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Gene · 94233

OPN4: opsin 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OPN4: opsin 4. Genes, record 94233. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/94233

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Gene

Symbol
OPN4
HGNC
Name
opsin 4
HGNC
NCBI Gene ID
94233
NCBI Gene
HGNC ID
HGNC:14449
HGNC
Ensembl
ENSG00000122375
NCBI Gene
Aliases
MOP, melanopsin
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UHM6Melanopsin4780Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025529142 A2025-09-042948Q9UHM6Espacenet
US 12371689 B22025-07-292948Q9UHM6Espacenet
JP 2025519378 A2025-06-261Q9UHM6Espacenet
US 11446398 B22022-09-2060187Q9UHM6Espacenet
US 11400116 B22022-08-025480Q9UHM6Espacenet
JP 2022524081 A2022-04-27163158Q9UHM6Espacenet
US 10292374 B22019-05-21682Q9UHM6Espacenet
EP 3318285 A12018-05-093Q9UHM6Espacenet
JP 2017121240 A2017-07-1352738Q9UHM6Espacenet
JP 2015518704 A2015-07-0652738Q9UHM6Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,166

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOPN4 papersNewest fiscal year
P30EY001730Vision Research Core282025
P30EY001792P30 Core Grant for Vision Research202025
P30EY001583P30 Core Grant For Vision Research182025
R01EY014596Melanopsin Photoreception and Signaling172025
P30EY003039UAB Core Grant for Vision Research152025
T32HL007901Training in Sleep, Circadian, and Respiratory Neurobiology142025
P30EY007003University of Michigan Vision Research Center122025
ZIAMH002964Section on Light and Circadian Rhythms102025
P30EY006360P30-Core Grant for Vision Research92025
T32EY007031Vision Training Grant92025

1 to 10 of 1,166Source NIH's project files

See all 1,166 nih grants

Papers2,377

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Divergence of Melanopsin's Intrinsic Properties and Downstream Actions.bioRxiv202642779720PubTator, text miningPubMed
Binocular combination in the autonomic nervous system.PLoS One202642679018PubTator, text miningPubMed
Melanopsin gene polymorphism and volumetric change in the left hippocampal dentate gyrus following light therapy in mood disorders: An exploratory study.Front Psychiatry202642661861PubTator, text miningPubMed
The Dark Side of Light: Spectral Variation in Post-Traumatic Photosensitivity and Its Functional Sequelae.Brain Sci202642651148PubTator, text miningPubMed
Annual Solar Cycles: Investigating Seasonal Variations in Southern Norway and Their Potential Role in Human Eye Growth.Invest Ophthalmol Vis Sci202642627119PubTator, text miningPubMed
Photoreceptor-specific scene statistics reveal melanopic structure in natural environments.iScience202642620723PubTator, text miningPubMed
Multimodal circadian phenotyping reveals distinct mechanisms of photic entrainment failure in two sighted patients with non-24-hour sleep-wake disorder.Sleep Med202642612567PubTator, text miningPubMed
A systematic review and narrative synthesis of functional neuroimaging studies for chronic ocular surface pain.Surv Ophthalmol202642586445PubTator, text miningPubMed
Circadian Regulation of Glucose Metabolism: Implications for Pathogenesis and Chronotherapy of Type 2 Diabetes.Diabetology (Basel)202642583078PubTator, text miningPubMed
Impact of Human Melanopsin Gene (OPN4) Polymorphisms (I394T, P10L) on Nocturnal Melatonin and Daily Rhythms in Young Adults.J Pineal Res202642578404PubTator, text miningPubMed

1 to 10 of 2,377

See all 2,377 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/94233

GET https://conductscience.org/api/genes/v1/94233/patents