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KLK4: kallikrein related peptidase 4

1 protein, 34 patents, 0 drugs, 0 trials, 3,000 NIH grants and 10,349 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolKLK4HGNC
Namekallikrein related peptidase 4HGNC
NCBI Gene ID9622NCBI Gene
HGNC IDHGNC:6365HGNC
EnsemblENSG00000167749NCBI Gene
AliasesAI2A1, ARM1, EMSP, EMSP1, KLK-L1, PRSS17, PSTS, kallikreinNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9Y5K2Kallikrein-425418Ensembl, GeneID, HGNCUniProt

Patents 34

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450566Q9Y5K2Espacenet
JP 2025529142 A2025-09-046828Q9Y5K2Espacenet
US 12371689 B22025-07-296828Q9Y5K2Espacenet
EP 4487869 A22025-01-08253Q9Y5K2Espacenet
KR 1020240027895 A2024-03-04443Q9Y5K2Espacenet
JP 2023036863 A2023-03-14443Q9Y5K2Espacenet
US 10918740 B22021-02-162113Q9Y5K2Espacenet
US 10869935 B22020-12-222113Q9Y5K2Espacenet
EP 3680335 A12020-07-1530Q9Y5K2Espacenet
JP 2020518613 A2020-06-25443Q9Y5K2Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3000

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P50CA092629SPORE in Prostate Cancer662,025NIH's project files
P30CA008748Cancer Center Support Grant582,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI192,025NIH's project files
P30CA016672Cancer Center Support Grant122,025NIH's project files
P30DK036836Diabetes Research Center122,025NIH's project files
R01HL144113Contact Pathway Activation on Vascular Devices112,025NIH's project files
ZIAAI000810Vector-Borne Diseases: Biology Of Vector Host Relationship92,025NIH's project files
P50CA097186The Pacific Northwest Prostate Cancer SPORE82,025NIH's project files
R01NS102721Contact System and Alzheimer's Disease: Mechanism and Therapeutic Potential82,025NIH's project files
P30CA006973Regional Oncology Research Center72,025NIH's project files

Papers 10349

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820647PubTator, text miningPubMed
42781533PubTator, text miningPubMed
42760018PubTator, text miningPubMed
42755375PubTator, text miningPubMed
42734496PubTator, text miningPubMed
42720486PubTator, text miningPubMed
42716572PubTator, text miningPubMed
42650831PubTator, text miningPubMed
42633042PubTator, text miningPubMed
42628751PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license