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Gene · 9536

PTGES: prostaglandin E synthase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PTGES: prostaglandin E synthase. Genes, record 9536. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9536

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Gene

Symbol
PTGES
HGNC
Name
prostaglandin E synthase
HGNC
NCBI Gene ID
9536
NCBI Gene
HGNC ID
HGNC:9599
HGNC
Ensembl
ENSG00000148344
NCBI Gene
Aliases
MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14684Prostaglandin E synthase15218Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459415O14684Espacenet
EP 4650780 A22025-11-196738O14684Espacenet
JP 2025529142 A2025-09-043623O14684Espacenet
US 12371689 B22025-07-293623O14684Espacenet
JP 2025517970 A2025-06-126738O14684Espacenet
US 12023385 B22024-07-0233O14684Espacenet
US 12000003 B22024-06-0448O14684Espacenet
EP 4119552 A12023-01-1847O14684Espacenet
US 11446398 B22022-09-2067469O14684Espacenet
JP 2022524081 A2022-04-27170440O14684Espacenet

1 to 10 of 60

See all 60 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,471

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePTGES papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
R01NS100947Inflammatory regulation of epileptogenesis after status epilepticus102025
P30CA068485Cancer Center Support Grant62025
P30ES013508Center of Excellence in Environmental Toxicology62025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202852025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30ES001247Environmental Agents as Modulators of Disease Processes52025
R01AI078908Control of Pulmonary Inflammation by Leukotriene E452025
R01ES004738Activated Macrophages and Ozone Toxicity52025
U19AI095219Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease52025

1 to 10 of 1,471Source NIH's project files

See all 1,471 nih grants

Papers2,865

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
EGFR and PGE2 signaling pathways mutually cooperate to promote pro-tumorigenic effects in cervical cancer.Biochim Biophys Acta Mol Basis Dis202742669370PubTator, text miningPubMed
Transcription Factor XBP1s Impairs Endometrial Receptivity by Promoting ENO1-Mediated Glycolysis and Lactate Production.Cells202642782756PubTator, text miningPubMed
Unveiling the molecular toxicity of plasticizers derived from microplastics (DMP and DEP) in diabetic kidney disease: integrative insights from network toxicology and multi-omics analysis.Front Immunol202642719741PubTator, text miningPubMed
Cell-specific cPGES control of glucocorticoid receptor function drives MASLD progression.Cell Rep202642664055PubTator, text miningPubMed
Adaptive proteomic remodeling and eNOS upregulation in luminal endothelium and perivascular adipose tissue of patent saphenous vein grafts after CABG.Cardiovasc Pathol202642594976PubTator, text miningPubMed
Integrative omics and network pharmacology analysis of Glossocardia bosvallia L. phytocompounds for non-small cell lung carcinoma: Multi-target mechanism and molecular insights.Comput Biol Chem202642585776PubTator, text miningPubMed
Multi-omics study of ABCA1 in sepsis: Integrating mendelian randomisation, single-cell transcriptomics, in silico knockout and virtual screening.Comput Biol Chem202642570643PubTator, text miningPubMed
Antipyretic and Antinociceptive Activities of Tri-Phol-That Extract and Its Flavonoids: In Vivo and In Silico Evidence.ACS Omega202642518421PubTator, text miningPubMed
5-Fluorouracil loaded copper‑aluminum layered double hydroxides inhibit colorectal cancer cells by inducing oxidative stress, mitochondrial membrane depolarization, apoptosis, and cell cycle arrest.Bioorg Chem202642456411PubTator, text miningPubMed
Retraction: Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis.PLoS One202642378186PubTator, text miningPubMed

1 to 10 of 2,865

See all 2,865 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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