Gene · 9536
PTGES: prostaglandin E synthase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PTGES: prostaglandin E synthase. Genes, record 9536. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9536
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14684 | Prostaglandin E synthase | 152 | 18 | Ensembl, GeneID, HGNC |
Source UniProt
Patents60
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 59415 | O14684 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 6738 | O14684 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3623 | O14684 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3623 | O14684 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6738 | O14684 | Espacenet |
| US 12023385 B2 | 2024-07-02 | 33 | O14684 | Espacenet |
| US 12000003 B2 | 2024-06-04 | 48 | O14684 | Espacenet |
| EP 4119552 A1 | 2023-01-18 | 47 | O14684 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 67469 | O14684 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 170440 | O14684 | Espacenet |
1 to 10 of 60
See all 60 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,471
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PTGES papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| R01NS100947 | Inflammatory regulation of epileptogenesis after status epilepticus | 10 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 6 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 5 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 5 | 2025 |
| P30ES001247 | Environmental Agents as Modulators of Disease Processes | 5 | 2025 |
| R01AI078908 | Control of Pulmonary Inflammation by Leukotriene E4 | 5 | 2025 |
| R01ES004738 | Activated Macrophages and Ozone Toxicity | 5 | 2025 |
| U19AI095219 | Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease | 5 | 2025 |
1 to 10 of 1,471Source NIH's project files
See all 1,471 nih grantsPapers2,865
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| EGFR and PGE2 signaling pathways mutually cooperate to promote pro-tumorigenic effects in cervical cancer. | Biochim Biophys Acta Mol Basis Dis | 2027 | 42669370 | PubTator, text mining | PubMed |
| Transcription Factor XBP1s Impairs Endometrial Receptivity by Promoting ENO1-Mediated Glycolysis and Lactate Production. | Cells | 2026 | 42782756 | PubTator, text mining | PubMed |
| Unveiling the molecular toxicity of plasticizers derived from microplastics (DMP and DEP) in diabetic kidney disease: integrative insights from network toxicology and multi-omics analysis. | Front Immunol | 2026 | 42719741 | PubTator, text mining | PubMed |
| Cell-specific cPGES control of glucocorticoid receptor function drives MASLD progression. | Cell Rep | 2026 | 42664055 | PubTator, text mining | PubMed |
| Adaptive proteomic remodeling and eNOS upregulation in luminal endothelium and perivascular adipose tissue of patent saphenous vein grafts after CABG. | Cardiovasc Pathol | 2026 | 42594976 | PubTator, text mining | PubMed |
| Integrative omics and network pharmacology analysis of Glossocardia bosvallia L. phytocompounds for non-small cell lung carcinoma: Multi-target mechanism and molecular insights. | Comput Biol Chem | 2026 | 42585776 | PubTator, text mining | PubMed |
| Multi-omics study of ABCA1 in sepsis: Integrating mendelian randomisation, single-cell transcriptomics, in silico knockout and virtual screening. | Comput Biol Chem | 2026 | 42570643 | PubTator, text mining | PubMed |
| Antipyretic and Antinociceptive Activities of Tri-Phol-That Extract and Its Flavonoids: In Vivo and In Silico Evidence. | ACS Omega | 2026 | 42518421 | PubTator, text mining | PubMed |
| 5-Fluorouracil loaded copper‑aluminum layered double hydroxides inhibit colorectal cancer cells by inducing oxidative stress, mitochondrial membrane depolarization, apoptosis, and cell cycle arrest. | Bioorg Chem | 2026 | 42456411 | PubTator, text mining | PubMed |
| Retraction: Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis. | PLoS One | 2026 | 42378186 | PubTator, text mining | PubMed |
1 to 10 of 2,865
See all 2,865 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9536
GET https://conductscience.org/api/genes/v1/9536/patents?page=2