Gene · 9368
NHERF1: NHERF family PDZ scaffold protein 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NHERF1: NHERF family PDZ scaffold protein 1. Genes, record 9368. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9368
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14745 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 | 358 | 22 | Ensembl, GeneID, HGNC |
Source UniProt
Patents60
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 64869 | O14745 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2098 | O14745 | Espacenet |
| JP 2025537282 A | 2025-11-14 | 2 | O14745 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1659 | O14745 | Espacenet |
| EP 4615418 A1 | 2025-09-17 | 2 | O14745 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1659 | O14745 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2098 | O14745 | Espacenet |
| EP 4484957 A1 | 2025-01-01 | 126 | O14745 | Espacenet |
| WO 2023162878 A | 2023-08-31 | 126 | O14745 | Espacenet |
| US 11676731 B2 | 2023-06-13 | 42 | O14745 | Espacenet |
1 to 10 of 60
See all 60 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,269
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NHERF1 papers | Newest fiscal year |
|---|---|---|---|
| R01DK080834 | Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30ES017885 | Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) | 5 | 2025 |
| P30DK034989 | Yale Liver Center | 4 | 2025 |
| R01DA012864 | Mechanisms and Cellular Function of Opioid Receptor Endocytosis | 4 | 2025 |
| R01HL016037 | Molecular Regulation of Cardiovascular 7 TM Receptors | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,269Source NIH's project files
See all 1,269 nih grantsPapers1,739
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Regulation of CFTR stability at the plasma membrane-Mechanisms and therapeutic opportunities in cystic fibrosis. | FEBS Lett | 2026 | 42403151 | PubTator, text mining | PubMed |
| NHE1-Mediated Metabolic Reprogramming in Cancer. | Metabolites | 2026 | 41893344 | PubTator, text mining | PubMed |
| The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets. | Cells | 2026 | 41892342 | PubTator, text mining | PubMed |
| Molecular Switching from Morule to Squamous Metaplasia via p40 and the EBP50/S100A4/Myosin 9 Axis in Endometrial Carcinoma. | Am J Pathol | 2026 | 41881309 | PubTator, text mining | PubMed |
| On the mechanism of ezrin activation. | Biophys J | 2026 | 41852029 | PubTator, text mining | PubMed |
| A Novel SLC9A3R1 Mutation as a Rare Cause of Infantile Hypercalcemia. | Cureus | 2026 | 41798566 | PubTator, text mining | PubMed |
| Molecular mechanisms in podocytopathies: finding suitable targets for a new era of glomerular gene therapy. | Clin Kidney J | 2026 | 41788620 | PubTator, text mining | PubMed |
| Identifying of Ubiquitin-Fold Modifier 1 as a Potential Prognostic Biomarker for Unresectable Pancreatic Cancer by Proteomics Analysis. | Cancer Manag Res | 2026 | 41767421 | PubTator, text mining | PubMed |
| Deep biochemical phenotyping reveals prognostic value of rare genetic variants in adult kidney stone disease. | J Clin Invest | 2026 | 41766659 | PubTator, text mining | PubMed |
| GPCR-Mediated Cell Intelligence: A Potential Mechanism for Survival and Long-Term Health. | Curr Issues Mol Biol | 2026 | 41751391 | PubTator, text mining | PubMed |
1 to 10 of 1,739
See all 1,739 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9368
GET https://conductscience.org/api/genes/v1/9368/patents?page=2