Gene · 9261
MAPKAPK2: MAPK activated protein kinase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MAPKAPK2: MAPK activated protein kinase 2. Genes, record 9261. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9261
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49137 | MAP kinase-activated protein kinase 2 | 400 | 31 | Ensembl, GeneID, HGNC |
Source UniProt
Patents56
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026505836 A | 2026-02-18 | 1 | P49137 | Espacenet |
| JP 2026505837 A | 2026-02-18 | 1 | P49137 | Espacenet |
| JP 2026503867 A | 2026-02-02 | 1 | P49137 | Espacenet |
| EP 4661875 A1 | 2025-12-17 | 1 | P49137 | Espacenet |
| EP 4662207 A2 | 2025-12-17 | 1 | P49137 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8174 | P49137 | Espacenet |
| KR 1020250142407 A | 2025-09-30 | 1 | P49137 | Espacenet |
| KR 1020250139398 A | 2025-09-23 | 1 | P49137 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2537 | P49137 | Espacenet |
| EP 4608401 A2 | 2025-09-03 | 1 | P49137 | Espacenet |
1 to 10 of 56
See all 56 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| AT-13148 | CHEMBL3544960 | MAP kinase-activated protein kinase 2 inhibitor | INHIBITOR |
Source ChEMBL
Trials1
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted |
|---|---|---|---|
| NCT01585701 | AT-13148 | PHASE1 |
Source ClinicalTrials.gov
NIH grants2,214
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MAPKAPK2 papers | Newest fiscal year |
|---|---|---|---|
| U19AI057229 | Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro | 15 | 2025 |
| ZIAES090080 | TTP and related proteins in the regulation of gene expression | 15 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 5 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 5 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 5 | 2025 |
1 to 10 of 2,214Source NIH's project files
See all 2,214 nih grantsPapers3,346
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2-Mediated DNA Damage Response. | Adv Sci (Weinh) | 2026 | 42750169 | PubTator, text mining | PubMed |
| 5-Iodotubercidin inhibits epithelial to mesenchymal transition by inhibiting IKK/NFκB-dependent gene expression. | J Biol Chem | 2026 | 42727846 | PubTator, text mining | PubMed |
| A novel framework for the discovery of MAPK-activated protein kinase 2 (MAPKAPK2) inhibitors using a multi-feature deep learning ensemble. | J Comput Aided Mol Des | 2026 | 42700280 | PubTator, text mining | PubMed |
| Global Proteomic Analysis Reveals Inflammatory Pathway Modulation Associated with miR-146a in LPS-Stimulated Macrophages. | Int J Mol Sci | 2026 | 42511854 | PubTator, text mining | PubMed |
| A patent perspective of RSK inhibitors to treat cancer (2020-present). | Expert Opin Ther Pat | 2026 | 42508020 | PubTator, text mining | PubMed |
| Exploring the mechanism of Shuangyu Granule in regulating immune-inflammatory responses in influenza through UPLC-Orbitrap-MS/MS, GC-MS, and network target analysis. | PLoS One | 2026 | 42507727 | PubTator, text mining | PubMed |
| Versatile Detection of Cellular Protein via Fluorescence Anisotropy. | Adv Sci (Weinh) | 2026 | 42439473 | PubTator, text mining | PubMed |
| Ingenane diterpenoids with anti-inflammatory activity from the whole plants of Euphorbia peplus. | Phytochemistry | 2026 | 42392553 | PubTator, text mining | PubMed |
| Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation. | Cell Death Differ | 2026 | 42387067 | PubTator, text mining | PubMed |
| Lysophagy protects against ANXA11 amyloid fibril toxicity and propagation in FTLD. | Transl Neurodegener | 2026 | 42365390 | PubTator, text mining | PubMed |
1 to 10 of 3,346
See all 3,346 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9261
GET https://conductscience.org/api/genes/v1/9261/patents?page=2