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CD40LG: CD40 ligand

1 protein, 708 patents, 6 drugs, 26 trials, 10,045 NIH grants and 23,000 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCD40LGHGNC
NameCD40 ligandHGNC
NCBI Gene ID959NCBI Gene
HGNC IDHGNC:11935HGNC
EnsemblENSG00000102245NCBI Gene
AliasesCD154, CD40-L, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40LNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29965CD40 ligand2618Ensembl, GeneID, HGNCUniProt

Patents 708

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4825391 A12026-10-212P29965Espacenet
WO 2026183237 A12026-09-03273P29965Espacenet
EP 4754237 A12026-06-1024P29965Espacenet
JP 2026094244 A2026-06-091P29965Espacenet
JP 2026089698 A2026-06-0155P29965Espacenet
JP 2026086743 A2026-05-26161P29965Espacenet
JP 2026516844 A2026-05-2627P29965Espacenet
EP 4725503 A22026-04-152628P29965Espacenet
EP 4705273 A22026-03-11332P29965Espacenet
EP 4703385 A12026-03-0427P29965Espacenet

Drugs 6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DAPIROLIZUMAB PEGOLCHEMBL2109478CD40 ligand inhibitorINHIBITORChEMBL
DAZODALIBEPCHEMBL4594331CD40 ligand antagonistANTAGONISTChEMBL
RAVAGALIMABCHEMBL4298212CD40 ligand antagonistANTAGONISTChEMBL
RUPLIZUMABCHEMBL2108767CD40 ligand inhibitorINHIBITORChEMBL
TEGOPRUBARTCHEMBL4594460CD40 ligand inhibitorINHIBITORChEMBL
TORALIZUMABCHEMBL2108747CD40 ligand inhibitorINHIBITORChEMBL

Trials 26

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07592000TEGOPRUBARTPHASE1/PHASE2ClinicalTrials.gov
NCT06972446RAVAGALIMABPHASE2ClinicalTrials.gov
NCT06972069TEGOPRUBARTEARLY_PHASE1ClinicalTrials.gov
NCT06747949DAZODALIBEPPHASE3ClinicalTrials.gov
NCT06617325DAPIROLIZUMAB PEGOLPHASE3ClinicalTrials.gov
NCT06305286TEGOPRUBARTPHASE1/PHASE2ClinicalTrials.gov
NCT06245408DAZODALIBEPPHASE3ClinicalTrials.gov
NCT06126380TEGOPRUBARTPHASE2ClinicalTrials.gov
NCT06104124DAZODALIBEPPHASE3ClinicalTrials.gov
NCT05480657TEGOPRUBARTPHASE1/PHASE2ClinicalTrials.gov

NIH grants 10045

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant942,025NIH's project files
P30CA008748Cancer Center Support Grant722,025NIH's project files
P30ES001247Environmental Agents as Modulators of Disease Processes462,025NIH's project files
P51OD011132Emory National Primate Research Center462,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award432,025NIH's project files
UM1AI068618HIV Vaccine Trials Network Laboratory Center392,025NIH's project files
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro282,025NIH's project files
UM1AI068635SDMC: HIV Vaccine Trials Network262,025NIH's project files
P30AI050409Center for AIDS Research at Emory University252,025NIH's project files
P30CA047904Cancer Center Support Grant242,025NIH's project files

Papers 23000

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818065PubTator, text miningPubMed
42809927PubTator, text miningPubMed
42808109PubTator, text miningPubMed
42800817PubTator, text miningPubMed
42781451PubTator, text miningPubMed
42780644PubTator, text miningPubMed
42769299PubTator, text miningPubMed
42768790PubTator, text miningPubMed
42767973PubTator, text miningPubMed
42763247PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license