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KL: klotho

1 protein, 138 patents, 0 drugs, 0 trials, 2,971 NIH grants and 7,839 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolKLHGNC
NameklothoHGNC
NCBI Gene ID9365NCBI Gene
HGNC IDHGNC:6344HGNC
EnsemblENSG00000133116NCBI Gene
AliasesHFTC3, KLANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9UEF7Klotho1,0126Ensembl, GeneID, HGNCUniProt

Patents 138

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026511117 A2026-04-1049Q9UEF7Espacenet
WO 2025255508 A12025-12-112Q9UEF7Espacenet
EP 4650780 A22025-11-1910270Q9UEF7Espacenet
JP 2025169942 A2025-11-141117Q9UEF7Espacenet
EP 4641201 A22025-10-2910576Q9UEF7Espacenet
JP 2025529142 A2025-09-042309Q9UEF7Espacenet
US 12371689 B22025-07-292309Q9UEF7Espacenet
JP 2025090742 A2025-06-171Q9UEF7Espacenet
JP 2025517969 A2025-06-1210576Q9UEF7Espacenet
JP 2025517970 A2025-06-1210270Q9UEF7Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2971

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant192,025NIH's project files
P30CA016672Cancer Center Support Grant112,025NIH's project files
ZIADE000649Skeletal Disorders and Mineral Homeostasis Section82,025NIH's project files
P30AG062715Wisconsin Alzheimer's Disease Research Center72,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant72,025NIH's project files
U01DK060902Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center72,025NIH's project files
U01DK060963Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study72,025NIH's project files
U01DK060980Continuation of the University of Illinois Chicago CRIC Clinical Center72,025NIH's project files
U01DK060984Prospective renal insufficiency cohort evaluation: PRICE72,025NIH's project files
U01DK061021Chronic Renal Insufficiency Cohort Limited competition continuation72,025NIH's project files

Papers 7839

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821452PubTator, text miningPubMed
42816442PubTator, text miningPubMed
42797299PubTator, text miningPubMed
42794753PubTator, text miningPubMed
42793073PubTator, text miningPubMed
42792767PubTator, text miningPubMed
42788794PubTator, text miningPubMed
42787856PubTator, text miningPubMed
42781617PubTator, text miningPubMed
42774539PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license