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Gene · 9401

RECQL4: RecQ like helicase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. RECQL4: RecQ like helicase 4. Genes, record 9401. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9401

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Gene

Symbol
RECQL4
HGNC
Name
RecQ like helicase 4
HGNC
NCBI Gene ID
9401
NCBI Gene
HGNC ID
HGNC:9949
HGNC
Ensembl
ENSG00000160957
NCBI Gene
Aliases
RECQ4, RecQ4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O94761ATP-dependent DNA helicase Q41,2082Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2923272O94761Espacenet
EP 4641202 A22025-10-299510O94761Espacenet
JP 2025517969 A2025-06-1223272O94761Espacenet
KR 1020250017231 A2025-02-049510O94761Espacenet
EP 4464338 A22024-11-20178O94761Espacenet
EP 4464338 A22024-11-20365O94761Espacenet
US 11834686 B22023-12-0562O94761Espacenet
US 11680268 B22023-06-20178O94761Espacenet
US 11680268 B22023-06-20365O94761Espacenet
US 11597924 B22023-03-0748O94761Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants825

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRECQL4 papersNewest fiscal year
ZIAAG000726Function of RecQ helicases in genome stability402025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability312025
P30CA008748Cancer Center Support Grant182025
ZIAAG000753Fanconi Anemia Pathway172025
ZIAAG000752Model Genetic Systems to Study DNA Repair162025
P01CA092584Structural Cell Biology of DNA Repair Machines102025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant52025
R01ES007061Mechanisms of DNA Double-strand Break End Resection and Repair Pathway Choice52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025

1 to 10 of 825Source NIH's project files

See all 825 nih grants

Papers1,646

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DNA binding contributes to dominant-negative effects of a catalytically inactive RecQ4-family helicase.Nucleic Acids Res202642755368PubTator, text miningPubMed
MCM10 and RECQL4 have cooperative and redundant roles in activating the CMG helicase during the replication initiation.Genes Dev202642697600PubTator, text miningPubMed
Retraction Note: TRIM58 functions as a tumor suppressor in colorectal cancer by promoting RECQL4 ubiquitination to inhibit the AKT signaling pathway.World J Surg Oncol202642649497PubTator, text miningPubMed
Identification of a Pathogenic RECQL4 1.6-kb Deletion-Insertion in a Neonate with Atypical Skeletal Phenotype of Baller-Gerold Syndrome Using Rapid Whole-Genome Sequencing.Ann Lab Med202642608969PubTator, text miningPubMed
Distinct Mitochondrial Central Dogma Gene Expression in the Buffalo Brain: A Comparative Transcriptomic Study with Metabolically Active Organs.Mol Neurobiol202642606642PubTator, text miningPubMed
[WRN and Other RecQ Helicases in Life Cycles of Viruses].Mol Biol (Mosk)202642599232PubTator, text miningPubMed
Integrative Network-Based Transcriptomic Analysis Identifies Niclosamide as a Candidate Repositioned Drug for Breast Cancer.Breast Cancer (Dove Med Press)202642524299PubTator, text miningPubMed
RECQ4 arginine methylation suppresses single-stranded DNA gap accumulation at replication forks.Nucleic Acids Res202642363758PubTator, text miningPubMed
Case Report: A case of Rothmund-Thomson syndrome-like phenotype with an ANAPC1 variant of uncertain significance and observed hair improvement.Front Med (Lausanne)202642210937PubTator, text miningPubMed
A novel mitochondrial-related signature to decode tumor immunity and predict survival in chromophobe renal cell carcinoma.Immunobiology202642155297PubTator, text miningPubMed

1 to 10 of 1,646

See all 1,646 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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