text miningPubMed
Decoding the role of polyamine metabolism in lung adenocarcinoma prognosis: A triangulated approach combining transcriptome, single-cell and Mendelian randomization analyses.Oncol Lett202642256813PubTator, text miningPubMed
Familial Tooth Agenesis in Lebanese Patients: Clinical Characterization and Whole-Exome Identification of Rare CACNA2D2 and TRIO Variants.Cureus202642255799PubTator, text miningPubMed
Integration of Single-Cell RNA Sequencing and Machine Learning to Identify and Validate Prognostic Genes With Lymph Node Metastasis and Immune Cell Signatures in Lung Adenocarcinoma.FASEB J202641979566PubTator, text miningPubMed
Deciphering RTK-RAS and MAPK Pathway Dependencies in Gemcitabine-Treated Pancreatic Ductal Adenocarcinoma Through Conversational Artificial Intelligence.Int J Mol Sci202641977200PubTator, text miningPubMed
CACNA2D2 rs56287038:G>T and SCN1A rs2298771:C>T Variants Are Associated with Antiseizure Medication Response in Turkish Epilepsy Patients: A Pilot Study.Neuropsychobiology202641961764PubTator, text miningPubMed
Blockade of Presynaptic α2δ1-2 Subunits of Voltage-Gated Ca²⁺ Channels Attenuates Neurobiochemical and Sensorimotor Deficits After Traumatic Brain Injury in Mice.Neurochem Res202641880029PubTator, text miningPubMed

1 to 10 of 536

See all 536 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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