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CD40: CD40 molecule

1 protein, 604 patents, 11 drugs, 77 trials, 12,353 NIH grants and 28,872 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCD40HGNC
NameCD40 moleculeHGNC
NCBI Gene ID958NCBI Gene
HGNC IDHGNC:11919HGNC
EnsemblENSG00000101017NCBI Gene
AliasesBp50, CDW40, TNFRSF5, p50NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P25942Tumor necrosis factor receptor superfamily member 527714Ensembl, GeneID, HGNCUniProt

Patents 604

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4820387 A12026-10-1437P25942Espacenet
EP 4801963 A12026-09-09141P25942Espacenet
WO 2026167079 A12026-08-1379P25942Espacenet
WO 2026167093 A12026-08-1354P25942Espacenet
WO 2026167100 A12026-08-13141P25942Espacenet
EP 4755464 A22026-06-10115P25942Espacenet
US 12612463 B22026-04-281P25942Espacenet
EP 4713439 A12026-03-25247P25942Espacenet
JP 2026053377 A2026-03-251P25942Espacenet
EP 4705273 A22026-03-11318P25942Espacenet

Drugs 11

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BLESELUMABCHEMBL3990028Tumor necrosis factor receptor superfamily member 5 inhibitorINHIBITORChEMBL
CD40 LIGANDCHEMBL4297718Tumor necrosis factor receptor superfamily member 5 agonistAGONISTChEMBL
CDX-1140CHEMBL4297721Tumor necrosis factor receptor superfamily member 5 agonistAGONISTChEMBL
DACETUZUMABCHEMBL1743005Tumor necrosis factor receptor superfamily member 5 inhibitorINHIBITORChEMBL
GILORALIMABCHEMBL4594517Tumor necrosis factor receptor superfamily member 5 agonistAGONISTChEMBL
ISCALIMABCHEMBL4298210Tumor necrosis factor receptor superfamily member 5 inhibitorINHIBITORChEMBL
LUCATUMUMABCHEMBL1743038Tumor necrosis factor receptor superfamily member 5 antagonistANTAGONISTChEMBL
PG-102CHEMBL2109475Tumor necrosis factor receptor superfamily member 5 inhibitorINHIBITORChEMBL
SELICRELUMABCHEMBL2109477Tumor necrosis factor receptor superfamily member 5 agonistAGONISTChEMBL
SOTIGALIMABCHEMBL4297888Tumor necrosis factor receptor superfamily member 5 agonistAGONISTChEMBL

Trials 77

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07187856PG-102PHASE2ClinicalTrials.gov
NCT06980038CDX-1140PHASE2ClinicalTrials.gov
NCT06712615PG-102PHASE2ClinicalTrials.gov
NCT06309667PG-102PHASE1ClinicalTrials.gov
NCT05484011CDX-1140PHASE1ClinicalTrials.gov
NCT05419479SOTIGALIMABPHASE1/PHASE2ClinicalTrials.gov
NCT05349890CDX-1140PHASE1ClinicalTrials.gov
NCT05231122CDX-1140PHASE2ClinicalTrials.gov
NCT05201001SOTIGALIMABPHASE2ClinicalTrials.gov
NCT05029999CDX-1140PHASE1ClinicalTrials.gov

NIH grants 12353

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant1162,025NIH's project files
P30CA008748Cancer Center Support Grant1092,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant382,025NIH's project files
P30CA023108Cancer Center Support Grant352,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award352,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program332,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant332,025NIH's project files
P30CA047904Cancer Center Support Grant292,025NIH's project files
P51OD011132Emory National Primate Research Center292,025NIH's project files
P30CA086862Cancer Center Support Grant272,025NIH's project files

Papers 28872

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826780PubTator, text miningPubMed
42818447PubTator, text miningPubMed
42808109PubTator, text miningPubMed
42802264PubTator, text miningPubMed
42797545PubTator, text miningPubMed
42792912PubTator, text miningPubMed
42787960PubTator, text miningPubMed
42782738PubTator, text miningPubMed
42777607PubTator, text miningPubMed
42776797PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license