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Gene · 9572

NR1D1: nuclear receptor subfamily 1 group D member 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NR1D1: nuclear receptor subfamily 1 group D member 1. Genes, record 9572. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9572

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Gene

Symbol
NR1D1
HGNC
Name
nuclear receptor subfamily 1 group D member 1
HGNC
NCBI Gene ID
9572
NCBI Gene
HGNC ID
HGNC:7962
HGNC
Ensembl
ENSG00000126368
NCBI Gene
Aliases
EAR1, REVERBA, REVERBalpha, Rev-ErbAalpha, THRA1, THRAL, ear-1, hRev
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20393Nuclear receptor subfamily 1 group D member 16145Ensembl, GeneID, HGNC

Source UniProt

Patents54

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456141P20393Espacenet
US 12496298 B22025-12-164P20393Espacenet
EP 4650780 A22025-11-191198P20393Espacenet
EP 4641201 A22025-10-29851P20393Espacenet
JP 2025147176 A2025-10-0615415P20393Espacenet
JP 2025517969 A2025-06-12851P20393Espacenet
JP 2025517970 A2025-06-121198P20393Espacenet
JP 2025028160 A2025-02-2815415P20393Espacenet
KR 1020250010750 A2025-01-2115415P20393Espacenet
JP 2024109657 A2024-08-1415254P20393Espacenet

1 to 10 of 54

See all 54 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,343

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNR1D1 papersNewest fiscal year
P30DK019525University of Pennsylvania Diabetes Research Center172025
P30CA014195Cancer Center Support Grant (CCSG)82025
P30DK072476Pennington/Louisiana NORC72025
P30ES013508Center of Excellence in Environmental Toxicology72025
R01CA051497Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis62025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P30DK056338Texas Medical Center Digestive Diseases Center52025
ZIABC011191Preclinical Mouse Models of Thyroid Cancer52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025

1 to 10 of 1,343Source NIH's project files

See all 1,343 nih grants

Papers2,029

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Diurnal Insulin Clearance and Circadian Metabolic Gene Signatures in MASLD: Integrative Multi-Dataset Physiological and Transcriptomic Analysis.Metabolites202642783754PubTator, text miningPubMed
Leptin Associates with Circadian Light Hygiene and REV-ERBα in Arctic Residents.Bull Exp Biol Med202642771238PubTator, text miningPubMed
Targeting the NR1D1-IGF2BP2-V-ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis-Induced Immunosuppression.Adv Sci (Weinh)202642636084PubTator, text miningPubMed
Letter to "NR1D2 Knockdown Alleviates Myocardial Infarction Through Nrf2 Signaling Pathway Activation".Cardiovasc Drugs Ther202642579208PubTator, text miningPubMed
Dictamnine alleviates oxidative stress in rheumatoid arthritis via modulation of the NR1D1-Keap1/Nrf2/ARE axis.Bioorg Chem202642520520PubTator, text miningPubMed
Impact of Core Circadian Gene Variants on Glycemic Parameters and Insulin Resistance in Type 2 Diabetes: A Systematic Review.Cureus202642504374PubTator, text miningPubMed
Retraction notice to "SR9009 attenuates inflammation-related NPMSC pyroptosis and IVDD through NR1D1/NLRP3/IL-1β pathway" [iScience 27 (2024) 109733].iScience202642491751PubTator, text miningPubMed
Stephanoside B modulates metabolic gene expression and lengthens the circadian bmal1 oscillation period in differentiated myotubes revealed by real-time bioluminescence.Mol Biol Rep202642484698PubTator, text miningPubMed
Immune-stromal dysregulation and senescence in chronic spontaneous urticaria.J Allergy Clin Immunol Glob202642436760PubTator, text miningPubMed
Neuroinflammatory suppression of astrocytic BMAL1 defines a selective reactive astrocyte program.J Neuroinflammation202642421063PubTator, text miningPubMed

1 to 10 of 2,029

See all 2,029 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9572

GET https://conductscience.org/api/genes/v1/9572/patents?page=2