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Gene · 9414

TJP2: tight junction protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TJP2: tight junction protein 2. Genes, record 9414. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9414

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Gene

Symbol
TJP2
HGNC
Name
tight junction protein 2
HGNC
NCBI Gene ID
9414
NCBI Gene
HGNC ID
HGNC:11828
HGNC
Ensembl
ENSG00000119139
NCBI Gene
Aliases
C9DUPq21.11, DFNA51, DUP9q21.11, FHCA1, PFIC4, X104, ZO-2, ZO2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UDY2Tight junction protein 21,1902Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-2183Q9UDY2Espacenet
JP 2026004568 A2026-01-1467138Q9UDY2Espacenet
EP 4650780 A22025-11-199896Q9UDY2Espacenet
EP 4641201 A22025-10-2910160Q9UDY2Espacenet
EP 4641202 A22025-10-295672Q9UDY2Espacenet
WO 2025212858 A12025-10-092Q9UDY2Espacenet
JP 2025517969 A2025-06-1210160Q9UDY2Espacenet
JP 2025517970 A2025-06-129896Q9UDY2Espacenet
KR 1020250017231 A2025-02-045672Q9UDY2Espacenet
JP 2024522861 A2024-06-2146Q9UDY2Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,387

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTJP2 papersNewest fiscal year
R01DK061931Mechanisms and pathophysiologic impact of claudin-2 modulation102025
R01DK068271Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.102025
R01MH072567HIV-1 and amyloid beta interactions at the blood-brain barrier82025
P30CA068485Cancer Center Support Grant52025
P30DK034989Yale Liver Center52025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease52025
R01DK079392Intestinal Inflammation: Signaling proteins and the rate of PMN transmigration52025
U01DK062453Colorado Center of Childhood Liver Disease ResearchNetwork52025
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)42025
R35GM118096Regulating cell fate and shaping the body plan during morphogenesis and their alteration during oncogenesis42025

1 to 10 of 1,387Source NIH's project files

See all 1,387 nih grants

Papers2,301

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ZO-2 blocks the localization of PGAM5 protein to the mitochondrial membrane and suppresses pancreatic cancer malignancy through metabolic reprogramming.Genes Dis202742763477PubTator, text miningPubMed
Membrane Raft Redox Signaling Mediates Trimethylamine N-Oxide-Induced NLRP3 Inflammasome Activation and Endothelial Dysfunction.Antioxidants (Basel)202642792177PubTator, text miningPubMed
Trio-Based Whole-Exome Sequencing Identifies Convergent Epithelial Junction-Related Pathways in Syndromic Hidradenitis Suppurativa.Dermatology202642709635PubTator, text miningPubMed
Use of Next-Generation Sequencing and Whole-Exome Sequencing in the Diagnosis of Adult-Onset Familial Intrahepatic Cholestasis: Challenges in Interpreting Variants of Uncertain Significance.Diagnostics (Basel)202642587573PubTator, text miningPubMed
Transcriptome-Wide Cox Regression Identifies Candidate Survival-Associated Genes in Newly Diagnosed Acute Myeloid Leukemia.Cancer Inform202642572530PubTator, text miningPubMed
Genotype-Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study.Am J Med Genet A202642477309PubTator, text miningPubMed
12-HHT is associated with epithelial barrier enhancement and reduced inflammatory responses in colon organoids of normoganglionosis in Hirschsprung's disease.PLoS One202642461884PubTator, text miningPubMed
Porcine epidemic diarrhea virus influences the expression of tight junction proteins through the polarity protein PAR6.Virus Genes202642423934PubTator, text miningPubMed
A direct interaction of JAM-C with the tight junction scaffold protein ZO-2.Sci Rep202642270729PubTator, text miningPubMed
CLIC1 acts as a compensatory protective molecule to regulate the vascular endothelial barrier integrity in cutaneous inflammation.Clin Immunol202642184897PubTator, text miningPubMed

1 to 10 of 2,301

See all 2,301 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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