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Gene · 9368

NHERF1: NHERF family PDZ scaffold protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NHERF1: NHERF family PDZ scaffold protein 1. Genes, record 9368. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9368

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Gene

Symbol
NHERF1
HGNC
Name
NHERF family PDZ scaffold protein 1
HGNC
NCBI Gene ID
9368
NCBI Gene
HGNC ID
HGNC:11075
HGNC
Ensembl
ENSG00000109062
NCBI Gene
Aliases
EBP50, NHE-RF, NHERF, NHERF-1, NPHLOP2, SLC9A3R1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14745Na(+)/H(+) exchange regulatory cofactor NHE-RF135822Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1464869O14745Espacenet
EP 4650780 A22025-11-192098O14745Espacenet
JP 2025537282 A2025-11-142O14745Espacenet
EP 4641201 A22025-10-291659O14745Espacenet
EP 4615418 A12025-09-172O14745Espacenet
JP 2025517969 A2025-06-121659O14745Espacenet
JP 2025517970 A2025-06-122098O14745Espacenet
EP 4484957 A12025-01-01126O14745Espacenet
WO 2023162878 A2023-08-31126O14745Espacenet
US 11676731 B22023-06-1342O14745Espacenet

1 to 10 of 60

See all 60 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,269

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNHERF1 papersNewest fiscal year
R01DK080834Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea112025
P30CA016672Cancer Center Support Grant102025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)52025
P30DK034989Yale Liver Center42025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis42025
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA021765Cancer Center Support Grant (CCSG)32025
P30CA068485Cancer Center Support Grant32025

1 to 10 of 1,269Source NIH's project files

See all 1,269 nih grants

Papers1,739

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Regulation of CFTR stability at the plasma membrane-Mechanisms and therapeutic opportunities in cystic fibrosis.FEBS Lett202642403151PubTator, text miningPubMed
NHE1-Mediated Metabolic Reprogramming in Cancer.Metabolites202641893344PubTator, text miningPubMed
The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets.Cells202641892342PubTator, text miningPubMed
Molecular Switching from Morule to Squamous Metaplasia via p40 and the EBP50/S100A4/Myosin 9 Axis in Endometrial Carcinoma.Am J Pathol202641881309PubTator, text miningPubMed
On the mechanism of ezrin activation.Biophys J202641852029PubTator, text miningPubMed
A Novel SLC9A3R1 Mutation as a Rare Cause of Infantile Hypercalcemia.Cureus202641798566PubTator, text miningPubMed
Molecular mechanisms in podocytopathies: finding suitable targets for a new era of glomerular gene therapy.Clin Kidney J202641788620PubTator, text miningPubMed
Identifying of Ubiquitin-Fold Modifier 1 as a Potential Prognostic Biomarker for Unresectable Pancreatic Cancer by Proteomics Analysis.Cancer Manag Res202641767421PubTator, text miningPubMed
Deep biochemical phenotyping reveals prognostic value of rare genetic variants in adult kidney stone disease.J Clin Invest202641766659PubTator, text miningPubMed
GPCR-Mediated Cell Intelligence: A Potential Mechanism for Survival and Long-Term Health.Curr Issues Mol Biol202641751391PubTator, text miningPubMed

1 to 10 of 1,739

See all 1,739 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9368

GET https://conductscience.org/api/genes/v1/9368/patents?page=2