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Gene · 94

ACVRL1: activin A receptor like type 1

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. ACVRL1: activin A receptor like type 1. Genes, record 94. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/94

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
ACVRL1
HGNC
Name
activin A receptor like type 1
HGNC
NCBI Gene ID
94
NCBI Gene
HGNC ID
HGNC:175
HGNC
Ensembl
ENSG00000139567
NCBI Gene
Aliases
ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P37023Activin receptor type-1-like5037Ensembl, GeneID, HGNC

Source UniProt

Patents101

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026027383 A2026-02-1830P37023Espacenet
JP 2026004568 A2026-01-1436220P37023Espacenet
JP 2026004568 A2026-01-1436221P37023Espacenet
EP 4650780 A22025-11-1910645P37023Espacenet
JP 2025147176 A2025-10-06206P37023Espacenet
US 12421295 B22025-09-2314P37023Espacenet
JP 2025529142 A2025-09-04260P37023Espacenet
JP 2025529142 A2025-09-045365P37023Espacenet
US 12371689 B22025-07-29260P37023Espacenet
US 12371689 B22025-07-295365P37023Espacenet

1 to 10 of 101

See all 101 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ASCRINVACUMABCHEMBL2109295Serine/threonine-protein kinase receptor R3 inhibitorINHIBITORChEMBL
PANULISIBCHEMBL5095025Serine/threonine-protein kinase receptor R3 inhibitorINHIBITORChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05178043ASCRINVACUMABPHASE2ClinicalTrials.gov
NCT04984668ASCRINVACUMABPHASE1/PHASE2ClinicalTrials.gov
NCT03893695ASCRINVACUMABPHASE1/PHASE2ClinicalTrials.gov
NCT02116894ASCRINVACUMABPHASE1ClinicalTrials.gov
NCT01911273ASCRINVACUMABPHASE22015-06-29ClinicalTrials.gov
NCT01486368ASCRINVACUMABPHASE2ClinicalTrials.gov
NCT00557856ASCRINVACUMABPHASE12015-08-13ClinicalTrials.gov

NIH grants1,737

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA008748Cancer Center Support Grant222025
P30CA016672Cancer Center Support Grant172025
R01HL081397Mechanism of Matrix Gla Protein (MGP); Adipose Fibrosis82025
R01HL125811Slit2-ROBO signaling in pericytes and myeloid cells controls vascular development and ocular neovascular disease72025
T32GM008440Comprehensive Anesthesia Research Training72025
UL1TR001863Yale Clinical and Translational Science Award72025
P30CA054174Mays Cancer Center at UT Health SA62025
R01HL076246Chemokines in healing myocardial infarction52025
R01HL085440Resolution of inflammation in healing myocardial infarcts52025
ZIABC011070Hematopathology Diagnosis52025

1 to 10 of 1,737Source NIH's project files

See all 1,737 nih grants

Papers4,014

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42793006PubTator, text miningPubMed
42784888PubTator, text miningPubMed
42778431PubTator, text miningPubMed
42776922PubTator, text miningPubMed
42723961PubTator, text miningPubMed
42721788PubTator, text miningPubMed
42705706PubTator, text miningPubMed
42666972PubTator, text miningPubMed
42644811PubTator, text miningPubMed
42621902PubTator, text miningPubMed

1 to 10 of 4,014

See all 4,014 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/94

GET https://conductscience.org/api/genes/v1/94/patents?page=2