Gene · 9361
LONP1: lon peptidase 1, mitochondrial
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LONP1: lon peptidase 1, mitochondrial. Genes, record 9361. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9361
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P36776 | Lon protease homolog, mitochondrial | 959 | 31 | Ensembl, GeneID, HGNC |
Source UniProt
Patents43
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 7802 | P36776 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7887 | P36776 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7887 | P36776 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7802 | P36776 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 6019 | P36776 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 47134 | P36776 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 150105 | P36776 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 1358 | P36776 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 6019 | P36776 | Espacenet |
| JP 2018023373 A | 2018-02-15 | 28746 | P36776 | Espacenet |
1 to 10 of 43
See all 43 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,179
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LONP1 papers | Newest fiscal year |
|---|---|---|---|
| T32AG052374 | USC-Buck Geroscience Training in the Biology of Aging | 12 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 6 | 2025 |
| R01NS095892 | IMPACTING MITOCHONDRIAL FUNCTION THROUGH ALTERED PROTEASE ACTIVITY | 6 | 2025 |
| R35GM130320 | Regulated Proteolysis in Bacteria Development and Stress Response | 6 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 5 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 4 | 2025 |
| P30AG050886 | Comparative Bioenergetics of Aging | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 3 | 2025 |
| P30ES007048 | Environmental Exposures, Host Factors and Human Disease | 3 | 2025 |
1 to 10 of 1,179Source NIH's project files
See all 1,179 nih grantsPapers1,777
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A selective inhibitor reveals roles for LONP1 in mitochondrial proteostasis and OXPHOS dependencies. | Life Sci Alliance | 2026 | 42823380 | PubTator, text mining | PubMed |
| The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1. | Philos Trans R Soc Lond B Biol Sci | 2026 | 42817635 | PubTator, text mining | PubMed |
| Transcriptional Regulation of Receptor-Mediated Mitophagy in Sunitinib-Resistant Renal Cancer Cells: Response to Succinic Acid. | Pharmaceuticals (Basel) | 2026 | 42797377 | PubTator, text mining | PubMed |
| Bardoxolone methyl induces mitochondrial dysfunction, activation of the cytosolic stress response, and increased chaperone capacity in SH-SY5Y cells. Focus on mitochondrial protease LONP1. | Gen Physiol Biophys | 2026 | 42717783 | PubTator, text mining | PubMed |
| Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase MTR activity. | Proc Natl Acad Sci U S A | 2026 | 42709793 | PubTator, text mining | PubMed |
| EPS8 Differentially Regulates Antioxidant Defense and Mitochondrial Homeostatic Signaling in LNCaP and Enzalutamide-resistant LNCaP Cells. | Cancer Genomics Proteomics | 2026 | 42674824 | PubTator, text mining | PubMed |
| Reprogramming Mitochondrial Adaptation: LONP1 at the Crossroads of Proteostasis, Metabolism, and Disease. | Antioxidants (Basel) | 2026 | 42510524 | PubTator, text mining | PubMed |
| Deciphering LonP1's role in glioblastoma: an alternative mechanism of treatment resistance. | Am J Physiol Cell Physiol | 2026 | 42478633 | PubTator, text mining | PubMed |
| Mitochondrial transcription factor A: linking mtDNA maintenance, mitochondrial stress responses, and inflammaging. | Front Aging | 2026 | 42421742 | PubTator, text mining | PubMed |
| The role of mitochondrial proteases in inflammation and immunity. | Front Immunol | 2026 | 42416079 | PubTator, text mining | PubMed |
1 to 10 of 1,777
See all 1,777 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9361
GET https://conductscience.org/api/genes/v1/9361/patents?page=2