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Gene · 9475

ROCK2: Rho associated coiled-coil containing protein kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ROCK2: Rho associated coiled-coil containing protein kinase 2. Genes, record 9475. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9475

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Gene

Symbol
ROCK2
HGNC
Name
Rho associated coiled-coil containing protein kinase 2
HGNC
NCBI Gene ID
9475
NCBI Gene
HGNC ID
HGNC:10252
HGNC
Ensembl
ENSG00000134318
NCBI Gene
Aliases
ROCK-II
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75116Rho-associated protein kinase 21,38823Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461828O75116Espacenet
EP 4650780 A22025-11-195147O75116Espacenet
EP 4641201 A22025-10-294745O75116Espacenet
JP 2025517969 A2025-06-124745O75116Espacenet
JP 2025517970 A2025-06-125147O75116Espacenet
EP 4491229 A22025-01-15233O75116Espacenet
WO 2024230934 A12024-11-14358O75116Espacenet
JP 2024510010 A2024-03-05219O75116Espacenet
US 11920164 B22024-03-0551O75116Espacenet
WO 2022195543 A2022-09-22219O75116Espacenet

1 to 10 of 48

See all 48 patents

Drugs15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMA0076CHEMBL3545073Rho-associated protein kinase inhibitorINHIBITORChEMBL
AT-13148CHEMBL3544960Rho-associated protein kinase inhibitorINHIBITORChEMBL
BELUMOSUDILCHEMBL2005186Rho-associated protein kinase 2 inhibitorINHIBITORChEMBL
BELUMOSUDILCHEMBL2005186Rho-associated protein kinase inhibitorINHIBITORChEMBL
BELUMOSUDIL MESYLATECHEMBL4802130Rho-associated protein kinase inhibitorINHIBITORChEMBL
DE-104CHEMBL3545153Rho-associated protein kinase inhibitorINHIBITORChEMBL
FASUDILCHEMBL38380Rho-associated protein kinase inhibitorINHIBITORChEMBL
NETARSUDILCHEMBL4594250Rho-associated protein kinase inhibitorINHIBITORChEMBL
NETARSUDIL DIMESYLATECHEMBL4594251Rho-associated protein kinase inhibitorINHIBITORChEMBL
RIPASUDILCHEMBL3426621Rho-associated protein kinase inhibitorINHIBITORChEMBL

1 to 10 of 15

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Trials87

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07588152NETARSUDILPHASE4ClinicalTrials.gov
NCT07484113BELUMOSUDILPHASE1ClinicalTrials.gov
NCT07325240NETARSUDILPHASE4ClinicalTrials.gov
NCT07135973BELUMOSUDILPHASE4ClinicalTrials.gov
NCT07116031BELUMOSUDILPHASE2ClinicalTrials.gov
NCT07082816NETARSUDILPHASE3ClinicalTrials.gov
NCT07048886NETARSUDILPHASE4ClinicalTrials.gov
NCT06969586NETARSUDILClinicalTrials.gov
NCT06960629NETARSUDILPHASE2/PHASE3ClinicalTrials.gov
NCT06883123NETARSUDIL DIMESYLATEPHASE4ClinicalTrials.gov

1 to 10 of 87

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NIH grants1,972

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleROCK2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant112025
P30CA076292Moffitt Cancer Center Support Grant92025
R01AG061800Identifying therapeutic targets that confer synaptic resilience to Alzheimer's disease82025
R01HL118979Enhancing Treg Therapeutic Efficacy in GVHD72025
T32NS061788UAB Research Training Program in Neurobiology of Cognition and Cognitive Disorders72025
P30CA056036Translational Research in Cancer62025
P01HL158505Mechanisms and Therapy of Chronic Graft-vs.-Host Disease52025
P30CA016672Cancer Center Support Grant52025
R37AI034495In Vivo Prevention of Murine GVHD52025
UL1TR001863Yale Clinical and Translational Science Award52025

1 to 10 of 1,972Source NIH's project files

See all 1,972 nih grants

Papers3,801

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Bacopa monnieri attenuates Alzheimer's pathology by modulating RNA metabolism, cellular stress responses, and Rho GTPase signaling: Phosphoproteomic insights from a cellular model of Alzheimer's disease.
Neurochem Int202642810623PubTator, text miningPubMed
Phosphoproteomic Data Integration Reveals Paralog-Specific Co-Regulatory Networks of Rho-Associated Kinases ROCK1 and ROCK2.Int J Mol Sci202642794553PubTator, text miningPubMed
RhoA in postnatal spinal motoneuron is essential for peripheral myelination.Commun Biol202642760283PubTator, text miningPubMed
Neuroinflammation in postoperative cognitive dysfunction: the multi-target potential of esketamine in modulating microglial responses and synaptic integrity.Front Mol Neurosci202642751135PubTator, text miningPubMed
Safety and Efficacy of Belumosudil for Steroid-Resistant Chronic-Graft-Versus-Host Disease: A Systematic Review.Indian J Hematol Blood Transfus202642712726PubTator, text miningPubMed
From metabolic antagonism to homeostatic restoration: rewiring hepatic stellate cell bioenergetics for liver fibrosis reversal.Front Med (Lausanne)202642708043PubTator, text miningPubMed
Canonical and non-canonical STAT3 pathways in epilepsy: Mechanistic insights and translational challenges.Life Sci202642679992PubTator, text miningPubMed
Belumosudil Demonstrates Steroid-Sparing, Safety, and Efficacy in Pediatric Chronic Graft-Versus-Host Disease.Transplant Cell Ther202642665020PubTator, text miningPubMed
[Retracted] miR-185-5p targets ROCK2 and inhibits cell migration and invasion of hepatocellular carcinoma.Oncol Lett202642639424PubTator, text miningPubMed
Structure-based discovery of novel ROCK2 inhibitors using integrated virtual screening, molecular dynamics, metadynamics and absolute binding free energy calculations.In Silico Pharmacol202642614366PubTator, text miningPubMed

1 to 10 of 3,801

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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