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Gene · 9271

PIWIL1: piwi like RNA-mediated gene silencing 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PIWIL1: piwi like RNA-mediated gene silencing 1. Genes, record 9271. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9271

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Gene

Symbol
PIWIL1
HGNC
Name
piwi like RNA-mediated gene silencing 1
HGNC
NCBI Gene ID
9271
NCBI Gene
HGNC ID
HGNC:9007
HGNC
Ensembl
ENSG00000125207
NCBI Gene
Aliases
CT80.1, HIWI, MIWI, PIWI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96J94Piwi-like protein 18616Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458084Q96J94Espacenet
EP 4641201 A22025-10-29813Q96J94Espacenet
JP 2025517969 A2025-06-12813Q96J94Espacenet
JP 2025032204 A2025-03-1133491Q96J94Espacenet
JP 2025032204 A2025-03-1133497Q96J94Espacenet
EP 4461818 A22024-11-1333491Q96J94Espacenet
EP 4461818 A22024-11-1333497Q96J94Espacenet
KR 1020240156643 A2024-10-30350Q96J94Espacenet
JP 2024097033 A2024-07-1779Q96J94Espacenet
US 11666644 B22023-06-0679Q96J94Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,251

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePIWIL1 papersNewest fiscal year
P30CA045508CSHL Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant62025
P40OD010440Caenorhabditis Genetics Center62025
P01CA013106Targeting Transcription and Splicing in Cancer52025
P50HD096723Genetics of Male Infertility: Accelerating the pace of discovery52025
R35GM127090Structural and Mechanistic basis for RNA Silencing52025
ZIADK075111PIWI proteins and PIWI-interacting small RNAs guard the genomic integrity of germ cells52025
R01GM083300Selective regulatory and biogenesis mechanisms for microRNAs42025
R01HD078641Genomics of spermatogenic impairment42025
P01HL116263HDL Function in Human Disease32025

1 to 10 of 1,251Source NIH's project files

See all 1,251 nih grants

Papers2,375

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dual origins for neural cells during development of the Clytia planula larva.Development202642757688PubTator, text miningPubMed
Pathogenic Variants in PET Complex Encoding Genes TDRD12 and EXD1 Impair piRNA Biogenesis and Cause Male Infertility.Hum Mutat202642631111PubTator, text miningPubMed
Dysregulation of piRNA biogenesis-associated proteins in cancer: mechanisms, evidence, and translational constraints.Front Mol Biosci202642625859PubTator, text miningPubMed
PIWI-piRNA Axis in Epilepsy: Bridging Epigenetic Regulation, Neuroinflammation, and Neuronal Excitability.Mol Neurobiol202642572073PubTator, text miningPubMed
The emerging roles of small nucleolar RNAs, piwi-interacting RNAs, tRNA-derived small RNAs, and circular RNAs in the regulation of cardiac hypertrophy, ischemic heart disease, and heart failure.Genes Dis202642502482PubTator, text miningPubMed
Dibromoacetic acid impairs spermatogenesis: integrative evidence from human epidemiology, network toxicology, and mechanistic validation.Environ Int202642468183PubTator, text miningPubMed
Inverse co-variation of circulating PIWIL2 and PIWIL4 in gastric adenocarcinoma: an exploratory ELISA-based study.Clin Proteomics202642402549PubTator, text miningPubMed
piR-hsa-8111406 promotes proliferation and serves as a novel biomarker for early detection of ovarian cancer: a multi-center retrospective study.Int J Gynecol Cancer202642391800PubTator, text miningPubMed
piR-LGBM: A Sparse Autoencoder-Enhanced Gradient Boosting Framework to Uncover Disease-Associated piRNAs.OMICS202642267858PubTator, text miningPubMed
Landscape and biogenesis of piRNAs in HBV-associated hepatocarcinogenesis: from repetitive elements to oncogenic circuits.Discov Oncol202642258089PubTator, text miningPubMed

1 to 10 of 2,375

See all 2,375 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9271

GET https://conductscience.org/api/genes/v1/9271/patents?page=2