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ISG15: ISG15 ubiquitin like modifier

1 protein, 82 patents, 0 drugs, 0 trials, 5,255 NIH grants and 8,244 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolISG15HGNC
NameISG15 ubiquitin like modifierHGNC
NCBI Gene ID9636NCBI Gene
HGNC IDHGNC:4053HGNC
EnsemblENSG00000187608NCBI Gene
AliasesG1P2, IFI15, IMD38, IP17, UCRP, hUCRPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P05161Ubiquitin-like protein ISG1516523Ensembl, GeneID, HGNCUniProt

Patents 82

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450414P05161Espacenet
EP 4650780 A22025-11-1919551P05161Espacenet
JP 2025517970 A2025-06-1219551P05161Espacenet
JP 2025503207 A2025-01-3015P05161Espacenet
US 11884978 B22024-01-30554P05161Espacenet
KR 1020230165003 A2023-12-052P05161Espacenet
WO 2022259904 A2022-12-1536P05161Espacenet
US 11446398 B22022-09-2042073P05161Espacenet
JP 2022524081 A2022-04-27145044P05161Espacenet
KR 1020210130270 A2021-10-2911P05161Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5255

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant322,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success212,025NIH's project files
U19AI135972SARS-CoV adaptations through a Systems Biology Lens (SYBIL)152,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award152,025NIH's project files
P30CA016672Cancer Center Support Grant142,025NIH's project files
T32AI007647Training Program in Mechanisms of Virus-Host Interactions142,025NIH's project files
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy142,025NIH's project files
P30CA016087Cancer Center Support Grant122,025NIH's project files
P51OD010425Washington National Primate Research Center122,025NIH's project files
P51OD011132Emory National Primate Research Center122,025NIH's project files

Papers 8244

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826657PubTator, text miningPubMed
42824448PubTator, text miningPubMed
42818784PubTator, text miningPubMed
42815864PubTator, text miningPubMed
42798643PubTator, text miningPubMed
42792959PubTator, text miningPubMed
42792891PubTator, text miningPubMed
42790721PubTator, text miningPubMed
42778089PubTator, text miningPubMed
42774107PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license