Gene · 9401
RECQL4: RecQ like helicase 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. RECQL4: RecQ like helicase 4. Genes, record 9401. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9401
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O94761 | ATP-dependent DNA helicase Q4 | 1,208 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4641201 A2 | 2025-10-29 | 23272 | O94761 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 9510 | O94761 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 23272 | O94761 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 9510 | O94761 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 178 | O94761 | Espacenet |
| EP 4464338 A2 | 2024-11-20 | 365 | O94761 | Espacenet |
| US 11834686 B2 | 2023-12-05 | 62 | O94761 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 178 | O94761 | Espacenet |
| US 11680268 B2 | 2023-06-20 | 365 | O94761 | Espacenet |
| US 11597924 B2 | 2023-03-07 | 48 | O94761 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants825
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | RECQL4 papers | Newest fiscal year |
|---|---|---|---|
| ZIAAG000726 | Function of RecQ helicases in genome stability | 40 | 2025 |
| ZIAAG000741 | Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability | 31 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 18 | 2025 |
| ZIAAG000753 | Fanconi Anemia Pathway | 17 | 2025 |
| ZIAAG000752 | Model Genetic Systems to Study DNA Repair | 16 | 2025 |
| P01CA092584 | Structural Cell Biology of DNA Repair Machines | 10 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| R01ES007061 | Mechanisms of DNA Double-strand Break End Resection and Repair Pathway Choice | 5 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 4 | 2025 |
1 to 10 of 825Source NIH's project files
See all 825 nih grantsPapers1,646
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| DNA binding contributes to dominant-negative effects of a catalytically inactive RecQ4-family helicase. | Nucleic Acids Res | 2026 | 42755368 | PubTator, text mining | PubMed |
| MCM10 and RECQL4 have cooperative and redundant roles in activating the CMG helicase during the replication initiation. | Genes Dev | 2026 | 42697600 | PubTator, text mining | PubMed |
| Retraction Note: TRIM58 functions as a tumor suppressor in colorectal cancer by promoting RECQL4 ubiquitination to inhibit the AKT signaling pathway. | World J Surg Oncol | 2026 | 42649497 | PubTator, text mining | PubMed |
| Identification of a Pathogenic RECQL4 1.6-kb Deletion-Insertion in a Neonate with Atypical Skeletal Phenotype of Baller-Gerold Syndrome Using Rapid Whole-Genome Sequencing. | Ann Lab Med | 2026 | 42608969 | PubTator, text mining | PubMed |
| Distinct Mitochondrial Central Dogma Gene Expression in the Buffalo Brain: A Comparative Transcriptomic Study with Metabolically Active Organs. | Mol Neurobiol | 2026 | 42606642 | PubTator, text mining | PubMed |
| [WRN and Other RecQ Helicases in Life Cycles of Viruses]. | Mol Biol (Mosk) | 2026 | 42599232 | PubTator, text mining | PubMed |
| Integrative Network-Based Transcriptomic Analysis Identifies Niclosamide as a Candidate Repositioned Drug for Breast Cancer. | Breast Cancer (Dove Med Press) | 2026 | 42524299 | PubTator, text mining | PubMed |
| RECQ4 arginine methylation suppresses single-stranded DNA gap accumulation at replication forks. | Nucleic Acids Res | 2026 | 42363758 | PubTator, text mining | PubMed |
| Case Report: A case of Rothmund-Thomson syndrome-like phenotype with an ANAPC1 variant of uncertain significance and observed hair improvement. | Front Med (Lausanne) | 2026 | 42210937 | PubTator, text mining | PubMed |
| A novel mitochondrial-related signature to decode tumor immunity and predict survival in chromophobe renal cell carcinoma. | Immunobiology | 2026 | 42155297 | PubTator, text mining | PubMed |
1 to 10 of 1,646
See all 1,646 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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The record and each of its lists are JSON, twenty rows a page. No key.
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