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Gene · 9682

KDM4A: lysine demethylase 4A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KDM4A: lysine demethylase 4A. Genes, record 9682. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9682

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Gene

Symbol
KDM4A
HGNC
Name
lysine demethylase 4A
HGNC
NCBI Gene ID
9682
NCBI Gene
HGNC ID
HGNC:22978
HGNC
Ensembl
ENSG00000066135
NCBI Gene
Aliases
JHDM3A, JMJD2, JMJD2A, KIAA0677, TDRD14A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75164Lysine-specific demethylase 4A1,06489Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199096O75164Espacenet
EP 4640849 A22025-10-291361O75164Espacenet
EP 4641201 A22025-10-299367O75164Espacenet
JP 2025519096 A2025-06-241361O75164Espacenet
JP 2025517969 A2025-06-129367O75164Espacenet
JP 2025517970 A2025-06-129096O75164Espacenet
EP 4464338 A22024-11-202287O75164Espacenet
US 11680268 B22023-06-202287O75164Espacenet
JP 2023026679 A2023-02-2450O75164Espacenet
US 11564998 B22023-01-316318O75164Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,410

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKDM4A papersNewest fiscal year
P30CA008748Cancer Center Support Grant142025
P30CA006927Comprehensive Cancer Center Program at Fox Chase102025
P30CA016672Cancer Center Support Grant82025
R01CA132878Post-translational Modifications in DNA Damage Response: a Structural Perspective82025
ZIAAI000712Transcriptional control of herpes simplex virus lytic infection and latency-reactivation cycles82025
P30CA093373Cancer Center Support Grant P3062025
P30CA225520Stephenson Cancer Center - Cancer Center Support Grant62025
P30CA016058Cancer Center Support Grant52025
P30CA022453CANCER CENTER SUPPORT GRANT52025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center52025

1 to 10 of 1,410Source NIH's project files

See all 1,410 nih grants

Papers1,858

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Histone demethylase KDM4A promotes endometrial cancer progression through an ERRγ-associated cell-cycle regulatory axis.Int J Biol Sci202642807380PubTator, text miningPubMed
KDM4A-driven epigenetic reprogramming as a central nexus linking metabolic adaptation, immune remodeling, and therapy resistance in cancer.Crit Rev Oncol Hematol202642624180PubTator, text miningPubMed
Design and synthesis of quinazoline derivatives as novel JMJD3/HDAC dual-target inhibitors.RSC Med Chem202642445800PubTator, text miningPubMed
Integrated structure-based and fragment-guided design of isonicotinic acid derivatives as potential KDM4A inhibitors: an in silico study.J Comput Aided Mol Des202642371179PubTator, text miningPubMed
H2AX C-Terminal Dipeptide Truncation: A Master Switch of the DNA Damage Response.bioRxiv202642182341PubTator, text miningPubMed
Identification of 2-Substituted-3-Hydroxy-2,3-Dihydroquinazolin-4(1H) Ones as Cell-Active Inhibitors of KDM4A Lysine Demethylase.ChemMedChem202642157714PubTator, text miningPubMed
DNASE1L3 functions as a significant metastatic suppressor by attenuating MYH9/β-catenin/c-Jun/LncRNA-KDM4A-induced E-cadherin ubiquitination degradation in nasopharyngeal carcinoma.Cell Mol Biol Lett202642092754PubTator, text miningPubMed
Androgen receptor as a therapeutic target in endometrial cancer: a narrative review.Int J Gynecol Cancer202642070324PubTator, text miningPubMed
The combinations of histone lysine demethylase inhibitors with panobinostat exert enhanced effects against head and neck cancer cells.Exp Cell Res202642019757PubTator, text miningPubMed
Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review.J Cell Mol Med202641928432PubTator, text miningPubMed

1 to 10 of 1,858

See all 1,858 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9682

GET https://conductscience.org/api/genes/v1/9682/patents?page=2