Gene · 9509
ADAMTS2: ADAM metallopeptidase with thrombospondin type 1 motif 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ADAMTS2: ADAM metallopeptidase with thrombospondin type 1 motif 2. Genes, record 9509. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9509
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95450 | A disintegrin and metalloproteinase with thrombospondin motifs 2 | 1,211 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents36
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 36453 | O95450 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1351 | O95450 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 976 | O95450 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 353 | O95450 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5392 | O95450 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5392 | O95450 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 976 | O95450 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1351 | O95450 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 2296 | O95450 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24058 | O95450 | Espacenet |
1 to 10 of 36
See all 36 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants802
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ADAMTS2 papers | Newest fiscal year |
|---|---|---|---|
| P30AG066507 | Johns Hopkins Alzheimer's Disease Research Center | 2 | 2025 |
| P30AI050409 | Center for AIDS Research at Emory University | 2 | 2025 |
| P30ES007033 | University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment | 2 | 2025 |
| P30EY010572 | Ophthalmology Core Facility | 2 | 2025 |
| P51OD011092 | Support for National Primate Research Center | 2 | 2025 |
| P51OD011132 | Emory National Primate Research Center | 2 | 2025 |
| R01DK117850 | Systems Genetics Dissection of Non-alcoholic Steatohepatitis | 2 | 2025 |
| T32AR060719 | Skeletal Disorders Training Program | 2 | 2025 |
| T32GM008243 | UCLA Medical Genetics Training Program | 2 | 2025 |
| UL1TR001881 | UCLA Clinical and Translational Science Institute | 2 | 2025 |
1 to 10 of 802Source NIH's project files
See all 802 nih grantsPapers1,327
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrative Multi-Omics and Machine Learning Reveal Senescent Fibroblast-Associated ADAMTS2 as a Critical Indicator of Intestinal Inflammation in IBD. | FASEB J | 2026 | 42773852 | PubTator, text mining | PubMed |
| RNAemia and Severe COVID-19: Candidate Treatment Targets Identified Through Transcriptomics. | J Infect Dis | 2026 | 42525560 | PubTator, text mining | PubMed |
| Greenspace Exposure and DNA Methylation Age Acceleration: A Systematic Review and Molecular Pathway Analysis. | Int J Mol Sci | 2026 | 42511878 | PubTator, text mining | PubMed |
| Transcriptome-wide m6A Methylation Profiling Reveals Regulatory Networks During Endothelial Differentiation of Bone Marrow Mesenchymal Stem Cells. | Clin Appl Thromb Hemost | 2026 | 42501017 | PubTator, text mining | PubMed |
| Consensus-based detection of aetiologic copy number variants for syndromic orofacial clefts utilising whole exome sequencing of case parent trios. | BMC Genom Data | 2026 | 42420839 | PubTator, text mining | PubMed |
| Distinct Molecular Signature of Earlobe Keloids: Integrated Transcriptomic Analysis of Extracellualr Matrix, Metalloproteinase, and Metabolic Pathways. | Aesthetic Plast Surg | 2026 | 42414644 | PubTator, text mining | PubMed |
| Exploring the Hemorrhagic Manifestations of an Adolescent With Dermatosparaxis-Type Ehlers-Danlos Syndrome: A Case Report. | Cureus | 2026 | 42261541 | PubTator, text mining | PubMed |
| Hypoxia reprograms VEGF signaling to differentially control ADAMTS2 and ADAMTS3 expression in endothelial cells. | Tissue Cell | 2026 | 42224870 | PubTator, text mining | PubMed |
| ADAMTS2 drives prostate cancer progression by activating FAK/PI3K/AKT signaling and suppressing ferroptosis via COL1A1. | Front Oncol | 2026 | 42125710 | PubTator, text mining | PubMed |
| ADAMTS2 Modulates Inflammation, Autophagy, and Barrier Integrity Through PI3K/AKT/mTOR Signaling in LPS-Induced Acute Respiratory Distress Syndrome. | Immun Inflamm Dis | 2026 | 42011035 | PubTator, text mining | PubMed |
1 to 10 of 1,327
See all 1,327 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9509
GET https://conductscience.org/api/genes/v1/9509/patents?page=2