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CLOCK: clock circadian regulator

1 protein, 54 patents, 0 drugs, 0 trials, 3,497 NIH grants and 5,569 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCLOCKHGNC
Nameclock circadian regulatorHGNC
NCBI Gene ID9575NCBI Gene
HGNC IDHGNC:2082HGNC
EnsemblENSG00000134852NCBI Gene
AliasesKAT13D, KIAA0334, bHLHe8NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15516Circadian locomoter output cycles protein kaput8462Ensembl, GeneID, HGNCUniProt

Patents 54

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441674O15516Espacenet
EP 4650780 A22025-11-194576O15516Espacenet
EP 4641201 A22025-10-294135O15516Espacenet
JP 2025147176 A2025-10-0614836O15516Espacenet
JP 2025517969 A2025-06-124135O15516Espacenet
JP 2025517970 A2025-06-124576O15516Espacenet
JP 2025028160 A2025-02-2814836O15516Espacenet
KR 1020250010750 A2025-01-2114836O15516Espacenet
JP 2024109657 A2024-08-1414675O15516Espacenet
US 11564998 B22023-01-315306O15516Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3497

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01DK090625Integration of Feeding Time and Glucose Metabolism by the Circadian Gene Network142,025NIH's project files
T32HL007909Training Grant in Circadian and Sleep Research-Resubmission122,025NIH's project files
P30DK056338Texas Medical Center Digestive Diseases Center112,025NIH's project files
R01CA051497Defining the Role of the Cancer Circadian Clock in Tumor Immunity and Tumorigenesis102,025NIH's project files
P30AG028740University of Florida Older Americans Independence Center (OAIC)92,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)92,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology92,025NIH's project files
T32HL007901Training in Sleep, Circadian, and Respiratory Neurobiology92,025NIH's project files
P30CA016672Cancer Center Support Grant82,025NIH's project files
P30DK056336UAB Nutrition Obesity Research Center (NORC)82,025NIH's project files

Papers 5569

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42793001PubTator, text miningPubMed
42788273PubTator, text miningPubMed
42783754PubTator, text miningPubMed
42778625PubTator, text miningPubMed
42774343PubTator, text miningPubMed
42754851PubTator, text miningPubMed
42725517PubTator, text miningPubMed
42708270PubTator, text miningPubMed
42703617PubTator, text miningPubMed
42694455PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license