Gene · 9254
CACNA2D2: calcium voltage-gated channel auxiliary subunit alpha2delta 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CACNA2D2: calcium voltage-gated channel auxiliary subunit alpha2delta 2. Genes, record 9254. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9254
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NY47 | Voltage-dependent calcium channel subunit alpha-2/delta-2 | 1,150 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 39572 | Q9NY47 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 16532 | Q9NY47 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 7008 | Q9NY47 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 16532 | Q9NY47 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10637 | Q9NY47 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 25551 | Q9NY47 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 7008 | Q9NY47 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 25551 | Q9NY47 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 25551 | Q9NY47 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 10637 | Q9NY47 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs13
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ATAGABALIN | CHEMBL593430 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| BEPRIDIL | CHEMBL1008 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| BEPRIDIL HYDROCHLORIDE | CHEMBL1200382 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| GABAPENTIN | CHEMBL940 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| GABAPENTIN ENACARBIL | CHEMBL1628502 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| IMAGABALIN | CHEMBL2103836 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| MIROGABALIN | CHEMBL3545125 | Voltage-gated calcium channel alpha2/delta subunit 2 modulator | MODULATOR | ChEMBL |
| MIROGABALIN BESYLATE | CHEMBL3545257 | Voltage-gated calcium channel alpha2/delta subunit 2 modulator | MODULATOR | ChEMBL |
| PHLOROGLUCINOL | CHEMBL473159 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| PREGABALIN | CHEMBL1059 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
1 to 10 of 13
See all 13 drugsTrials385
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07606638 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07598474 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07429734 | GABAPENTIN | PHASE3 | ClinicalTrials.gov | |
| NCT07382921 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07344467 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07307170 | MIROGABALIN | ClinicalTrials.gov | ||
| NCT07230197 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07230171 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07208357 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07196657 | PREGABALIN | ClinicalTrials.gov |
1 to 10 of 385
See all 385 trialsNIH grants423
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CACNA2D2 papers | Newest fiscal year |
|---|---|---|---|
| P30AG066511 | Goizueta Alzheimer's Disease Research Center | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| P50AA022537 | Cross-species investigation of gene networks for ethanol-related behaviors | 2 | 2025 |
| R01NS126247 | Alpha2delta-mediated control of neuronal signaling | 2 | 2025 |
| R35GM131760 | Computational Genomics of Signal Transduction | 2 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 2 | 2025 |
| U19AI057229 | Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro | 2 | 2025 |
| F30OD031914 | MicroRNA-375 regulation of enteroendocrine cell biology in diet-induced obesity and bariatric surgery | 1 | 2025 |
| IK4BX005219 | BLR&D Research Career Development Transition Award Application | 1 | 2025 |
| K12HD028820 | Advancing Child Health Through Cellular and Molecular Biology | 1 | 2025 |
1 to 10 of 423Source NIH's project files
See all 423 nih grantsPapers536
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Calcium Channel Subunit Alpha2delta 2 Is Upregulated During Odontoblast-Like Differentiation and Exhibits Higher Basal Expression in Stem Cells From Exfoliated Deciduous Teeth Than in Dental Pulp Stem Cells. | Cureus | 2026 | 42669006 | PubTator, text mining | PubMed |
| Calcium signaling pathway implicates a shared genetic basis between psychiatric and cardiovascular diseases. | Transl Psychiatry | 2026 | 42436150 | PubTator, text mining | PubMed |
| CSF proteome-wide study of neuropsychiatric symptoms of dementia. | medRxiv | 2026 | 42428132 | PubTator, text mining | PubMed |
| Ion Channel-Rho GTPase Coupling in Human Odontogenesis: Integrative Structural and Network Dissection of TRIO and CACNA2D2 Variants From Familial Tooth Agenesis. | Cureus | 2026 | 42359198 | PubTator, text mining | PubMed |
| Decoding the role of polyamine metabolism in lung adenocarcinoma prognosis: A triangulated approach combining transcriptome, single-cell and Mendelian randomization analyses. | Oncol Lett | 2026 | 42256813 | PubTator, text mining | PubMed |
| Familial Tooth Agenesis in Lebanese Patients: Clinical Characterization and Whole-Exome Identification of Rare CACNA2D2 and TRIO Variants. | Cureus | 2026 | 42255799 | PubTator, text mining | PubMed |
| Integration of Single-Cell RNA Sequencing and Machine Learning to Identify and Validate Prognostic Genes With Lymph Node Metastasis and Immune Cell Signatures in Lung Adenocarcinoma. | FASEB J | 2026 | 41979566 | PubTator, text mining | PubMed |
| Deciphering RTK-RAS and MAPK Pathway Dependencies in Gemcitabine-Treated Pancreatic Ductal Adenocarcinoma Through Conversational Artificial Intelligence. | Int J Mol Sci | 2026 | 41977200 | PubTator, text mining | PubMed |
| CACNA2D2 rs56287038:G>T and SCN1A rs2298771:C>T Variants Are Associated with Antiseizure Medication Response in Turkish Epilepsy Patients: A Pilot Study. | Neuropsychobiology | 2026 | 41961764 | PubTator, text mining | PubMed |
| Blockade of Presynaptic α2δ1-2 Subunits of Voltage-Gated Ca²⁺ Channels Attenuates Neurobiochemical and Sensorimotor Deficits After Traumatic Brain Injury in Mice. | Neurochem Res | 2026 | 41880029 | PubTator, text mining | PubMed |
1 to 10 of 536
See all 536 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9254
GET https://conductscience.org/api/genes/v1/9254/patents