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MUC16: mucin 16, cell surface associated

1 protein, 124 patents, 4 drugs, 17 trials, 3,928 NIH grants and 30,566 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMUC16HGNC
Namemucin 16, cell surface associatedHGNC
NCBI Gene ID94025NCBI Gene
HGNC IDHGNC:15582HGNC
EnsemblENSG00000181143NCBI Gene
AliasesCA-125, CA125, FLJ14303NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q8WXI7Mucin-1614,5074Ensembl, GeneID, HGNCUniProt

Patents 124

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026217896 A12026-10-15125Q8WXI7Espacenet
US 12570764 B22026-03-101899Q8WXI7Espacenet
EP 4684803 A12026-01-2813Q8WXI7Espacenet
JP 2026004432 A2026-01-1453Q8WXI7Espacenet
US 12514926 B22026-01-0653Q8WXI7Espacenet
EP 4640698 A22025-10-291Q8WXI7Espacenet
EP 4641201 A22025-10-2912101Q8WXI7Espacenet
JP 2025147176 A2025-10-0614696Q8WXI7Espacenet
JP 2025093943 A2025-06-24148Q8WXI7Espacenet
JP 2025517969 A2025-06-1212101Q8WXI7Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABAGOVOMABCHEMBL1742981Mucin-16 otherOTHERChEMBL
IGOVOMABCHEMBL2109036Mucin-16 binding agentBINDING AGENTChEMBL
OREGOVOMABCHEMBL2107917Mucin-16 otherOTHERChEMBL
SOFITUZUMAB VEDOTINCHEMBL3545372Mucin-16 binding agentBINDING AGENTChEMBL

Trials 17

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05605535OREGOVOMABPHASE2ClinicalTrials.gov
NCT05407584OREGOVOMABPHASE2ClinicalTrials.gov
NCT05335993OREGOVOMABPHASE2ClinicalTrials.gov
NCT04938583OREGOVOMABPHASE1/PHASE2ClinicalTrials.gov
NCT04498117OREGOVOMABPHASE3ClinicalTrials.gov
NCT03162562OREGOVOMABPHASE1ClinicalTrials.gov
NCT03100006OREGOVOMABPHASE1/PHASE2ClinicalTrials.gov
NCT01959672OREGOVOMABPHASE22019-11-15ClinicalTrials.gov
NCT01616303OREGOVOMABPHASE2ClinicalTrials.gov
NCT01335958SOFITUZUMAB VEDOTINPHASE1ClinicalTrials.gov

NIH grants 3928

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2082,025NIH's project files
P30CA016672Cancer Center Support Grant2032,025NIH's project files
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer542,025NIH's project files
T32CA101642Training of Academic Gynecologic Oncologists442,025NIH's project files
P30CA006973Regional Oncology Research Center432,025NIH's project files
U10CA180822NRG Oncology - Statistical and Data Management Center402,025NIH's project files
U10CA180868NRG Oncology Network Group Operations Center382,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant342,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant302,025NIH's project files
U01CA200466Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma252,025NIH's project files

Papers 30566

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42821018PubTator, text miningPubMed
42813863PubTator, text miningPubMed
42811502PubTator, text miningPubMed
42805118PubTator, text miningPubMed
42804995PubTator, text miningPubMed
42804924PubTator, text miningPubMed
42802860PubTator, text miningPubMed
42802476PubTator, text miningPubMed
42798321PubTator, text miningPubMed
42795931PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license