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MS4A1: membrane spanning 4-domains A1

1 protein, 667 patents, 18 drugs, 2,777 trials, 10,321 NIH grants and 18,262 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMS4A1HGNC
Namemembrane spanning 4-domains A1HGNC
NCBI Gene ID931NCBI Gene
HGNC IDHGNC:7315HGNC
EnsemblENSG00000156738NCBI Gene
AliasesB1, Bp35, CD20, CVID5, FMC7, LEU-16, S7NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P11836B-lymphocyte antigen CD2029710Ensembl, GeneID, HGNCUniProt

Patents 667

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4777551 A12026-07-225P11836Espacenet
EP 4754264 A12026-06-10573P11836Espacenet
JP 2026094130 A2026-06-0943P11836Espacenet
US 12643953 B22026-06-0259P11836Espacenet
JP 2026513993 A2026-05-0129P11836Espacenet
US 12600780 B22026-04-141369P11836Espacenet
US 12600781 B22026-04-14436P11836Espacenet
JP 2026054469 A2026-03-26370P11836Espacenet
US 12570755 B22026-03-1059P11836Espacenet
US 12565530 B22026-03-03159P11836Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EPCORITAMABCHEMBL4650393B-lymphocyte antigen CD20 binding agentBINDING AGENTChEMBL
FBT-A05CHEMBL2109351B-lymphocyte antigen CD20 cross-linking agentCROSS-LINKING AGENTChEMBL
GLOFITAMABCHEMBL4298092B-lymphocyte antigen CD20 binding agentBINDING AGENTChEMBL
LFB-R603CHEMBL2109348B-lymphocyte antigen CD20 binding agentBINDING AGENTChEMBL
MOSUNETUZUMABCHEMBL4297788B-lymphocyte antigen CD20 binding agentBINDING AGENTChEMBL
MT-3724CHEMBL4297789B-lymphocyte antigen CD20 binding agentBINDING AGENTChEMBL
OBINUTUZUMABCHEMBL1743048B-lymphocyte antigen CD20 binding agentBINDING AGENTChEMBL
OCARATUZUMABCHEMBL2109665B-lymphocyte antigen CD20 binding agentBINDING AGENTChEMBL
OCRELIZUMABCHEMBL2108041B-lymphocyte antigen CD20 binding agentBINDING AGENTChEMBL
ODRONEXTAMABCHEMBL4298084B-lymphocyte antigen CD20 binding agentBINDING AGENTChEMBL

Trials 2777

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07607197RITUXIMABPHASE1/PHASE2ClinicalTrials.gov
NCT07606521OCRELIZUMABPHASE1ClinicalTrials.gov
NCT07604987RITUXIMABPHASE2ClinicalTrials.gov
NCT07601607RITUXIMABPHASE1/PHASE2ClinicalTrials.gov
NCT07598396MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07597668OCRELIZUMABPHASE1ClinicalTrials.gov
NCT07588698RITUXIMABPHASE2ClinicalTrials.gov
NCT07588698EPCORITAMABPHASE2ClinicalTrials.gov
NCT07583810RITUXIMABPHASE2ClinicalTrials.gov
NCT07578077RITUXIMABPHASE1/PHASE2ClinicalTrials.gov

NIH grants 10321

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant962,025NIH's project files
P30CA008748Cancer Center Support Grant752,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award362,025NIH's project files
P30CA016042Cancer Center Support Grant272,025NIH's project files
R37AI054165Statistical Methods for Efficacy Trials of Vaccines and Monoclonal Antibodies Against Genetically-Diverse Pathogens232,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility202,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028172,025NIH's project files
R01NS073671Statistical Methods for Integrating Mixed-type Biomarkers and Phenotypes in Neurodegenerative Disease Modeling172,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program162,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support152,025NIH's project files

Papers 18262

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819571PubTator, text miningPubMed
42802798PubTator, text miningPubMed
42727219PubTator, text miningPubMed
42708818PubTator, text miningPubMed
42708731PubTator, text miningPubMed
42696602PubTator, text miningPubMed
42691815PubTator, text miningPubMed
42669051PubTator, text miningPubMed
42638932PubTator, text miningPubMed
42629974PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license