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Gene · 9509

ADAMTS2: ADAM metallopeptidase with thrombospondin type 1 motif 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADAMTS2: ADAM metallopeptidase with thrombospondin type 1 motif 2. Genes, record 9509. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9509

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Gene

Symbol
ADAMTS2
HGNC
Name
ADAM metallopeptidase with thrombospondin type 1 motif 2
HGNC
NCBI Gene ID
9509
NCBI Gene
HGNC ID
HGNC:218
HGNC
Ensembl
ENSG00000087116
NCBI Gene
Aliases
ADAM-TS2, ADAMTS-2, ADAMTS-3, EDSDERMS, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI, hPCPNI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95450A disintegrin and metalloproteinase with thrombospondin motifs 21,2110Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436453O95450Espacenet
EP 4650780 A22025-11-191351O95450Espacenet
EP 4641201 A22025-10-29976O95450Espacenet
JP 2025147176 A2025-10-06353O95450Espacenet
JP 2025529142 A2025-09-045392O95450Espacenet
US 12371689 B22025-07-295392O95450Espacenet
JP 2025517969 A2025-06-12976O95450Espacenet
JP 2025517970 A2025-06-121351O95450Espacenet
JP 2025062604 A2025-04-142296O95450Espacenet
JP 2025032204 A2025-03-1124058O95450Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants802

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADAMTS2 papersNewest fiscal year
P30AG066507Johns Hopkins Alzheimer's Disease Research Center22025
P30AI050409Center for AIDS Research at Emory University22025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment22025
P30EY010572Ophthalmology Core Facility22025
P51OD011092Support for National Primate Research Center22025
P51OD011132Emory National Primate Research Center22025
R01DK117850Systems Genetics Dissection of Non-alcoholic Steatohepatitis22025
T32AR060719Skeletal Disorders Training Program22025
T32GM008243UCLA Medical Genetics Training Program22025
UL1TR001881UCLA Clinical and Translational Science Institute22025

1 to 10 of 802Source NIH's project files

See all 802 nih grants

Papers1,327

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative Multi-Omics and Machine Learning Reveal Senescent Fibroblast-Associated ADAMTS2 as a Critical Indicator of Intestinal Inflammation in IBD.FASEB J202642773852PubTator, text miningPubMed
RNAemia and Severe COVID-19: Candidate Treatment Targets Identified Through Transcriptomics.J Infect Dis202642525560PubTator, text miningPubMed
Greenspace Exposure and DNA Methylation Age Acceleration: A Systematic Review and Molecular Pathway Analysis.Int J Mol Sci202642511878PubTator, text miningPubMed
Transcriptome-wide m6A Methylation Profiling Reveals Regulatory Networks During Endothelial Differentiation of Bone Marrow Mesenchymal Stem Cells.Clin Appl Thromb Hemost202642501017PubTator, text miningPubMed
Consensus-based detection of aetiologic copy number variants for syndromic orofacial clefts utilising whole exome sequencing of case parent trios.BMC Genom Data202642420839PubTator, text miningPubMed
Distinct Molecular Signature of Earlobe Keloids: Integrated Transcriptomic Analysis of Extracellualr Matrix, Metalloproteinase, and Metabolic Pathways.Aesthetic Plast Surg202642414644PubTator, text miningPubMed
Exploring the Hemorrhagic Manifestations of an Adolescent With Dermatosparaxis-Type Ehlers-Danlos Syndrome: A Case Report.Cureus202642261541PubTator, text miningPubMed
Hypoxia reprograms VEGF signaling to differentially control ADAMTS2 and ADAMTS3 expression in endothelial cells.Tissue Cell202642224870PubTator, text miningPubMed
ADAMTS2 drives prostate cancer progression by activating FAK/PI3K/AKT signaling and suppressing ferroptosis via COL1A1.Front Oncol202642125710PubTator, text miningPubMed
ADAMTS2 Modulates Inflammation, Autophagy, and Barrier Integrity Through PI3K/AKT/mTOR Signaling in LPS-Induced Acute Respiratory Distress Syndrome.Immun Inflamm Dis202642011035PubTator, text miningPubMed

1 to 10 of 1,327

See all 1,327 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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