Gene · 9507
ADAMTS4: ADAM metallopeptidase with thrombospondin type 1 motif 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ADAMTS4: ADAM metallopeptidase with thrombospondin type 1 motif 4. Genes, record 9507. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9507
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O75173 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | 837 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 36461 | O75173 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8341 | O75173 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8529 | O75173 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 282 | O75173 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 282 | O75173 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8529 | O75173 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8341 | O75173 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 2305 | O75173 | Espacenet |
| US 11701379 B2 | 2023-07-18 | 11 | O75173 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 2305 | O75173 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,059
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ADAMTS4 papers | Newest fiscal year |
|---|---|---|---|
| P30EY010572 | Ophthalmology Core Facility | 16 | 2025 |
| R01EY019643 | Extracellular Matrix and Outflow Resistance | 10 | 2025 |
| P30AG028716 | Duke Claude D. Pepper Older Americans Independence Center | 4 | 2025 |
| P30AG024827 | Pittsburgh Older Americans Independence Center | 3 | 2025 |
| P30AR073752 | Washington University Rheumatic Diseases Research Resource-based Center | 3 | 2025 |
| P30AR074992 | RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE | 3 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 3 | 2025 |
| R01AR060364 | Molecular Pathways of Pain Generation in Osteoarthritis | 3 | 2025 |
| R01HL092577 | IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL | 3 | 2025 |
| T32AR060719 | Skeletal Disorders Training Program | 3 | 2025 |
1 to 10 of 1,059Source NIH's project files
See all 1,059 nih grantsPapers2,479
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Comprehensive analysis of global histone modification pattern with clinical features and therapeutic potential in glioma. | Cancer Treat Res Commun | 2026 | 42705046 | PubTator, text mining | PubMed |
| Deciphering osteoarthritis cartilage heterogeneity: gene expression-guided patient stratification and microbiome correlations. | Front Microbiol | 2026 | 42639051 | PubTator, text mining | PubMed |
| ADAMTS4 is a serum biomarker for pulmonary arterial hypertension associated with congenital heart disease. | Front Med (Lausanne) | 2026 | 42558857 | PubTator, text mining | PubMed |
| Integrated bioinformatics and experimental validation reveal that kaempferol ameliorates intervertebral disc degeneration via dual anti-inflammatory and anti-aging pathways. | Naunyn Schmiedebergs Arch Pharmacol | 2026 | 42525295 | PubTator, text mining | PubMed |
| Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation. | J Arrhythm | 2026 | 42491663 | PubTator, text mining | PubMed |
| GPx6 downregulation drives ferroptosis in Kashin-Beck disease chondrocytes via the SLC7A11/GPx4 axis. | Apoptosis | 2026 | 42384133 | PubTator, text mining | PubMed |
| Proteomic profiling of whole tissue sections in cardiac ATTR amyloidosis reveals increased extracellular matrix remodeling. | Cardiovasc Pathol | 2026 | 42303193 | PubTator, text mining | PubMed |
| Host transcriptional signatures associated with microbial sequence signals reveal age-related decline in intestinal homeostasis. | Future Microbiol | 2026 | 42227074 | PubTator, text mining | PubMed |
| Dihydroxyacetone nanoparticles ameliorate osteoarthritis via P21-mediated regulation of chondrocyte repair. | J Nanobiotechnology | 2026 | 42192449 | PubTator, text mining | PubMed |
| Synovial Fluid Proteomic Biomarkers in Knee Osteoarthritis: A Systematic Review and Gene Ontology Analysis. | Cartilage | 2026 | 42129958 | PubTator, text mining | PubMed |
1 to 10 of 2,479
See all 2,479 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9507
GET https://conductscience.org/api/genes/v1/9507/patents?page=2