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CD74: CD74 molecule

1 protein, 89 patents, 2 drugs, 16 trials, 3,598 NIH grants and 5,837 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCD74HGNC
NameCD74 moleculeHGNC
NCBI Gene ID972NCBI Gene
HGNC IDHGNC:1697HGNC
EnsemblENSG00000019582NCBI Gene
AliasesCLIP, DHLAG, HLADG, II, Ia-GAMMA, p33NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04233HLA class II histocompatibility antigen gamma chain29624Ensembl, GeneID, HGNCUniProt

Patents 89

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026177163 A2026-08-2712P04233Espacenet
JP 2026090543 A2026-06-02738P04233Espacenet
EP 4680730 A22026-01-2117P04233Espacenet
JP 2026004568 A2026-01-1440626P04233Espacenet
JP 2025529142 A2025-09-04835P04233Espacenet
WO 2025163140 A12025-08-0724P04233Espacenet
US 12371689 B22025-07-29835P04233Espacenet
EP 4582098 A22025-07-091422P04233Espacenet
JP 2025518569 A2025-06-17109P04233Espacenet
JP 2025517332 A2025-06-05140P04233Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
MILATUZUMABCHEMBL1743040HLA-DR antigens-associated invariant chain antagonistANTAGONISTChEMBL
REPOTRECTINIBCHEMBL4298138CD74-ROS1 inhibitorINHIBITORChEMBL

Trials 16

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07599007REPOTRECTINIBClinicalTrials.gov
NCT06552234REPOTRECTINIBPHASE2ClinicalTrials.gov
NCT06408168REPOTRECTINIBPHASE2ClinicalTrials.gov
NCT06315010REPOTRECTINIBPHASE2ClinicalTrials.gov
NCT06140836REPOTRECTINIBPHASE3ClinicalTrials.gov
NCT05004116REPOTRECTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT04772235REPOTRECTINIBPHASE1ClinicalTrials.gov
NCT04094610REPOTRECTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT03093116REPOTRECTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT01845740MILATUZUMABPHASE1ClinicalTrials.gov

NIH grants 3598

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant512,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award352,025NIH's project files
P30CA016672Cancer Center Support Grant322,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant162,025NIH's project files
P30CA016058Cancer Center Support Grant132,025NIH's project files
R01CA164273Overcoming Resistance Mechanisms to Anaplastic Lymphoma Kinase Inhibitors102,025NIH's project files
K12CA086913Paul Calabresi Award in Clinical Oncology Research92,025NIH's project files
P30CA068485Cancer Center Support Grant82,025NIH's project files
IK6BX004209BLRD Research Career Scientist Award Application72,025NIH's project files
P30AG072975Rush Alzheimer's Disease Research Center72,025NIH's project files

Papers 5837

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826657PubTator, text miningPubMed
42798643PubTator, text miningPubMed
42780883PubTator, text miningPubMed
42780555PubTator, text miningPubMed
42778291PubTator, text miningPubMed
42774843PubTator, text miningPubMed
42771061PubTator, text miningPubMed
42768906PubTator, text miningPubMed
42760507PubTator, text miningPubMed
42757049PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license