Gene · 9414
TJP2: tight junction protein 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TJP2: tight junction protein 2. Genes, record 9414. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9414
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UDY2 | Tight junction protein 2 | 1,190 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 83 | Q9UDY2 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 67138 | Q9UDY2 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9896 | Q9UDY2 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10160 | Q9UDY2 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5672 | Q9UDY2 | Espacenet |
| WO 2025212858 A1 | 2025-10-09 | 2 | Q9UDY2 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10160 | Q9UDY2 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9896 | Q9UDY2 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5672 | Q9UDY2 | Espacenet |
| JP 2024522861 A | 2024-06-21 | 46 | Q9UDY2 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,387
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TJP2 papers | Newest fiscal year |
|---|---|---|---|
| R01DK061931 | Mechanisms and pathophysiologic impact of claudin-2 modulation | 10 | 2025 |
| R01DK068271 | Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease. | 10 | 2025 |
| R01MH072567 | HIV-1 and amyloid beta interactions at the blood-brain barrier | 8 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 5 | 2025 |
| P30DK034989 | Yale Liver Center | 5 | 2025 |
| P30DK078392 | Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease | 5 | 2025 |
| R01DK079392 | Intestinal Inflammation: Signaling proteins and the rate of PMN transmigration | 5 | 2025 |
| U01DK062453 | Colorado Center of Childhood Liver Disease ResearchNetwork | 5 | 2025 |
| P30DK042086 | Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID) | 4 | 2025 |
| R35GM118096 | Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesis | 4 | 2025 |
1 to 10 of 1,387Source NIH's project files
See all 1,387 nih grantsPapers2,301
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| ZO-2 blocks the localization of PGAM5 protein to the mitochondrial membrane and suppresses pancreatic cancer malignancy through metabolic reprogramming. | Genes Dis | 2027 | 42763477 | PubTator, text mining | PubMed |
| Membrane Raft Redox Signaling Mediates Trimethylamine N-Oxide-Induced NLRP3 Inflammasome Activation and Endothelial Dysfunction. | Antioxidants (Basel) | 2026 | 42792177 | PubTator, text mining | PubMed |
| Trio-Based Whole-Exome Sequencing Identifies Convergent Epithelial Junction-Related Pathways in Syndromic Hidradenitis Suppurativa. | Dermatology | 2026 | 42709635 | PubTator, text mining | PubMed |
| Use of Next-Generation Sequencing and Whole-Exome Sequencing in the Diagnosis of Adult-Onset Familial Intrahepatic Cholestasis: Challenges in Interpreting Variants of Uncertain Significance. | Diagnostics (Basel) | 2026 | 42587573 | PubTator, text mining | PubMed |
| Transcriptome-Wide Cox Regression Identifies Candidate Survival-Associated Genes in Newly Diagnosed Acute Myeloid Leukemia. | Cancer Inform | 2026 | 42572530 | PubTator, text mining | PubMed |
| Genotype-Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study. | Am J Med Genet A | 2026 | 42477309 | PubTator, text mining | PubMed |
| 12-HHT is associated with epithelial barrier enhancement and reduced inflammatory responses in colon organoids of normoganglionosis in Hirschsprung's disease. | PLoS One | 2026 | 42461884 | PubTator, text mining | PubMed |
| Porcine epidemic diarrhea virus influences the expression of tight junction proteins through the polarity protein PAR6. | Virus Genes | 2026 | 42423934 | PubTator, text mining | PubMed |
| A direct interaction of JAM-C with the tight junction scaffold protein ZO-2. | Sci Rep | 2026 | 42270729 | PubTator, text mining | PubMed |
| CLIC1 acts as a compensatory protective molecule to regulate the vascular endothelial barrier integrity in cutaneous inflammation. | Clin Immunol | 2026 | 42184897 | PubTator, text mining | PubMed |
1 to 10 of 2,301
See all 2,301 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9414
GET https://conductscience.org/api/genes/v1/9414/patents?page=2