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Gene · 9355

LHX2: LIM homeobox 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LHX2: LIM homeobox 2. Genes, record 9355. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9355

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Gene

Symbol
LHX2
HGNC
Name
LIM homeobox 2
HGNC
NCBI Gene ID
9355
NCBI Gene
HGNC ID
HGNC:6594
HGNC
Ensembl
ENSG00000106689
NCBI Gene
Aliases
LH-2, LH2, hLhx2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P50458LIM/homeobox protein Lhx24060Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1451765P50458Espacenet
EP 4641201 A22025-10-299584P50458Espacenet
JP 2025147176 A2025-10-0615239P50458Espacenet
JP 2025517969 A2025-06-129584P50458Espacenet
JP 2025028160 A2025-02-2815239P50458Espacenet
KR 1020250010750 A2025-01-2115239P50458Espacenet
JP 2024109657 A2024-08-1415078P50458Espacenet
US 11446398 B22022-09-2046808P50458Espacenet
JP 2022524081 A2022-04-27149779P50458Espacenet
JP 2021536249 A2021-12-2715432P50458Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,350

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLHX2 papersNewest fiscal year
R01AR050452Skin Stem Cells and Their Niche Interactions72025
R24HD000836Laboratory of Developmental Biology52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
P30CA062203Cancer Center Support Grant42025
P30CA008748Cancer Center Support Grant32025
P30CA016042Cancer Center Support Grant32025
P30EY001730Vision Research Core32025
P30EY014800University of Utah Core Vision Research Grant32025
P30EY022589NEI Center Core Grant for Vision Research32025
P50CA211015UCLA SPORE in Brain Cancer32025

1 to 10 of 1,350Source NIH's project files

See all 1,350 nih grants

Papers1,559

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transcriptome profiling of ocular surface ectoderm derived from embryonic stem cells, and identification of CACNG6 and AQP3 as its surface markers.Int J Ophthalmol202642523845PubTator, text miningPubMed
LHX2: a transcription factor in development, homeostasis, repair, and disease.Front Cell Dev Biol202642368448PubTator, text miningPubMed
Modeling Human Hypertrophic Scars with Induced Pluripotent Stem-Cell-Derived Scar Organoids Versus Skin Organoids.Cells202642274563PubTator, text miningPubMed
Temporal control of midline crossing via incoherent feedforward and feedback loops regulating Robo3.iScience202642181240PubTator, text miningPubMed
Quantitative coupling of clonal CNV evolution and spatially restricted malignant states identifies MFGE8 as a candidate late-state-associated target in breast cancer.J Transl Med202642169126PubTator, text miningPubMed
Screening and Application of Novel DNA Aptamers for Targeting Tilapia Lake Virus-Infected Cells.J Fish Dis202642057438PubTator, text miningPubMed
LHX2 is associated with tumor microenvironment characteristics in clear cell renal cell carcinoma and modulates the malignant phenotypes of cancer cells.Pathol Res Pract202641962205PubTator, text miningPubMed
Exploring Biological Quantum Effects in Photosynthesis across Varied Spatial Scales.J Phys Chem B202641920077PubTator, text miningPubMed
Establishing Area-Specific Brain Organoids Through Transcription Factor-Mediated Patterning.Biology (Basel)202641892247PubTator, text miningPubMed
Prediction of strong Cu(I)-He interaction at open metal sites enables isotope-selective helium adsorption.Nat Commun202641888520PubTator, text miningPubMed

1 to 10 of 1,559

See all 1,559 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9355

GET https://conductscience.org/api/genes/v1/9355/patents?page=2