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EIF2AK3: eukaryotic translation initiation factor 2 alpha kinase 3

1 protein, 24 patents, 0 drugs, 0 trials, 9,838 NIH grants and 19,069 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolEIF2AK3HGNC
Nameeukaryotic translation initiation factor 2 alpha kinase 3HGNC
NCBI Gene ID9451NCBI Gene
HGNC IDHGNC:3255HGNC
EnsemblENSG00000172071NCBI Gene
AliasesPEK, PERK, WRSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9NZJ5Eukaryotic translation initiation factor 2-alpha kinase 31,11615Ensembl, GeneID, HGNCUniProt

Patents 24

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1445466Q9NZJ5Espacenet
EP 4650780 A22025-11-194482Q9NZJ5Espacenet
EP 4641201 A22025-10-294025Q9NZJ5Espacenet
JP 2025529142 A2025-09-041368Q9NZJ5Espacenet
JP 2025121934 A2025-08-2012Q9NZJ5Espacenet
US 12371689 B22025-07-291368Q9NZJ5Espacenet
JP 2025517969 A2025-06-124025Q9NZJ5Espacenet
JP 2025517970 A2025-06-124482Q9NZJ5Espacenet
JP 2025032204 A2025-03-1127709Q9NZJ5Espacenet
EP 4461818 A22024-11-1327709Q9NZJ5Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 9838

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1602,025NIH's project files
P30CA008748Cancer Center Support Grant1122,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant432,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program372,025NIH's project files
P30CA016058Cancer Center Support Grant362,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant342,025NIH's project files
P30CA047904Cancer Center Support Grant332,025NIH's project files
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant252,025NIH's project files
P30CA006973Regional Oncology Research Center232,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)232,025NIH's project files

Papers 19069

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825516PubTator, text miningPubMed
42825362PubTator, text miningPubMed
42822072PubTator, text miningPubMed
42816207PubTator, text miningPubMed
42813994PubTator, text miningPubMed
42811839PubTator, text miningPubMed
42802286PubTator, text miningPubMed
42800448PubTator, text miningPubMed
42799139PubTator, text miningPubMed
42794732PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license