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Gene · 9353

SLIT2: slit guidance ligand 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLIT2: slit guidance ligand 2. Genes, record 9353. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9353

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Gene

Symbol
SLIT2
HGNC
Name
slit guidance ligand 2
HGNC
NCBI Gene ID
9353
NCBI Gene
HGNC ID
HGNC:11086
HGNC
Ensembl
ENSG00000145147
NCBI Gene
Aliases
SLIL3, Slit-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O94813Slit homolog 2 protein1,5294Ensembl, GeneID, HGNC

Source UniProt

Patents74

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1463722O94813Espacenet
EP 4650780 A22025-11-1914642O94813Espacenet
EP 4641201 A22025-10-2917202O94813Espacenet
JP 2025147176 A2025-10-0612489O94813Espacenet
JP 2025529142 A2025-09-044340O94813Espacenet
JP 2025529142 A2025-09-047747O94813Espacenet
US 12371689 B22025-07-294340O94813Espacenet
US 12371689 B22025-07-297747O94813Espacenet
JP 2025517969 A2025-06-1217202O94813Espacenet
JP 2025517970 A2025-06-1214642O94813Espacenet

1 to 10 of 74

See all 74 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,536

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLIT2 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)52025
P30CA006973Regional Oncology Research Center42025
P30CA008748Cancer Center Support Grant42025
P30CA016058Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
P30EY007003University of Michigan Vision Research Center42025
R01HL125811Slit2-ROBO signaling in pericytes and myeloid cells controls vascular development and ocular neovascular disease42025
T32CA009592Microenvironmental Influences in Cancer42025
K12CA090628Paul Calabresi Program in Clinical/Translational Research at Mayo Clinic32025
P20GM103440Nevada IDeA Networks of Biomedical Research Excellence (INBRE)32025

1 to 10 of 1,536Source NIH's project files

See all 1,536 nih grants

Papers2,094

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SLIT2 modulates leukaemic cell proliferation and stromal support in acute myeloid leukaemia models.Br J Haematol202642786580PubTator, text miningPubMed
Gbx2 and Robo receptors control amacrine cell dendrite stratification in the mammalian retina.Dev Biol202642716364PubTator, text miningPubMed
Druggable tumor-nerve-immune circuits in cancer pain: Model systems, human translatability and therapeutic paradoxes.Pharmacol Res202642716238PubTator, text miningPubMed
The nociceptor-CGRP-lactate axis in cancer immune escape: Linking neural signaling, immunometabolism, and immunotherapy resistance.Pharmacol Res202642702340PubTator, text miningPubMed
Exploring the protective potential of remote ischemic conditioning-induced miRNAs in stroke.Neuroscience202642603607PubTator, text miningPubMed
Impaired adipogenesis and lipid storage capacity in subcutaneous adipose tissue of patients with PMOS.JCI Insight202642579798PubTator, text miningPubMed
SLIT2 and ANGPTL3 as putative mediators linking obesity to atrial fibrillation: A Mendelian randomization study.Medicine (Baltimore)202642410793PubTator, text miningPubMed
SLIT-ROBO Signaling in Diabetes: A Dual Regulator of Angiogenesis and Vascular Dysfunction.Compr Physiol202642397141PubTator, text miningPubMed
A novel circSLIT2-encoded SLIT2 isoform suppresses neural invasion in gastric cancer.Oncogene202642362756PubTator, text miningPubMed
SLIT2 and ROBO-axis inhibitors for the treatment of cancer: a patent review (2020-2026).Expert Opin Ther Pat202642311159PubTator, text miningPubMed

1 to 10 of 2,094

See all 2,094 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9353

GET https://conductscience.org/api/genes/v1/9353/patents?page=2