Gene · 9568
GABBR2: gamma-aminobutyric acid type B receptor subunit 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. GABBR2: gamma-aminobutyric acid type B receptor subunit 2. Genes, record 9568. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9568
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O75899 | Gamma-aminobutyric acid type B receptor subunit 2 | 941 | 26 | Ensembl, GeneID, HGNC |
Source UniProt
Patents49
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 47279 | O75899 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1341 | O75899 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1651 | O75899 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1651 | O75899 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1341 | O75899 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 28733 | O75899 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 28733 | O75899 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 28733 | O75899 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 34019 | O75899 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3288 | O75899 | Espacenet |
1 to 10 of 49
See all 49 patentsDrugs10
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ARBACLOFEN | CHEMBL301742 | GABA-B receptor agonist | AGONIST | ChEMBL |
| ARBACLOFEN PLACARBIL | CHEMBL2107312 | GABA-B receptor agonist | AGONIST | ChEMBL |
| BACLOFEN | CHEMBL701 | GABA-B receptor agonist | AGONIST | ChEMBL |
| CALCIUM OXYBATE | CHEMBL4594393 | GABA-B receptor agonist | AGONIST | ChEMBL |
| LESOGABERAN | CHEMBL448343 | GABA-B receptor 2 agonist | AGONIST | ChEMBL |
| MAGNESIUM OXYBATE | CHEMBL4594394 | GABA-B receptor agonist | AGONIST | ChEMBL |
| OXYBATE | CHEMBL1342 | GABA-B receptor agonist | AGONIST | ChEMBL |
| POTASSIUM OXYBATE | CHEMBL4594395 | GABA-B receptor agonist | AGONIST | ChEMBL |
| SGS-742 | CHEMBL112797 | GABA-B receptor antagonist | ANTAGONIST | ChEMBL |
| SODIUM OXYBATE | CHEMBL1200682 | GABA-B receptor agonist | AGONIST | ChEMBL |
Trials128
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07596342 | OXYBATE | PHASE2 | ClinicalTrials.gov | |
| NCT07560878 | BACLOFEN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07378046 | BACLOFEN | ClinicalTrials.gov | ||
| NCT07063576 | BACLOFEN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07041203 | SODIUM OXYBATE | PHASE1 | ClinicalTrials.gov | |
| NCT06840652 | BACLOFEN | ClinicalTrials.gov | ||
| NCT06809803 | SODIUM OXYBATE | PHASE2 | ClinicalTrials.gov | |
| NCT06792708 | SODIUM OXYBATE | ClinicalTrials.gov | ||
| NCT06564714 | BACLOFEN | PHASE4 | ClinicalTrials.gov | |
| NCT06525077 | SODIUM OXYBATE | PHASE3 | ClinicalTrials.gov |
1 to 10 of 128
See all 128 trialsNIH grants1,295
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | GABBR2 papers | Newest fiscal year |
|---|---|---|---|
| R01MH084894 | Function of GPCR heteromeric complexes in brain | 8 | 2025 |
| R01AA012404 | Gene Expression in the Human Alcoholic Brain | 6 | 2025 |
| R28AA012725 | Brain Tissue Resource Center for Alcohol Research | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30DK043351 | Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital | 3 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 3 | 2025 |
| R01AI139618 | Nucleoside-modified mRNA vaccine for prevention and treatment of genital herpes | 3 | 2025 |
| R01DA036596 | Regulation of Neuronal GPCR Signaling | 3 | 2025 |
| R01HL059949 | Structural Determinants of PIP2 Regulation | 3 | 2025 |
| U10AA008401 | Collaborative Study on the Genetics of Alcoholism (COGA). | 3 | 2025 |
1 to 10 of 1,295Source NIH's project files
See all 1,295 nih grantsPapers1,378
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A Heterozygous Variant in the GABBR2 Gene in a Girl With Clinical Classic Rett Syndrome. | Mol Genet Genomic Med | 2026 | 42802491 | PubTator, text mining | PubMed |
| A Cross-Matrix Peripheral Transcriptional Signature in Suicide Attempt: NR3C2 Downregulation in Blood and Buccal Swab Samples. | Int J Mol Sci | 2026 | 42653190 | PubTator, text mining | PubMed |
| Functional dissection of HCMV gB's autonomous fusion activity provides insights into how polymorphisms in clinical isolates confer distinct characteristics. | mBio | 2026 | 42439560 | PubTator, text mining | PubMed |
| Endothelial GABA protects against aortic dissection by inhibiting endothelial and mitochondrial dysfunction and maintaining vascular homeostasis. | Signal Transduct Target Ther | 2026 | 42031717 | PubTator, text mining | PubMed |
| Heterogeneity of monogenic epilepsy in loci, phenotypes, and treatment approaches. | Neurol Sci | 2026 | 41912906 | PubTator, text mining | PubMed |
| Predictive value of gB2 antibodies for maternal-fetal transmission after primary cytomegalovirus infection treated with valacyclovir. | Ultrasound Obstet Gynecol | 2026 | 41906968 | PubTator, text mining | PubMed |
| FNDC1 Competitively Binds Gβ2 to Suppress the β-Catenin-Destruction Complex and Promote Gastric Cancer Malignancy. | FASEB J | 2026 | 41808415 | PubTator, text mining | PubMed |
| Functional signatures of de novo GABBR1 and GABBR2 variants associated with neurodevelopmental disorders. | NPJ Genom Med | 2026 | 41803176 | PubTator, text mining | PubMed |
| Temporal lobe epilepsy is associated with neuroinflammation, extracellular matrix remodeling, and synaptic protein alterations. | Front Mol Neurosci | 2026 | 41800185 | PubTator, text mining | PubMed |
| Essential tremor: Family-based sequencing suggests involvement of neuronal and metabolic pathways. | Parkinsonism Relat Disord | 2026 | 41762786 | PubTator, text mining | PubMed |
1 to 10 of 1,378
See all 1,378 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9568
GET https://conductscience.org/api/genes/v1/9568/patents?page=2