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Gene · 9464

HAND2: heart and neural crest derivatives expressed 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HAND2: heart and neural crest derivatives expressed 2. Genes, record 9464. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9464

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Gene

Symbol
HAND2
HGNC
Name
heart and neural crest derivatives expressed 2
HGNC
NCBI Gene ID
9464
NCBI Gene
HGNC ID
HGNC:4808
HGNC
Ensembl
ENSG00000164107
NCBI Gene
Aliases
DHAND2, Hed, Thing2, bHLHa26, dHand
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P61296Heart- and neural crest derivatives-expressed protein 22170Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448705P61296Espacenet
EP 4650780 A22025-11-197680P61296Espacenet
JP 2025147176 A2025-10-0615064P61296Espacenet
JP 2025517970 A2025-06-127680P61296Espacenet
JP 2025028160 A2025-02-2815064P61296Espacenet
KR 1020250010750 A2025-01-2115064P61296Espacenet
JP 2024109657 A2024-08-1414903P61296Espacenet
US 12024722 B22024-07-02260P61296Espacenet
US 11446398 B22022-09-2037248P61296Espacenet
JP 2022524081 A2022-04-27140219P61296Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,355

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHAND2 papersNewest fiscal year
R01HL057181Cardiogenesis: Molecular Mechanisms102025
P30CA021765Cancer Center Support Grant (CCSG)82025
P01HL134599Morphogenesis and growth of the ventricular wall in development and disease72025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling72025
P30CA008748Cancer Center Support Grant62025
T32ES007326Interdisciplinary Research Training Program in Environmental Health and Toxicology62025
P30CA016672Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
R35CA220500Discovering mechanisms of neuroblastoma tumorigenesis to improve patient outcomes42025
UL1TR001863Yale Clinical and Translational Science Award42025

1 to 10 of 1,355Source NIH's project files

See all 1,355 nih grants

Papers1,885

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic loci responsible for atrioventricular block in children.Front Cell Dev Biol202642798645PubTator, text miningPubMed
ERBB2 establishes the timing of progesterone priming required for uterine receptivity.bioRxiv202642779670PubTator, text miningPubMed
Exercise-induced cardiac hypertrophy: cellular and molecular mechanisms of cardiac adaptation following physical activity.Postepy Kardiol Interwencyjnej202642598495PubTator, text miningPubMed
Integrated Methylation and Copy Number Analysis for Noninvasive Bladder Cancer Detection in Urine.JCO Precis Oncol202642585615PubTator, text miningPubMed
Machine learning and single-cell RNA sequencing identify shared diagnostic genes and mechanistic links between antiphospholipid syndrome and carotid atherosclerosis.PeerJ202642569390PubTator, text miningPubMed
Association of Endometrial HAND2 Expression with β2-Glycoprotein I Antibodies in Recurrent Pregnancy Loss.Biomedicines202642512033PubTator, text miningPubMed
New Neuroendocrine Markers PITX2, PHOX2B, and HAND2 Do Not Offer Diagnostic Utility in Fine-needle Aspiration Biopsies of Primary and Secondary Medullary Thyroid Carcinomas: A Retrospective Multi-institutional Study.
J Clin Transl Pathol202642433465PubTator, text miningPubMed
Bclaf1 drives heart failure by recruiting Srsf2 to enhance Hand2 pre-mRNA splicing and pathological hypertrophy.Nat Commun202642409820PubTator, text miningPubMed
Integrative Observational and Genetic Evidence From the UK Biobank Supports Carotid Intima-Media Thickness as a Window Into Cardiac Remodeling.J Am Heart Assoc202642396779PubTator, text miningPubMed
Rare Truncating HAND2 Variants Predispose to Atrial Fibrillation.Genes (Basel)202642353861PubTator, text miningPubMed

1 to 10 of 1,885

See all 1,885 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9464

GET https://conductscience.org/api/genes/v1/9464/patents?page=2