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TNFRSF8: TNF receptor superfamily member 8

1 protein, 257 patents, 4 drugs, 179 trials, 8,449 NIH grants and 25,287 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTNFRSF8HGNC
NameTNF receptor superfamily member 8HGNC
NCBI Gene ID943NCBI Gene
HGNC IDHGNC:11923HGNC
EnsemblENSG00000120949NCBI Gene
AliasesCD30, D1S166E, KI-1, Ki-1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P28908Tumor necrosis factor receptor superfamily member 85951Ensembl, GeneID, HGNCUniProt

Patents 257

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12600781 B22026-04-14472P28908Espacenet
EP 4705273 A22026-03-11317P28908Espacenet
WO 2026019692 A22026-01-2232P28908Espacenet
JP 2026500100 A2026-01-062054P28908Espacenet
WO 2025245111 A12025-11-272P28908Espacenet
JP 2025172069 A2025-11-20695P28908Espacenet
EP 4650780 A22025-11-192273P28908Espacenet
EP 4640849 A22025-10-29269P28908Espacenet
EP 4641201 A22025-10-291842P28908Espacenet
EP 4641202 A22025-10-29112P28908Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BRENTUXIMAB VEDOTINCHEMBL1742994Tumor necrosis factor receptor superfamily member 8 binding agentBINDING AGENTChEMBL
HEFI-1CHEMBL2109255Tumor necrosis factor receptor superfamily member 8 binding agentBINDING AGENTChEMBL
IRATUMUMABCHEMBL2108612Tumor necrosis factor receptor superfamily member 8 otherOTHERChEMBL
SGN-30CHEMBL2109256Tumor necrosis factor receptor superfamily member 8 agonistAGONISTChEMBL

Trials 179

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07572123BRENTUXIMAB VEDOTINPHASE2/PHASE3ClinicalTrials.gov
NCT07275216BRENTUXIMAB VEDOTINPHASE2ClinicalTrials.gov
NCT07258680BRENTUXIMAB VEDOTINPHASE3ClinicalTrials.gov
NCT07171827BRENTUXIMAB VEDOTINClinicalTrials.gov
NCT07145125BRENTUXIMAB VEDOTINClinicalTrials.gov
NCT07074457BRENTUXIMAB VEDOTINClinicalTrials.gov
NCT07013565BRENTUXIMAB VEDOTINPHASE2ClinicalTrials.gov
NCT07002216BRENTUXIMAB VEDOTINPHASE2ClinicalTrials.gov
NCT06925555BRENTUXIMAB VEDOTINPHASE2ClinicalTrials.gov
NCT06563245BRENTUXIMAB VEDOTINPHASE2/PHASE3ClinicalTrials.gov

NIH grants 8449

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1732,025NIH's project files
P30CA016672Cancer Center Support Grant1082,025NIH's project files
ZIASC000550Lymphoma Disease Discovery and Definition532,025NIH's project files
ZIABC011070Hematopathology Diagnosis482,025NIH's project files
P50CA126752SPORE in Lymphoma462,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award412,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)302,025NIH's project files
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant272,025NIH's project files
ZIEBC011241Hematopathology Fellowship262,025NIH's project files
P30CA006973Regional Oncology Research Center232,025NIH's project files

Papers 25287

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826002PubTator, text miningPubMed
42816478PubTator, text miningPubMed
42813170PubTator, text miningPubMed
42801263PubTator, text miningPubMed
42799861PubTator, text miningPubMed
42778210PubTator, text miningPubMed
42776063PubTator, text miningPubMed
42757708PubTator, text miningPubMed
42750965PubTator, text miningPubMed
42746506PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license