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Gene · 9261

MAPKAPK2: MAPK activated protein kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAPKAPK2: MAPK activated protein kinase 2. Genes, record 9261. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9261

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Gene

Symbol
MAPKAPK2
HGNC
Name
MAPK activated protein kinase 2
HGNC
NCBI Gene ID
9261
NCBI Gene
HGNC ID
HGNC:6887
HGNC
Ensembl
ENSG00000162889
NCBI Gene
Aliases
MAPKAP-K2, MK-2, MK2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49137MAP kinase-activated protein kinase 240031Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026505836 A2026-02-181P49137Espacenet
JP 2026505837 A2026-02-181P49137Espacenet
JP 2026503867 A2026-02-021P49137Espacenet
EP 4661875 A12025-12-171P49137Espacenet
EP 4662207 A22025-12-171P49137Espacenet
EP 4650780 A22025-11-198174P49137Espacenet
KR 1020250142407 A2025-09-301P49137Espacenet
KR 1020250139398 A2025-09-231P49137Espacenet
JP 2025529142 A2025-09-042537P49137Espacenet
EP 4608401 A22025-09-031P49137Espacenet

1 to 10 of 56

See all 56 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
AT-13148CHEMBL3544960MAP kinase-activated protein kinase 2 inhibitorINHIBITOR

Source ChEMBL

Trials1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first posted
NCT01585701AT-13148PHASE1

NIH grants2,214

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAPKAPK2 papersNewest fiscal year
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro152025
ZIAES090080TTP and related proteins in the regulation of gene expression152025
P30CA016672Cancer Center Support Grant102025
P30CA014051Cancer Center Support (Core) Grant82025
P30CA008748Cancer Center Support Grant52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P30CA068485Cancer Center Support Grant52025
P30CA091842Cancer Center Support Grant52025
P30DK058404Molecular and Cellular Basis for Digestive Diseases52025
P30EY008126Core Grant in Vision Research52025

1 to 10 of 2,214Source NIH's project files

See all 2,214 nih grants

Papers3,346

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2-Mediated DNA Damage Response.Adv Sci (Weinh)202642750169PubTator, text miningPubMed
5-Iodotubercidin inhibits epithelial to mesenchymal transition by inhibiting IKK/NFκB-dependent gene expression.J Biol Chem202642727846PubTator, text miningPubMed
A novel framework for the discovery of MAPK-activated protein kinase 2 (MAPKAPK2) inhibitors using a multi-feature deep learning ensemble.J Comput Aided Mol Des202642700280PubTator, text miningPubMed
Global Proteomic Analysis Reveals Inflammatory Pathway Modulation Associated with miR-146a in LPS-Stimulated Macrophages.Int J Mol Sci202642511854PubTator, text miningPubMed
A patent perspective of RSK inhibitors to treat cancer (2020-present).Expert Opin Ther Pat202642508020PubTator, text miningPubMed
Exploring the mechanism of Shuangyu Granule in regulating immune-inflammatory responses in influenza through UPLC-Orbitrap-MS/MS, GC-MS, and network target analysis.PLoS One202642507727PubTator, text miningPubMed
Versatile Detection of Cellular Protein via Fluorescence Anisotropy.Adv Sci (Weinh)202642439473PubTator, text miningPubMed
Ingenane diterpenoids with anti-inflammatory activity from the whole plants of Euphorbia peplus.Phytochemistry202642392553PubTator, text miningPubMed
Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation.Cell Death Differ202642387067PubTator, text miningPubMed
Lysophagy protects against ANXA11 amyloid fibril toxicity and propagation in FTLD.Transl Neurodegener202642365390PubTator, text miningPubMed

1 to 10 of 3,346

See all 3,346 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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