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Gene · 9378

NRXN1: neurexin 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NRXN1: neurexin 1. Genes, record 9378. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9378

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Gene

Symbol
NRXN1
HGNC
Name
neurexin 1
HGNC
NCBI Gene ID
9378
NCBI Gene
HGNC ID
HGNC:8008
HGNC
Ensembl
ENSG00000179915
NCBI Gene
Aliases
Hs.22998, KIAA0578, PTHSL2, SCZD17
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins2

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P58400Neurexin-1-beta4722Ensembl, GeneID, HGNCUniProt
Q9ULB1Neurexin-11,4771Ensembl, GeneID, HGNCUniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12636345 B22026-05-2614P58400Espacenet
US 12636345 B22026-05-2616Q9ULB1Espacenet
JP 2026004568 A2026-01-1455304Q9ULB1Espacenet
EP 4650780 A22025-11-1911800Q9ULB1Espacenet
EP 4641201 A22025-10-2912550Q9ULB1Espacenet
EP 4641201 A22025-10-2912782P58400Espacenet
JP 2025147176 A2025-10-069559Q9ULB1Espacenet
JP 2025147176 A2025-10-069573P58400Espacenet
JP 2025529142 A2025-09-042912Q9ULB1Espacenet
JP 2025529142 A2025-09-047182Q9ULB1Espacenet

1 to 10 of 61

See all 61 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,307

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNRXN1 papersNewest fiscal year
R25MH077823Research Education for Future Physician-Scientists in Child Psychiatry92025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)72025
R01MH101221Rare Mutations and Autism Spectrum Disorders62025
UL1TR001863Yale Clinical and Translational Science Award62025
R01MH074090Gene Dosage Imbalance in Neurodevelopmental Disorders52025
P30ES010126UNC Center for Environmental Health and Susceptibility42025
P30ES013508Center of Excellence in Environmental Toxicology42025
R01HD081256Clinical Diagnostic Sequencing of Structural Variation42025
R01MH077303Synaptic Organizers: Dynamic Regulation of Trans-synaptic Bridges42025
T32HG000035Interdisciplinary Training in Genome Sciences42025

1 to 10 of 2,307Source NIH's project files

See all 2,307 nih grants

Papers2,134

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Neurexin mediates neuropeptide release from cholinergic motor neurons through dense-core vesicle localization.bioRxiv202642818522PubTator, text miningPubMed
Chromosomal Microarray Diagnostic Yield and Copy Number Variants in a Clinically Well-Characterized Cohort with Nonsyndromic Autism Spectrum Disorder from Southern Brazil.Diagnostics (Basel)202642793732PubTator, text miningPubMed
In vivo dissection of human NRXN1 isoforms reveals gain-of-function pathogenicity of schizophrenia-associated 3' deletions.Hum Mol Genet202642696786PubTator, text miningPubMed
Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis.Science202642691176PubTator, text miningPubMed
Prenatal diagnosis of a familial 2p16.3 deletion encompassing NRXN1 associated with no apparently phenotypic abnormality in the family carrier members.Taiwan J Obstet Gynecol202642642129PubTator, text miningPubMed
Pleiotrophin regulates presynaptic assembly and function through heparan sulfate-dependent binding to neurexin1.Cell Rep202642585021PubTator, text miningPubMed
Clinical Phenotypes Associated with NRXN1 Deletions in Five Children with Autism Spectrum Disorder in Oman.Sultan Qaboos Univ Med J202642549207PubTator, text miningPubMed
Intrafamilial Variability in NRXN1-Associated Neurodevelopmental Disorders: Clinical and Genetic Insights from a Family Case Study with Literature Review.Int J Mol Sci202642511584PubTator, text miningPubMed
Genome-Wide and Rare Variant Association Studies of Amblyopia in Admixed American and African Ancestry Groups.Ophthalmology202642508771PubTator, text miningPubMed
G-protein coupled receptor, signal and signal-transduction related transcript mapping in nigral volume and pigmented neurons reveals a potential deficit of nigral feedback signals associated with Parkinson's disease.
PLoS One202642497285PubTator, text miningPubMed

1 to 10 of 2,134

See all 2,134 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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