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Gene · 9448

MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. Genes, record 9448. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9448

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Gene

Symbol
MAP4K4
HGNC
Name
mitogen-activated protein kinase kinase kinase kinase 4
HGNC
NCBI Gene ID
9448
NCBI Gene
HGNC ID
HGNC:6866
HGNC
Ensembl
ENSG00000071054
NCBI Gene
Aliases
FLH21957, HEL-S-31, HGK, MEKKK4, NIK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95819Mitogen-activated protein kinase kinase kinase kinase 41,23919Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12558356 B22026-02-2411O95819Espacenet
EP 4650780 A22025-11-194953O95819Espacenet
EP 4641201 A22025-10-294529O95819Espacenet
JP 2025517969 A2025-06-124529O95819Espacenet
JP 2025517970 A2025-06-124953O95819Espacenet
US 11564998 B22023-01-315809O95819Espacenet
US 11446398 B22022-09-2052626O95819Espacenet
JP 2022524081 A2022-04-27155597O95819Espacenet
US 11078247 B22021-08-036561O95819Espacenet
US 10463751 B22019-11-055809O95819Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,280

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAP4K4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
R35NS116846Design of Precision Small Molecules Targeting RNA Repeating Transcripts to Manipulate and Study Disease Biology62025
R01GM126048Regulation and function of the Hippo pathway in growth control42025
T32ES018827Research Training in Environmental Toxicology42025
UL1TR001863Yale Clinical and Translational Science Award42025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology32025
P30CA008748Cancer Center Support Grant32025
P30CA062203Cancer Center Support Grant32025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement32025
U10CA180899Children's Oncology Group Statistics and Data Center32025

1 to 10 of 1,280Source NIH's project files

See all 1,280 nih grants

Papers1,615

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A multistage computational pipeline integrating ligand-based and structure-based screening with ADMET evaluation, molecular dynamic simulation and free energy calculations for the discovery of potential TNIK inhibitors.
Talanta202742485955PubTator, text miningPubMed
Methodological Pitfalls in Endometriosis Biospecimen Research: Lessons From MAP4K4 Expression Studies.FASEB Bioadv202642769725PubTator, text miningPubMed
Identification of ultrasound-associated gene candidates in myeloid cells and construction of a prognostic risk model for acute myeloid leukemia.PeerJ202642729953PubTator, text miningPubMed
Design, synthesis, and biological evaluation of novel 1-aryl-3-hydroxypyrrolidine derivatives as dual HGK/HPK1 inhibitors with therapeutic potential for lung cancer.Bioorg Chem202642721525PubTator, text miningPubMed
Phosphatidylserine-based liposomes encapsulating DMX-5804 protect against doxorubicin-induced cardiotoxicity.RSC Pharm202642719253PubTator, text miningPubMed
Targeting MAPK Pathways in Skin, Thyroid, and Pancreatic Cancer: A Perspective on Synthetic Inhibitors and Natural Modulators.Adv Biol (Weinh)202642708305PubTator, text miningPubMed
KLF4/MLL3 complex axis drives NRBP2 transcription to eliminate acute myeloid leukemia cells.Leukemia202642686832PubTator, text miningPubMed
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circ Res202642594169PubTator, text miningPubMed
De Novo Discovery of Nonstandard Thioisoindole-Bridged Bicyclic Peptides Targeting Traf2- and NCK-Interacting Kinase.Angew Chem Int Ed Engl202642593841PubTator, text miningPubMed
Splicing factor HNRNPD and alternative splicing of MAP4K4 are associated with cell apoptosis and immune microenvironment features in Wilms' tumor.PLoS One202642560952PubTator, text miningPubMed

1 to 10 of 1,615

See all 1,615 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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