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Gene · 9507

ADAMTS4: ADAM metallopeptidase with thrombospondin type 1 motif 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADAMTS4: ADAM metallopeptidase with thrombospondin type 1 motif 4. Genes, record 9507. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9507

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Gene

Symbol
ADAMTS4
HGNC
Name
ADAM metallopeptidase with thrombospondin type 1 motif 4
HGNC
NCBI Gene ID
9507
NCBI Gene
HGNC ID
HGNC:220
HGNC
Ensembl
ENSG00000158859
NCBI Gene
Aliases
ADAMTS-2, ADAMTS-4, ADMP-1, KIAA0688
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75173A disintegrin and metalloproteinase with thrombospondin motifs 48375Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436461O75173Espacenet
EP 4650780 A22025-11-198341O75173Espacenet
EP 4641201 A22025-10-298529O75173Espacenet
JP 2025529142 A2025-09-04282O75173Espacenet
US 12371689 B22025-07-29282O75173Espacenet
JP 2025517969 A2025-06-128529O75173Espacenet
JP 2025517970 A2025-06-128341O75173Espacenet
JP 2025062604 A2025-04-142305O75173Espacenet
US 11701379 B22023-07-1811O75173Espacenet
US 11446398 B22022-09-202305O75173Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,059

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADAMTS4 papersNewest fiscal year
P30EY010572Ophthalmology Core Facility162025
R01EY019643Extracellular Matrix and Outflow Resistance102025
P30AG028716Duke Claude D. Pepper Older Americans Independence Center42025
P30AG024827Pittsburgh Older Americans Independence Center32025
P30AR073752Washington University Rheumatic Diseases Research Resource-based Center32025
P30AR074992RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE32025
P30EY008126Core Grant in Vision Research32025
R01AR060364Molecular Pathways of Pain Generation in Osteoarthritis32025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL32025
T32AR060719Skeletal Disorders Training Program32025

1 to 10 of 1,059Source NIH's project files

See all 1,059 nih grants

Papers2,479

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Comprehensive analysis of global histone modification pattern with clinical features and therapeutic potential in glioma.Cancer Treat Res Commun202642705046PubTator, text miningPubMed
Deciphering osteoarthritis cartilage heterogeneity: gene expression-guided patient stratification and microbiome correlations.Front Microbiol202642639051PubTator, text miningPubMed
ADAMTS4 is a serum biomarker for pulmonary arterial hypertension associated with congenital heart disease.Front Med (Lausanne)202642558857PubTator, text miningPubMed
Integrated bioinformatics and experimental validation reveal that kaempferol ameliorates intervertebral disc degeneration via dual anti-inflammatory and anti-aging pathways.Naunyn Schmiedebergs Arch Pharmacol202642525295PubTator, text miningPubMed
Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation.J Arrhythm202642491663PubTator, text miningPubMed
GPx6 downregulation drives ferroptosis in Kashin-Beck disease chondrocytes via the SLC7A11/GPx4 axis.Apoptosis202642384133PubTator, text miningPubMed
Proteomic profiling of whole tissue sections in cardiac ATTR amyloidosis reveals increased extracellular matrix remodeling.Cardiovasc Pathol202642303193PubTator, text miningPubMed
Host transcriptional signatures associated with microbial sequence signals reveal age-related decline in intestinal homeostasis.Future Microbiol202642227074PubTator, text miningPubMed
Dihydroxyacetone nanoparticles ameliorate osteoarthritis via P21-mediated regulation of chondrocyte repair.J Nanobiotechnology202642192449PubTator, text miningPubMed
Synovial Fluid Proteomic Biomarkers in Knee Osteoarthritis: A Systematic Review and Gene Ontology Analysis.Cartilage202642129958PubTator, text miningPubMed

1 to 10 of 2,479

See all 2,479 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9507

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