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Gene · 9568

GABBR2: gamma-aminobutyric acid type B receptor subunit 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GABBR2: gamma-aminobutyric acid type B receptor subunit 2. Genes, record 9568. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9568

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Gene

Symbol
GABBR2
HGNC
Name
gamma-aminobutyric acid type B receptor subunit 2
HGNC
NCBI Gene ID
9568
NCBI Gene
HGNC ID
HGNC:4507
HGNC
Ensembl
ENSG00000136928
NCBI Gene
Aliases
DEE59, EIEE59, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, NDPLHS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75899Gamma-aminobutyric acid type B receptor subunit 294126Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1447279O75899Espacenet
EP 4641201 A22025-10-291341O75899Espacenet
JP 2025529142 A2025-09-041651O75899Espacenet
US 12371689 B22025-07-291651O75899Espacenet
JP 2025517969 A2025-06-121341O75899Espacenet
JP 2025032204 A2025-03-1128733O75899Espacenet
EP 4461818 A22024-11-1328733O75899Espacenet
JP 2023058610 A2023-04-2528733O75899Espacenet
US 11446398 B22022-09-2034019O75899Espacenet
US 11400116 B22022-08-023288O75899Espacenet

1 to 10 of 49

See all 49 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARBACLOFENCHEMBL301742GABA-B receptor agonistAGONISTChEMBL
ARBACLOFEN PLACARBILCHEMBL2107312GABA-B receptor agonistAGONISTChEMBL
BACLOFENCHEMBL701GABA-B receptor agonistAGONISTChEMBL
CALCIUM OXYBATECHEMBL4594393GABA-B receptor agonistAGONISTChEMBL
LESOGABERANCHEMBL448343GABA-B receptor 2 agonistAGONISTChEMBL
MAGNESIUM OXYBATECHEMBL4594394GABA-B receptor agonistAGONISTChEMBL
OXYBATECHEMBL1342GABA-B receptor agonistAGONISTChEMBL
POTASSIUM OXYBATECHEMBL4594395GABA-B receptor agonistAGONISTChEMBL
SGS-742CHEMBL112797GABA-B receptor antagonistANTAGONISTChEMBL
SODIUM OXYBATECHEMBL1200682GABA-B receptor agonistAGONISTChEMBL

Trials128

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07596342OXYBATEPHASE2ClinicalTrials.gov
NCT07560878BACLOFENEARLY_PHASE1ClinicalTrials.gov
NCT07378046BACLOFENClinicalTrials.gov
NCT07063576BACLOFENPHASE2/PHASE3ClinicalTrials.gov
NCT07041203SODIUM OXYBATEPHASE1ClinicalTrials.gov
NCT06840652BACLOFENClinicalTrials.gov
NCT06809803SODIUM OXYBATEPHASE2ClinicalTrials.gov
NCT06792708SODIUM OXYBATEClinicalTrials.gov
NCT06564714BACLOFENPHASE4ClinicalTrials.gov
NCT06525077SODIUM OXYBATEPHASE3ClinicalTrials.gov

1 to 10 of 128

See all 128 trials

NIH grants1,295

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGABBR2 papersNewest fiscal year
R01MH084894Function of GPCR heteromeric complexes in brain82025
R01AA012404Gene Expression in the Human Alcoholic Brain62025
R28AA012725Brain Tissue Resource Center for Alcohol Research42025
P30CA008748Cancer Center Support Grant32025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital32025
P30DK063491Diabetes Research Center (DRC)32025
R01AI139618Nucleoside-modified mRNA vaccine for prevention and treatment of genital herpes32025
R01DA036596Regulation of Neuronal GPCR Signaling32025
R01HL059949Structural Determinants of PIP2 Regulation32025
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).32025

1 to 10 of 1,295Source NIH's project files

See all 1,295 nih grants

Papers1,378

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Heterozygous Variant in the GABBR2 Gene in a Girl With Clinical Classic Rett Syndrome.Mol Genet Genomic Med202642802491PubTator, text miningPubMed
A Cross-Matrix Peripheral Transcriptional Signature in Suicide Attempt: NR3C2 Downregulation in Blood and Buccal Swab Samples.Int J Mol Sci202642653190PubTator, text miningPubMed
Functional dissection of HCMV gB's autonomous fusion activity provides insights into how polymorphisms in clinical isolates confer distinct characteristics.mBio202642439560PubTator, text miningPubMed
Endothelial GABA protects against aortic dissection by inhibiting endothelial and mitochondrial dysfunction and maintaining vascular homeostasis.Signal Transduct Target Ther202642031717PubTator, text miningPubMed
Heterogeneity of monogenic epilepsy in loci, phenotypes, and treatment approaches.Neurol Sci202641912906PubTator, text miningPubMed
Predictive value of gB2 antibodies for maternal-fetal transmission after primary cytomegalovirus infection treated with valacyclovir.Ultrasound Obstet Gynecol202641906968PubTator, text miningPubMed
FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy.FASEB J202641808415PubTator, text miningPubMed
Functional signatures of de novo GABBR1 and GABBR2 variants associated with neurodevelopmental disorders.NPJ Genom Med202641803176PubTator, text miningPubMed
Temporal lobe epilepsy is associated with neuroinflammation, extracellular matrix remodeling, and synaptic protein alterations.Front Mol Neurosci202641800185PubTator, text miningPubMed
Essential tremor: Family-based sequencing suggests involvement of neuronal and metabolic pathways.Parkinsonism Relat Disord202641762786PubTator, text miningPubMed

1 to 10 of 1,378

See all 1,378 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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