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KLF4: KLF transcription factor 4

1 protein, 38 patents, 0 drugs, 0 trials, 9,007 NIH grants and 17,889 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolKLF4HGNC
NameKLF transcription factor 4HGNC
NCBI Gene ID9314NCBI Gene
HGNC IDHGNC:6348HGNC
EnsemblENSG00000136826NCBI Gene
AliasesEZF, GKLFNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O43474Krueppel-like factor 45131Ensembl, GeneID, HGNCUniProt

Patents 38

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16624O43474Espacenet
WO 2026171881 A12026-08-205O43474Espacenet
JP 2026091847 A2026-06-042O43474Espacenet
JP 2026086827 A2026-05-266O43474Espacenet
EP 4650780 A22025-11-1946751O43474Espacenet
WO 2025235563 A12025-11-1326O43474Espacenet
JP 2025147176 A2025-10-0615218O43474Espacenet
JP 2025517970 A2025-06-1246751O43474Espacenet
EP 4553154 A12025-05-145O43474Espacenet
JP 2025507265 A2025-03-186O43474Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 9007

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant632,025NIH's project files
P30CA016672Cancer Center Support Grant502,025NIH's project files
R01DK052230Regulation of Intestinal Epithelial Cell Proliferation392,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award302,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)272,025NIH's project files
ZIATR000018Drug Repurposing Screening for Rare and Neglected Diseases212,025NIH's project files
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling202,025NIH's project files
ZICHL006145NHLBI iPSC Core Facility202,025NIH's project files
P30EY008098Core Grant for Vision Research192,025NIH's project files
P30DK050306Center for Molecular Studies in Digestive and Liver Diseases182,025NIH's project files

Papers 17889

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826207PubTator, text miningPubMed
42822446PubTator, text miningPubMed
42820305PubTator, text miningPubMed
42820287PubTator, text miningPubMed
42812056PubTator, text miningPubMed
42807844PubTator, text miningPubMed
42801360PubTator, text miningPubMed
42792910PubTator, text miningPubMed
42778761PubTator, text miningPubMed
42753072PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license