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Gene · 9361

LONP1: lon peptidase 1, mitochondrial

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LONP1: lon peptidase 1, mitochondrial. Genes, record 9361. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9361

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Gene

Symbol
LONP1
HGNC
Name
lon peptidase 1, mitochondrial
HGNC
NCBI Gene ID
9361
NCBI Gene
HGNC ID
HGNC:9479
HGNC
Ensembl
ENSG00000196365
NCBI Gene
Aliases
CODASS, LON, LONP, LonHS, PIM1, PRSS15, hLON
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P36776Lon protease homolog, mitochondrial95931Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-197802P36776Espacenet
EP 4641201 A22025-10-297887P36776Espacenet
JP 2025517969 A2025-06-127887P36776Espacenet
JP 2025517970 A2025-06-127802P36776Espacenet
US 11564998 B22023-01-316019P36776Espacenet
US 11446398 B22022-09-2047134P36776Espacenet
JP 2022524081 A2022-04-27150105P36776Espacenet
WO 2020043864 A12020-03-051358P36776Espacenet
US 10463751 B22019-11-056019P36776Espacenet
JP 2018023373 A2018-02-1528746P36776Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,179

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLONP1 papersNewest fiscal year
T32AG052374USC-Buck Geroscience Training in the Biology of Aging122025
P40OD010440Caenorhabditis Genetics Center62025
R01NS095892IMPACTING MITOCHONDRIAL FUNCTION THROUGH ALTERED PROTEASE ACTIVITY62025
R35GM130320Regulated Proteolysis in Bacteria Development and Stress Response62025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025
P30CA010815Consolidated Basic Cancer Research Program42025
P30AG050886Comparative Bioenergetics of Aging32025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA062203Cancer Center Support Grant32025
P30ES007048Environmental Exposures, Host Factors and Human Disease32025

1 to 10 of 1,179Source NIH's project files

See all 1,179 nih grants

Papers1,777

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A selective inhibitor reveals roles for LONP1 in mitochondrial proteostasis and OXPHOS dependencies.Life Sci Alliance202642823380PubTator, text miningPubMed
The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1.Philos Trans R Soc Lond B Biol Sci202642817635PubTator, text miningPubMed
Transcriptional Regulation of Receptor-Mediated Mitophagy in Sunitinib-Resistant Renal Cancer Cells: Response to Succinic Acid.Pharmaceuticals (Basel)202642797377PubTator, text miningPubMed
Bardoxolone methyl induces mitochondrial dysfunction, activation of the cytosolic stress response, and increased chaperone capacity in SH-SY5Y cells. Focus on mitochondrial protease LONP1.Gen Physiol Biophys202642717783PubTator, text miningPubMed
Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase MTR activity.Proc Natl Acad Sci U S A202642709793PubTator, text miningPubMed
EPS8 Differentially Regulates Antioxidant Defense and Mitochondrial Homeostatic Signaling in LNCaP and Enzalutamide-resistant LNCaP Cells.Cancer Genomics Proteomics202642674824PubTator, text miningPubMed
Reprogramming Mitochondrial Adaptation: LONP1 at the Crossroads of Proteostasis, Metabolism, and Disease.Antioxidants (Basel)202642510524PubTator, text miningPubMed
Deciphering LonP1's role in glioblastoma: an alternative mechanism of treatment resistance.Am J Physiol Cell Physiol202642478633PubTator, text miningPubMed
Mitochondrial transcription factor A: linking mtDNA maintenance, mitochondrial stress responses, and inflammaging.Front Aging202642421742PubTator, text miningPubMed
The role of mitochondrial proteases in inflammation and immunity.Front Immunol202642416079PubTator, text miningPubMed

1 to 10 of 1,777

See all 1,777 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9361

GET https://conductscience.org/api/genes/v1/9361/patents?page=2